Genome-wide association studies of REST gene associated neurological diseases/traits with related single nucleotide polymorphisms
CONCLUSION: This work offers fresh insights into identifying risk loci of neurological disorders caused by REST.PMID:37518996 | DOI:10.2174/1567202620666230727153306 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 31, 2023 Category: Neurology Authors: Sagor Kumar Roy Jingjing Wang Seidu A Richard Yuming Xu Source Type: research
The Metabolic Basis for Nervous System Dysfunction in Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease
Curr Neurovasc Res. 2023 Jul 21. doi: 10.2174/1567202620666230721122957. Online ahead of print.ABSTRACTDisorders of metabolism affect multiple systems throughout the body but may have the greatest impact on both central and peripheral nervous systems. Currently available treatments and behavior changes for disorders that include diabetes mellitus (DM) and nervous system diseases are limited and cannot reverse the disease burden. Greater access to healthcare and a longer lifespan have led to an increased prevalence of metabolic and neurodegenerative disorders. In light of these challenges, innovative studies into the underl...
Source: Current Neurovascular Research - July 25, 2023 Category: Neurology Authors: Kenneth Maiese Source Type: research
The positional relationship between lacunae and white matter hyperintensity in patients with cerebral small vessel disease
CONCLUSION: High fasting blood glucose can be considered a risk factor for lacunae formation in patients with WMH. The more severe the PWMH and the higher the nocturnal heart rate, the more likely the lacunae, as well as PWMH, overlap completely. Ipsilateral arteriosclerosis and stenosis are independent risk factors for no contact between lacunae and PWMH.PMID:37488758 | DOI:10.2174/1567202620666230721124707 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 25, 2023 Category: Neurology Authors: Lu An Wenxin Yuan Yunchao Wang Shanshan Li Ce Zong Yuan Gao Yusheng Li Limei Wang Ya Peng Li Yan Ji Yuming Xu Source Type: research
The Association of the Spatial Location of Contrast Extravasation with Symptomatic Intracranial Hemorrhage after Endovascular Therapy in Acute Ischemic Stroke Patients
Conclusion The spatial location of CE on NCCT immediately after EVT was an independent and strong risk factor for sICH in acute ischemic stroke patients.PMID:37488759 | DOI:10.2174/1567202620666230721101413 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 25, 2023 Category: Neurology Authors: Chen Gong You Wang Jinxian Yuan Jie Zhang Shuyu Jiang Tao Xu Yangmei Chen Source Type: research
Major Targets involved in Clinical Management of Migraine
CONCLUSION: Migraine biomarkers such as CGRP, PACAP, NLRP3, Nitric oxide synthase, MMP9, and Serotonin could be targets for developing drugs. Present marketed medications temporarily reduce symptoms and pain and have serious cardiovascular side effects. It is suggested that herbal treatment may help prevent migraine attacks without adverse effects. Natural biomolecules that may give better treatment than the present marketed medication and full fledge research should be carried out with natural biomarkers by the Network Pharmacological approach.PMID:37488760 | DOI:10.2174/1567202620666230721111144 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 25, 2023 Category: Neurology Authors: Rapuru Rushendran Vellapandian Chitra Kaliappan Ilango Source Type: research
