Molar Pregnancy: Epidemiology, Diagnosis, Management, Surveillance
AbstractPurpose of ReviewThis review describes recommendations for the diagnosis and management of molar pregnancy, with focus on emerging evidence in recent years, particularly as it pertains to nuances of diagnosis, risk stratification, and surveillance of post-molar malignant trophoblastic disease.Recent FindingsTopics discussed include advances in histopathologic diagnosis of molar pregnancy to standardize analysis, most recent estimations of post-molar pregnancy malignancy, and updated surveillance guidelines.SummaryHydatidiform molar pregnancy, resulting from an abnormal fertilization event, is the proliferation of a...
Source: Current Obstetrics and Gynecology Reports - February 19, 2022 Category: OBGYN Source Type: research

Alleviating Pain with IUD Placement: Recent Studies and Clinical Insight
AbstractPurpose of ReviewThe pain associated with intrauterine device placement (IUD) may decrease uptake of this highly effective form of contraception. The purpose of this review is to present recently studied methods and techniques employed by clinicians to reduce pain with IUD placement.Recent FindingsParacervical and intracervical lidocaine blocks are effective options for pain control during IUD placement. Lidocaine blocks are particularly effective in nulliparous patients during IUD placement. Topical or vaginal lidocaine are not effective in decreasing pain with IUD placement.SummaryBased on the existing published ...
Source: Current Obstetrics and Gynecology Reports - February 12, 2022 Category: OBGYN Source Type: research

Classifications of Adenomyosis and Correlation of Phenotypes in Imaging and Histopathology to Clinical Outcomes: a Review
AbstractPurpose of ReviewTo provide an update on published classification and reporting systems for adenomyosis. There is an urgent need to standardize reporting of various phenotypes of adenomyosis into a validated and globally recognized system. This can be used to examine the nature and severity of adenomyosis symptoms and inform the design, evaluation, and implementation of appropriate treatment options.Recent FindingsIn recent years, several new proposals for adenomyosis classification have emerged. Most are MRI-based and include features such as uterine size, junctional zone thickness, size and location of the lesion...
Source: Current Obstetrics and Gynecology Reports - February 7, 2022 Category: OBGYN Source Type: research

HPV and Oral Cavity Diseases
AsbtractPurpose of ReviewThe aim of this paper is to describe clinical manifestations of oral infection by human papillomavirus (HPV), as every year higher numbers of patients are admitted to hospital with intraoral lesion.Recent FindingsIn recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. As the interaction between the head& neck region and HPV is better understood, prognosis of the diseases especially for malignant lesions, are get better understood and more ...
Source: Current Obstetrics and Gynecology Reports - January 20, 2022 Category: OBGYN Source Type: research

New Contraception Update — Annovera, Phexxi, Slynd, and Twirla
AbstractPurpose of ReviewIn this review, we discuss the efficacy, safety, and benefits of four new contraceptive products available in the USA, specifically Annovera, Phexxi, Slynd, and Twirla.Recent FindingsAnnovera is a vaginal ring releasing ethinyl estradiol and segesterone acetate that can be used for up to one year (13 cycles), offering patients an effective, user-controlled option that may improve contraceptive access for those in low-resource settings or those with barriers to retrieving monthly prescriptions; however, given limited efficacy and safety data in people with body mass index (BMI)  >  29 kg/m2,...
Source: Current Obstetrics and Gynecology Reports - January 6, 2022 Category: OBGYN Source Type: research

Preimplantation Genetic Testing for Aneuploidy: Has the Controversy Settled? A Review
AbstractPurpose of ReviewThis review is aimed at providing an overview of the development of, and advances in preimplantation genetic testing for aneuploidy (PGT-A) in the last decade. It will summarize advances in the field to date, ongoing controversies, and explore ideas for future directions.Recent FindingsRecent findings in the field of PGT-A include the publication of the STAR trial in 2019. This large RCT failed to find a benefit for PGT-A in women aged 25 –40. As a result of increasing use of PGT-A with comprehensive genomic sequencing, the number of mosaic embryos identified has increased, with an ongoing debate...
Source: Current Obstetrics and Gynecology Reports - January 4, 2022 Category: OBGYN Source Type: research

Sexually Transmitted Infections in Pregnancy, Screening and Treatment
AbstractPurpose of ReviewSexually transmitted diseases (STD) often complicate the pregnancy when conception occurs through unprotected intercourse. The importance and management of STDs in terms of pregnancy are examined in this review.Recent FindingsDuring pregnancy, STDs must be investigated and treated aggressively because of the effects on both mother and fetus. With screening tests, an STD such as gonorrhea, chlamydia or syphilis can be determined in approximately 10% of all pregnant patients. In addition, when the spouse is not monogamous, a new STD can be contracted during pregnancy, and any STD in pregnancy has sig...
Source: Current Obstetrics and Gynecology Reports - November 25, 2021 Category: OBGYN Source Type: research

Association of Human Papillomavirus and Chlamydia trachomatis Coinfection with Cervical Intraepithelial Lesions and Cervical Cancer
AbstractPurpose of ReviewThe aim of this review is to evaluate the association of human papillomavirus andChlamydia trachomatis coinfection with cervical intraepithelial lesions and cervical cancer.Recent FindingsSexually transmitted infections are admitted as one of the most common public health problems globally. Human papillomavirus (HPV) is the most frequent viral andChlamydia trachomatis is the most frequent bacterial sexually transmitted infections. Infection with HPV is considered as necessary but not sufficient for cervical carcinogenesis. HPV infections are generally transient and asymptomatic, but persistence of ...
Source: Current Obstetrics and Gynecology Reports - November 25, 2021 Category: OBGYN Source Type: research

Embryos with a Mosaic Result: the Known and Unknown Reproductive Potential
AbstractPurpose of ReviewInterest regarding the transfer of embryos with a mosaic result has increased in recent years as outcome data continues to aggregate since the first published report of livebirths after the transfer of embryos with a mosaic result in 2015. The purpose of this review is to distill the available published literature on the transfer of embryos with a mosaic result in order to empower clinicians to understand and counsel patients on this topic.Recent FindingsEmbryos with a mosaic result have clear reproductive potential, though the live birth rate from these embryos is usually reported to be lower than...
Source: Current Obstetrics and Gynecology Reports - November 15, 2021 Category: OBGYN Source Type: research

Review of Infertility Diagnosis and Evaluation
AbstractPurpose of ReviewThe purpose of this review is to update readers on the basic guidelines for the diagnosis and evaluation of a new female or male infertility patient within the scope of Obstetrics and Gynecology.Recent FindingsDespite the longevity of the knowledge of infertility, it is still antiquated by the definition of the term; thus, the subsequent barriers to care for same-sex couples and single women who seek infertility treatment are unable to receive coverage due to the inability to meet certain criteria for diagnosis.SummaryThe issue of infertility is increasingly common as women and men delay family bui...
Source: Current Obstetrics and Gynecology Reports - November 6, 2021 Category: OBGYN Source Type: research

Thyroid Disease, Pregnancy, and Selenium Supplementation
This study has the purpose of investigating the possible therapeutic use of selenium supplementation in pregnant women with thyroid autoimmune disease, with a focus on the maternal and fetal outcomes. A review of the literature on Pubmed has been conducted, in order to have a general picture of the current knowledge about pregnancy and autoimmune thyroid disease: outcomes and therapy.Recent FindingsThe present literature agrees on the several positive roles of selenium in women ’s reproductive life. It reduces the oxidative stress on the placenta and facilitates fertility and embryo development; it may reduce the onset o...
Source: Current Obstetrics and Gynecology Reports - November 5, 2021 Category: OBGYN Source Type: research

Anti-M üllerian Hormone: Current Understanding and Clinical Use
AbstractPurpose of ReviewAnti-M üllerian hormone (AMH) is secreted by ovarian granulosa cells and has become a surrogate marker for ovarian reserve. We review anticipated AMH levels throughout the reproductive lifespan and how AMH levels can be used in assisted reproductive technology.Recent FindingsWhile AMH is a surrogate marker for ovarian reserve, values do not predict fertility. Patients with low versus normal AMH have similar fertility. AMH levels are helpful in guiding treatment for infertility, including medication dosing for IVF and anticipated cycle outcomes. AMH levels are positively correlated with ovarian res...
Source: Current Obstetrics and Gynecology Reports - October 20, 2021 Category: OBGYN Source Type: research

Management of Ovarian Endometrioma in Asymptomatic Reproductive Age Women
AbstractPurpose of ReviewIn asymptomatic women of reproductive age, the presence of an ovarian endometrioma raises a significant management dilemma.Recent FindingsSurgical management may afford more definitive treatment as well as an opportunity to treat concurrent extra-ovarian endometriotic disease. However, the associated impact on ovarian reserve with ovarian surgery may be an example of the cure being worse than the disease. Several conservative treatments have been studied, all with varying clinical benefits. Expectant management, while a conservative option, may complicate access to growing ovarian follicles and rai...
Source: Current Obstetrics and Gynecology Reports - October 14, 2021 Category: OBGYN Source Type: research

Recent Advances and Current Perspectives on Endometrial Receptivity
AbstractPurpose of ReviewThe purpose of this review is to update readers on our current understanding of endometrial receptivity and to review the literature regarding endometrial assessment and pathologic states which may influence receptivity.Recent FindingsTopics discussed include molecular mechanisms implicated in endometrial receptivity on the basis of which three commercially available yet controversial tests have been developed (Endometrial Function Test, Endometrial Receptivity Assay, and ReceptivaDx), as well as current evidence surrounding how common gynecologic conditions such as polyps, fibroids, adenomyosis, a...
Source: Current Obstetrics and Gynecology Reports - October 6, 2021 Category: OBGYN Source Type: research

Oncofertility: a Review
AbstractPurpose of ReviewThe purpose of this review is to describe the latest methods of fertility preservation for female cancer patients, as well as the associated psychological benefits, pregnancy outcomes, and oncological outcomes of these techniques.Recent FindingsUsing random-start controlled ovarian stimulation for embryo and oocyte cryopreservation provides adequate oocyte yield and minimizes delay to starting cancer treatment. Protocols including estrogen-lowering medications should be used in women with hormone-sensitive cancers. Newer methods including ovarian tissue cryopreservation and ovarian transposition ha...
Source: Current Obstetrics and Gynecology Reports - October 1, 2021 Category: OBGYN Source Type: research