Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
Curr Opin Pharmacol. 2023 Jun 14;71:102384. doi: 10.1016/j.coph.2023.102384. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCRs) are ligand-activated cell membrane proteins and represent the most important class of drug targets. GPCRs adopt several active conformations that stimulate different intracellular G proteins (and other transducers) and thereby modulate second messenger levels, eventually resulting in receptor-specific cell responses. It is increasingly accepted that not only the type of active signaling protein but also the duration of its stimulation and the subcellular location from where receptor...
Source: Current Opinion in Pharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Charlotte Kayser Barbora Melkes C écile Derieux Andreas Bock Source Type: research

Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research

Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research

Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research

Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Curr Opin Pharmacol. 2023 Jun 10;71:102382. doi: 10.1016/j.coph.2023.102382. Online ahead of print.ABSTRACTGonadotropin-releasing hormone (GnRH) neurons are the final output pathway for the brain control of reproduction. The activity of this neuronal population, mainly located at the preoptic area of the hypothalamus, is controlled by a plethora of metabolic signals. However, it has been documented that most of these signal impact on GnRH neurons through indirect neuronal circuits, Kiss1, proopiomelanocortin, and neuropeptide Y/agouti-related peptide neurons being some of the most prominent mediators. In this context, comp...
Source: Current Opinion in Pharmacology - June 12, 2023 Category: Drugs & Pharmacology Authors: Miguel Ruiz-Cruz Carmen Torres-Granados Manuel Tena-Sempere Juan Roa Source Type: research

Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research

Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research

Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research

Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research

Corrigendum to "Antihypertensive effect of soybean bioactive peptides: A review" [Curr Opin Pharmacol (62) (2022) 74-81]
Curr Opin Pharmacol. 2023 Jun 3;71:102383. doi: 10.1016/j.coph.2023.102383. Online ahead of print.NO ABSTRACTPMID:37276767 | DOI:10.1016/j.coph.2023.102383 (Source: Current Opinion in Pharmacology)
Source: Current Opinion in Pharmacology - June 5, 2023 Category: Drugs & Pharmacology Authors: Tingna Li Xiaorui Zhang Yuanyuan Ren Yijia Zeng Qinwan Huang Chao Wang Source Type: research