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Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Curr Opin Chem Biol. 2023 Sep 4;77:102386. doi: 10.1016/j.cbpa.2023.102386. Online ahead of print.NO ABSTRACTPMID:37672839 | DOI:10.1016/j.cbpa.2023.102386 (Source: Current Opinion in Chemical Biology)
Source: Current Opinion in Chemical Biology - September 6, 2023 Category: Biochemistry Authors: Cong Liu Xin Zhang Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

Recent advances in Zn < sup > 2+ < /sup > imaging: From organelles to in  vivo applications
Curr Opin Chem Biol. 2023 Aug 24;76:102378. doi: 10.1016/j.cbpa.2023.102378. Online ahead of print.ABSTRACTZn2+ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn2+ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn2+. However, this task is quite challenging since Zn2+ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn2+ imaging in o...
Source: Current Opinion in Chemical Biology - August 26, 2023 Category: Biochemistry Authors: Hongbao Fang Yaheng Li Xiuzhi Yang Yuncong Chen Zijian Guo Weijiang He Source Type: research

How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research

How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research

How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research

How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research

How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research