Retention and adherence: global challenges for the long-term care of adolescents and young adults living with HIV
Purpose of review
Adolescents living with HIV are the only age group with increasing HIV mortality at a time of global scale-up of access to antiretroviral therapy (ART). As a ‘treat all’ strategy is implemented worldwide, it is critically important to optimize retention and adherence for this vulnerable group.
Recent findings
Adolescents and young adults living with HIV have poorer outcomes when compared with adults at each stage of the HIV care cascade, irrespective of income setting. Rates of viral suppression are lowest for adolescents living with HIV, and adherence to ART remains an enormous challenge. High-q...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research
Mental health and substance use in HIV-infected adolescents
Purpose of review
Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These are important issues in their own right as well as having implications for antiretroviral therapy (ART) adherence and HIV management.
Recent findings
Sixteen articles, published from 1 January 2016 to 1 September 2017, were included from 13 distinct studies, mostly from the United States and Africa. Cross...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research
Cancer in adolescents and young adults living with HIV
Purpose of review
Adults living with HIV have an increased risk of malignancy yet there is little data for adolescents and young adults. We reviewed recently published cancer epidemiology, treatment, and outcome data for adolescents and young adults living with HIV (AYALHIV) aged 10 to less than 25 years between 2016 and 2017.
Recent findings
AYALHIV are at increased risk of developing cancer compared to their uninfected peers. Kaposi sarcoma and non-Hodgkin lymphoma occur most frequently with variation by geographical region. Increased cancer risk is associated with HIV-related immunosuppression and coinfection with ...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research
Noncommunicable diseases in adolescents with perinatally acquired HIV-1 infection in high-income and low-income settings
Purpose of review
Perinatally HIV-infected adolescents may be at increased risk of noninfectious comorbidities later in life. This review summarizes recent advances in the understanding of noncommunicable diseases (NCD) among HIV-infected adolescents in high-income and lower middle-income countries, and identifies key questions that remain unanswered. We review atherosclerotic vascular disease (AVD), chronic bone disease (CBD), chronic kidney disease (CKD), and chronic lung disease (CLD).
Recent findings
Persistent immune activation and inflammation underlie the pathogenesis of AVD, highlighting the importance of trea...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research
Growth and pubertal development in HIV-infected adolescents
We present an overview of recent research in the inter-related areas of growth and pubertal development among adolescents with HIV. Growth deficits early in childhood can lead to delayed puberty, with subsequent effects on pubertal growth spurts and bone health.
Recent findings
Impaired growth remains a critical concern, particularly in low-resource settings, where stunting, wasting and underweight remain pervasive. Antiretroviral treatment (ART) initiation results in improved growth, with greatest growth recovery in the first years and more improvement in weight than in height. However, even years after ART initiation,...
Source: Current Opinion in HIV and AIDS - May 1, 2018 Category: Infectious Diseases Tags: ADOLESCENTS AND HIV: Edited by Mary-Ann Davies and Elizabeth Hamlyn Source Type: research
