Current Opinion in Chemical Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats
Curr Opin Chem Biol. 2023 Jul 28;76:102374. doi: 10.1016/j.cbpa.2023.102374. Online ahead of print.ABSTRACTThe long luminescence lifetimes and sharp emission bands of luminescent lanthanide complexes have long been recognized as invaluable strengths for sensing and imaging in complex aqueous biological or environmental media. Herein we discuss the recent developments of these probes for sensing metal ions and, increasingly, anions. Underappreciated in the field, buffers and metal hydrolysis influence the response of many responsive lanthanide probes. The inherent complexities arising from these interactions are further dis...
Source: Current Opinion in Chemical Biology - July 30, 2023 Category: Biochemistry Authors: Thibaut L M Martinon Val érie C Pierre Source Type: research

Peptide-based molecules for the disruption of bacterial Hsp70 chaperones
Curr Opin Chem Biol. 2023 Jul 27;76:102373. doi: 10.1016/j.cbpa.2023.102373. Online ahead of print.ABSTRACTDnaK is a chaperone that aids in nascent protein folding and the maintenance of proteome stability across bacteria. Due to the importance of DnaK in cellular proteostasis, there have been efforts to generate molecules that modulate its function. In nature, both protein substrates and antimicrobial peptides interact with DnaK. However, many of these ligands interact with other cellular machinery as well. Recent work has sought to modify these peptide scaffolds to create DnaK-selective and species-specific probes. Other...
Source: Current Opinion in Chemical Biology - July 29, 2023 Category: Biochemistry Authors: Aweon Richards Tania J Lupoli Source Type: research

Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles
Curr Opin Chem Biol. 2023 Jul 22;76:102372. doi: 10.1016/j.cbpa.2023.102372. Online ahead of print.ABSTRACTChemical elements, especially metals, play very specific roles in the life sciences. The implementation of correlative imaging methods, of elements on the one hand and of molecules or biological structures on the other hand, is the subject of recent developments. The most commonly used spectro-imaging techniques for metals are synchrotron-induced X-ray fluorescence, mass spectrometry and fluorescence imaging of metal molecular sensors. These imaging methods can be correlated with a wide variety of other analytical tec...
Source: Current Opinion in Chemical Biology - July 24, 2023 Category: Biochemistry Authors: St éphane Roudeau Asuncion Carmona Richard Ortega Source Type: research

Recent advances towards mass spectrometry-based clinical lipidomics
The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices. The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest inno...
Source: Current Opinion in Chemical Biology - July 20, 2023 Category: Biochemistry Authors: Samira Salihovic Santosh Lamichane Tuulia Hy ötyläinen Matej Ore šič Source Type: research

The influence of alkylating agents on sulfur-sulfur bonds in per- and polysulfides
Curr Opin Chem Biol. 2023 Jul 18;76:102368. doi: 10.1016/j.cbpa.2023.102368. Online ahead of print.ABSTRACTPer- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants and humans, but their biological roles remain to be fully understood. Unfortunately, due to their reactivity, per- and polysulfides are easily altered, interconverted or lost during the processing and analysis of biological material. Thus, all current analytical methods make use of alkylating agents, to quench reactivity of hydropersulfides and hydropolysulfides and also to prevent free thiols fro...
Source: Current Opinion in Chemical Biology - July 20, 2023 Category: Biochemistry Authors: Danny Schilling Tam ás Ditrói Uladzimir Barayeu Eszter Petra Jur ányi Peter Nagy Tobias P Dick Source Type: research