Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans
Curr Opin Chem Biol. 2023 Dec 22;78:102417. doi: 10.1016/j.cbpa.2023.102417. Online ahead of print.ABSTRACTGlycosylation is one of the most common post-translational modifications of proteins, which plays essential roles in regulating the biological functions of proteins. Efficient and versatile methods for the synthesis of homogeneous and well-defined N- and O-glycans remain an urgent need for biological studies and biomedical applications. Despite their structural complexity, tremendous progress has been made in the synthesis of N- and O-glycans in recent years. This review discusses some recent advances in the enzymatic...
Source: Current Opinion in Chemical Biology - December 23, 2023 Category: Biochemistry Authors: Zhi-Fei Hu Kan Zhong Hongzhi Cao Source Type: research

Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans
Curr Opin Chem Biol. 2023 Dec 22;78:102417. doi: 10.1016/j.cbpa.2023.102417. Online ahead of print.ABSTRACTGlycosylation is one of the most common post-translational modifications of proteins, which plays essential roles in regulating the biological functions of proteins. Efficient and versatile methods for the synthesis of homogeneous and well-defined N- and O-glycans remain an urgent need for biological studies and biomedical applications. Despite their structural complexity, tremendous progress has been made in the synthesis of N- and O-glycans in recent years. This review discusses some recent advances in the enzymatic...
Source: Current Opinion in Chemical Biology - December 23, 2023 Category: Biochemistry Authors: Zhi-Fei Hu Kan Zhong Hongzhi Cao Source Type: research

Synthesis and application of bacterial exopolysaccharides
Curr Opin Chem Biol. 2023 Dec 21;78:102418. doi: 10.1016/j.cbpa.2023.102418. Online ahead of print.ABSTRACTExopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of...
Source: Current Opinion in Chemical Biology - December 22, 2023 Category: Biochemistry Authors: Gijs Ruijgrok Dung-Yeh Wu Herman S Overkleeft Jeroen D C Cod ée Source Type: research

Synthesis and application of bacterial exopolysaccharides
Curr Opin Chem Biol. 2023 Dec 21;78:102418. doi: 10.1016/j.cbpa.2023.102418. Online ahead of print.ABSTRACTExopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of...
Source: Current Opinion in Chemical Biology - December 22, 2023 Category: Biochemistry Authors: Gijs Ruijgrok Dung-Yeh Wu Herman S Overkleeft Jeroen D C Cod ée Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Curr Opin Chem Biol. 2023 Dec 11;78:102407. doi: 10.1016/j.cbpa.2023.102407. Online ahead of print.ABSTRACTThe aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteom...
Source: Current Opinion in Chemical Biology - December 12, 2023 Category: Biochemistry Authors: Cristina Balcells Yitao Xu Rub én Gil-Solsona L éa Maitre Pablo Gago-Ferrero Hector C Keun Source Type: research

Editorial overview: Glycobiology (2023)
Curr Opin Chem Biol. 2023 Dec;77:102406. doi: 10.1016/j.cbpa.2023.102406. Epub 2023 Nov 11.NO ABSTRACTPMID:37956566 | DOI:10.1016/j.cbpa.2023.102406 (Source: Current Opinion in Chemical Biology)
Source: Current Opinion in Chemical Biology - November 13, 2023 Category: Biochemistry Authors: Matthew S Macauley Source Type: research

Editorial overview: Glycobiology (2023)
Curr Opin Chem Biol. 2023 Dec;77:102406. doi: 10.1016/j.cbpa.2023.102406. Epub 2023 Nov 11.NO ABSTRACTPMID:37956566 | DOI:10.1016/j.cbpa.2023.102406 (Source: Current Opinion in Chemical Biology)
Source: Current Opinion in Chemical Biology - November 13, 2023 Category: Biochemistry Authors: Matthew S Macauley Source Type: research

Editorial overview: Glycobiology (2023)
Curr Opin Chem Biol. 2023 Dec;77:102406. doi: 10.1016/j.cbpa.2023.102406. Epub 2023 Nov 11.NO ABSTRACTPMID:37956566 | DOI:10.1016/j.cbpa.2023.102406 (Source: Current Opinion in Chemical Biology)
Source: Current Opinion in Chemical Biology - November 13, 2023 Category: Biochemistry Authors: Matthew S Macauley Source Type: research