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How nature incorporates sulfur and selenium into bioactive natural products
Curr Opin Chem Biol. 2023 Aug 18;76:102377. doi: 10.1016/j.cbpa.2023.102377. Online ahead of print.ABSTRACTLiving organisms have evolved various strategies to incorporate sulfur and selenium into bioactive natural products. These chalcogen-containing compounds serve important and diverse biological functions for their producers and many of them are essential medicines against infectious diseases and cancer. We review recent advances in the biosynthesis of some sulfur/selenium-containing natural products with a focus on the formation or cleavage of C-S/C-Se bonds. We highlight unusual enzymes that catalyze these transformat...
Source: Current Opinion in Chemical Biology - August 20, 2023 Category: Biochemistry Authors: Xiaoyan Chen Bo Li Source Type: research

A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
Curr Opin Chem Biol. 2023 Aug 10;76:102376. doi: 10.1016/j.cbpa.2023.102376. Online ahead of print.ABSTRACTCancer imaging is a rapidly evolving field due to the discovery of novel molecular targets and the availability of corresponding techniques to detect them with high precision, accuracy, and sensitivity. Nuclear medicine is the most widely used molecular imaging modality and has a growing toolkit of clinically used radiopharmaceuticals that enable whole-body tumor visualization, staging, and treatment monitoring for a variety of tumors in a non-invasive manner. The need for similar imaging capabilities in the operating...
Source: Current Opinion in Chemical Biology - August 12, 2023 Category: Biochemistry Authors: Teresa E Sullivan Servando Hernandez Vargas Sukhen C Ghosh Solmaz AghaAmiri Naruhiko Ikoma Ali Azhdarinia Source Type: research

Virus-assisted directed evolution of biomolecules
Curr Opin Chem Biol. 2023 Aug 3;76:102375. doi: 10.1016/j.cbpa.2023.102375. Online ahead of print.ABSTRACTDirected evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However, the slow pace of natural evolution does not support the demand for rapidly generating new biomolecular functions in the laboratory. Viruses offer a unique path to design fast laboratory evolution experiments, owing to their innate ability to evolve much more rapidly than most living organisms, facilitated by a smaller genome size that tolerate a high frequency of ...
Source: Current Opinion in Chemical Biology - August 5, 2023 Category: Biochemistry Authors: Delilah Jewel Quan Pham Abhishek Chatterjee Source Type: research