Gynecologic Care for Transgender Adults
AbstractPurpose of the ReviewTransgender people need both routine gynecological and reproductive health care and services specific to gender-affirming processes. However, there is little evidence to guide their routine gynecological and reproductive health care, and data suggests that 33% of transgender people avoid routine health care due to persistent discrimination and disrespect. Here we systematically approach the care of transmasculine and transfeminine people for practicing obstetrician-gynecologists (OBGYNs) with an eye towards enhancing knowledge and enhancing respectful care.Recent FindingsThough hampered by a pa...
Source: Current Obstetrics and Gynecology Reports - May 2, 2017 Category: OBGYN Source Type: research

Misoprostol in Abortion Care: Review and Update
AbstractPurpose of ReviewWe seek to update readers on misoprostol use in abortion care. We discuss literature on misoprostol use in first trimester medication abortion, second trimester induction abortion, management of early pregnancy loss, and first and second trimester surgical abortion. We review publications investigating efficacy, acceptability, and safety of misoprostol doses, routes of administration, use with mifepristone and osmotic dilators, and timing in relation to mifepristone or surgery.Recent FindingsIn 2016, the Food and Drug Administration approved updated labeling for medication abortion: mifepristone 20...
Source: Current Obstetrics and Gynecology Reports - April 29, 2017 Category: OBGYN Source Type: research

Genetic Screening and Early Recurrent Pregnancy Loss
AbstractPurpose of ReviewThe purpose of this review is to identify current data and provide a clear treatment path specifically the role of preimplantation genetic screening (PGS) for the evaluation and treatment of recurrent early pregnancy loss (RPL).Recent FindingsRecent data within the causes of RPL have established that the role of genetics, specifically chromosomal aneuploidy, is far more significant as a cause of the disorder than has been traditionally believed. Current data suggests that at least 50% of all first trimester losses are a result of such chromosomal copy number errors. Furthermore, therapeutic techniq...
Source: Current Obstetrics and Gynecology Reports - April 29, 2017 Category: OBGYN Source Type: research

Hysterectomy for the Transgender Man
AbstractPurpose of ReviewOur objective is to summarize the most recent, high-quality data regarding perioperative recommendations for hysterectomy and salpingo-oophorectomy in transgender and gender nonconforming individuals.Recent FindingsMany transgender men desire hysterectomy and salpingo-oophorectomy for gender affirmation, cancer-risk reduction, pelvic pain, or abnormal uterine bleeding. Gender-confirming hysterectomy is safe, effective, and highly beneficial for well-counseled patients. Preoperative considerations include optimizing the office environment, preoperative testing specific to patients with long-term tes...
Source: Current Obstetrics and Gynecology Reports - April 29, 2017 Category: OBGYN Source Type: research

Progestin-Only Contraception and Bone Health
AbstractPurpose of ReviewProgestin-only contraceptive methods are important and effective options for women trying to prevent unintended pregnancy. There is concern about progestin-only methods and bone health, particularly for depot medroxyprogesterone acetate (DMPA), because progestin-only methods can lower estradiol levels through ovarian suppression. This is of particular concern for adolescents building bone and perimenopausal women heading towards menopause.Recent FindingsDMPA does cause temporary bone loss, but this is reversible after discontinuation. Evidence is limited as to whether the decreased bone density and...
Source: Current Obstetrics and Gynecology Reports - April 29, 2017 Category: OBGYN Source Type: research

Unscheduled Bleeding on Hormonal Contraceptives: Pathophysiology, Evaluation, and Management Options
AbstractPurpose of ReviewUnscheduled bleeding is a common side effect of hormonal contraception and is a common reason for method discontinuation. This review summarizes the pathophysiology, evaluation, and current evidence-based management recommendations for the unscheduled bleeding that can occur with hormonal contraception use.Recent FindingsPrior to initiation of a hormonal contraceptive method, detailed structured counseling about the likelihood of unscheduled bleeding and its likely improvement with continued use is an important component of method continuation and patient satisfaction. For unscheduled bleeding that...
Source: Current Obstetrics and Gynecology Reports - April 29, 2017 Category: OBGYN Source Type: research

Intrauterine Devices and Contraceptive Implants: Overview of Options and Updates on Method Use
AbstractPurpose of ReviewIntrauterine devices (IUDs) and contraceptive implants offer safe and highly effective long-acting reversible contraception (LARC) without requiring routine effort from users. A majority of women who choose these methods report high satisfaction; 12-month continuation rates typically exceed 80%. We summarize some of the latest research and recommendations for use of currently available LARC methods to promote high-quality service delivery.Recent FindingsNew hormonal LARC methods are available, and research suggests that the duration of contraceptive protection for some existing methods extends beyo...
Source: Current Obstetrics and Gynecology Reports - April 22, 2017 Category: OBGYN Source Type: research

Vaginoplasty for the Transgender Woman
AbstractPurpose of ReviewThe purpose of this review was to describe the most common male-to-female vaginoplasty surgical techniques, and to review important perioperative considerations, outcomes, and complications associated with these surgeries.Recent FindingsVaginoplasty for the transgender woman may be performed using a variety of techniques. Most commonly, the penile inversion vaginoplasty technique is used, but in some cases, the intestinal segment vaginoplasty is indicated. Intraoperative complications of vaginoplasty surgery include bleeding and injury to the bladder, urethra, and/or rectum. Immediate postoperative...
Source: Current Obstetrics and Gynecology Reports - April 20, 2017 Category: OBGYN Source Type: research

Erratum to: What Does the Data Show for Primary Ovarian Insufficiency?
(Source: Current Obstetrics and Gynecology Reports)
Source: Current Obstetrics and Gynecology Reports - March 8, 2017 Category: OBGYN Source Type: research

Development and Initial Clinical Experience with AltaSeal ®: a Novel Hysteroscopically Placed Permanent Contraception System
AbstractPurpose of ReviewThe purpose of this paper is to review the development and clinical evaluation of AltaSeal ® which is being developed as an easy-to-use hysteroscopic sterilization implant. The implant made from 316 LVM bio-compatible stainless steel has been tested in clinical trials both for its efficacy in preventing pregnancy and its ability to occlude fallopian tubes with hydrosalpinges ahead of in vitro fertilization (IVF) therapies.Recent FindingsThe clinical data to date suggests that when placed correctly, AltaSeal ® can effectively prevent pregnancy. In an observational study of patients with hydrosalpi...
Source: Current Obstetrics and Gynecology Reports - March 5, 2017 Category: OBGYN Source Type: research

Gravity and Embryo Development
This article examines the devices used to simulate microgravity on Earth. It also explores the evidence behind microgravity ’s effects on immunomodulation, cell signaling pathways, and gene activation, as well as the impact of these changes on embryo development.SummaryAs humans look to the stars with plans for eventual colonization of space stations and other planets, understanding and overcoming the detrimental effects of microgravity on embryo development will be important in creating successful extraplanetary assisted reproductive technology (ART) programs. The necessity of this work becomes ever greater as our popul...
Source: Current Obstetrics and Gynecology Reports - March 2, 2017 Category: OBGYN Source Type: research

An Updated Review of Ectopic Pregnancies Resulting from Assisted Reproduction
AbstractPurpose of ReviewThe purpose of this study was to review the most recent data regarding clinical risk factors for ectopic pregnancy (EP) among patients pursuing assisted reproduction, and the diagnosis and management of EP in this specific population.Recent FindingsEP rates following assisted reproduction have fallen over time to 1 –2%, identical to the general population. Clinical risk factors for EP following assisted reproduction include the transfer of autologous, fresh and cleavage-stage embryos. Use of a GnRH agonist trigger alone for fresh cycles is associated with a greater risk of EP than hCG trigger. Se...
Source: Current Obstetrics and Gynecology Reports - February 26, 2017 Category: OBGYN Source Type: research

Erratum to: Addressing End-of-Life Care in Cancer Patients through “Ubuntu”: Lessons Learned from Rwanda in Global Health Perspective of Humanity
(Source: Current Obstetrics and Gynecology Reports)
Source: Current Obstetrics and Gynecology Reports - February 20, 2017 Category: OBGYN Source Type: research

Uterine Fibroids in the Setting of Infertility: When to Treat, How to Treat?
AbstractPurpose of ReviewWe aim to provide insight on the treatment of fibroids in the infertile patient. Specifically, we discuss which fibroids, based on size and location within the uterine wall, have the most impact on fertility outcomes. In addition, we demonstrate which methods are best for treatment of fibroids in the infertile patient, focusing on minimally invasive techniques.Recent FindingsCurrent research demonstrates that, in addition to submucosal fibroids, also intramural fibroids can have a negative impact on fertility via molecular and mechanical disruption of the endometrium and of normal uterine peristals...
Source: Current Obstetrics and Gynecology Reports - February 17, 2017 Category: OBGYN Source Type: research

Update on Fibroid Morcellation
AbstractPurpose of ReviewThe aim of this paper is to review the risks associated with morcellation of uterine and fibroid tissue during minimally invasive surgery, and provide updated suggestions for practice.Recent FindingsThe prevalence of occult uterine sarcoma has been estimated to be in the range of 1 case per 278 –8300, with significant variance reported. Strong predictors of occult malignancy include age, black race, and long-term tamoxifen use. Patient symptoms, lab abnormalities, imaging findings, and preoperative sampling may be useful in preoperative patient selection. Several tissue extraction techni ques hav...
Source: Current Obstetrics and Gynecology Reports - February 14, 2017 Category: OBGYN Source Type: research