Stabilizing Scaffold for Short Peptides Based on Knottins
CONCLUSION: Arachnid toxins with an inhibitory cystine knot can be considered as a scaffold for increasing the stability of therapeutic peptides.PMID:38357956 | DOI:10.2174/0115680096285288240118090050 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 15, 2024 Category: Cancer & Oncology Authors: Evgenii Beloborodov Elena Iurova Dmitrii Sugak Eugenia Rastorgueva Evgeniya Pogodina Aleksandr Fomin Denis Viktorov Sergei Slesarev Yury Saenko Source Type: research
H3K27ac-activated LncRNA NUTM2A-AS1 Facilitates the Progression of Colorectal Cancer Cells via MicroRNA-126-5p/FAM3C Axis
CONCLUSION: Our research proposed NUTM2A-AS1 as an oncogenic lncRNA that facilitates CRC malignancy by upregulating FAM3C expression, which might provide new insight and a promising therapeutic target for the diagnosis and treatment of CRC.PMID:38347779 | DOI:10.2174/0115680096277956240119065938 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 13, 2024 Category: Cancer & Oncology Authors: Haiguan Lin Shidong Hu Yuxuan Li Songyan Li Da Teng Yan Yang Boyan Liu Xiaohui Du Source Type: research
The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer
Curr Cancer Drug Targets. 2024 Feb 12. doi: 10.2174/0115680096281059240103154836. Online ahead of print.ABSTRACTObesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose tissue dysfunction, including insulin resistance, adipose tissue inflammation, adipocytokines secretion, and metabolic altera...
Source: Current Cancer Drug Targets - February 13, 2024 Category: Cancer & Oncology Authors: Rozita Khodashahi Fatemeh Beiraghdar Gorgon A Ferns Kiayash Ashrafzadeh Mohsen Aliakbarian Mohammad-Hassan Arjmand Source Type: research
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, Thereby Promoting Angiogenesis in Hepatocellular Carcinoma
CONCLUSION: MAZ potentiated the upregulated NEIL3-mediated glycolysis pathway and HCC angiogenesis. This study provided a rationale for the MAZ/NEIL3/glycolysis pathway as a possible option for anti-angiogenesis therapy in HCC.PMID:38347781 | DOI:10.2174/0115680096265896231226062212 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 13, 2024 Category: Cancer & Oncology Authors: Fabiao Zhang Binfeng Wang Wenlong Zhang Yongfu Xu Caiming Zhang Xiangyang Xue Source Type: research
Hybrid Nanoparticle for Co-delivering Paclitaxel and Dihydroartemisinin to Exhibit Synergic Anticancer Therapeutics
CONCLUSION: Dual-drug-loaded hybrid PLGA-lecithin NP is a potential system to minimize severe side effects while enhancing antitumor efficacy, in which lyophilization is a key process to increase stability.</p>.PMID:38321897 | DOI:10.2174/0115680096283208231229103822 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 7, 2024 Category: Cancer & Oncology Authors: Bao Ngoc Tran Thu Thi Kim Ninh Thao Thi Do Phuong Thi Do Chien Ngoc Nguyen Source Type: research
Dauricine Inhibits Non-small Cell Lung Cancer Development by Regulating PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2 Pathways in a FLT4-dependent Manner
CONCLUSION: Dauricine may be a promising FLT4 inhibitor for the treatment of NSCLC.PMID:38321898 | DOI:10.2174/0115680096282997240101192452 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 7, 2024 Category: Cancer & Oncology Authors: Jinna Liang Panpan Lei Xinyue Su Jiapan Gao Bingxi Ren Yuxiu Zhang Xiaoyu Ma Weina Ma Source Type: research
Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers
Curr Cancer Drug Targets. 2024 Feb 2. doi: 10.2174/0115680096283149240109094710. Online ahead of print.ABSTRACTMost cancer deaths are related to gastrointestinal (GI) cancers. Several environmental and genetic factors are effective in the occurrence of GI cancers, such as esophageal, stomach, colorectal, liver, and pancreatic cancers. In addition to risk factors related to lifestyle, reactive oxygen species (ROS) also play a role in GI cancers, and an increase in the amount of free radicals can lead to oxidative stress and increase the probability of malignancies. NQO1 is part of the body's antioxidant defense system that ...
Source: Current Cancer Drug Targets - February 6, 2024 Category: Cancer & Oncology Authors: Fereshte Ghorbani Afrooz Mazidimoradi Arezou Biyabani Leila Allaqoli Hamid Salehiniya Source Type: research
Research Progress of PD 1/PD L1 Inhibitors in the Treatment of Urological Tumors
In conclusion, PD-1/PD-L1 signaling pathway blockers have important research advances for the treatment of urologic tumors. Their emergence brings new hope for patients who have poor outcomes with traditional drug therapy and provides new options for immunotherapy of urologic tumors. The purpose of this article is to review the research progress of PD-1 and PD-L1 signaling pathway blockers in urologic tumors in recent years.PMID:38318829 | DOI:10.2174/0115680096278251240108152600 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 6, 2024 Category: Cancer & Oncology Authors: Lv Han Yang Meng Zhu Jianguo Source Type: research
Effect of Neoadjuvant Immunotherapy Combined with Chemotherapy on Pulmonary Function and Postoperative Pulmonary Complications in Esophageal Cancer: A Retrospective Study
CONCLUSION: NICT may improve pulmonary ventilation function but also lead to a decrease in DLCO and DLCO% pred in EC patients. Nevertheless, the decreased DLCO after NICT did not increase the risk of postoperative pulmonary complications.PMID:38310460 | DOI:10.2174/0115680096280761231229055929 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Yongyin Gao Hongdian Zhang Yanli Qiu Xueyan Bian Xue Wang Yue Li Source Type: research
Neuroinflammation in Glioblastoma: The Role of the Microenvironment in Tumour Progression
Curr Cancer Drug Targets. 2024 Jan 17. doi: 10.2174/0115680096265849231031101449. Online ahead of print.ABSTRACTGlioblastoma (GBM) stands as the most aggressive and lethal among the main types of primary brain tumors. It exhibits malignant growth, infiltrating the brain tissue, and displaying resistance toward treatment. GBM is a complex disease characterized by high degrees of heterogeneity. During tumour growth, microglia and astrocytes, among other cells, infiltrate the tumour microenvironment and contribute extensively to gliomagenesis. Tumour-associated macrophages (TAMs), either of peripheral origin or representing b...
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Ana Helena Larangeira N óbrega Rafael Sampaio Pimentel Ana Paula Prado Jenifer Garcia Rudimar Luiz Frozza Andressa Bernardi Source Type: research
IR-780 Dye-based Targeting of Cancer-associated Fibroblasts Improves Cancer Immunotherapy by Increasing Intra-tumoral T Lymphocytes Infiltration
CONCLUSION: This work provides a unique strategy for the inhibition of ECM protein deposition in the tumor microenvironment by targeted regulating of CAFs, which destroys the T cell barrier and further promotes tumor response to PD-L1 monoclonal antibody. IR-780 has been proposed as a potential therapeutic small-molecule adjuvant to promote the effect of immunotherapy.PMID:38310462 | DOI:10.2174/0115680096261142231018104854 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Wei Yang Zelin Chen Langfan Qu Can Zhang Hongdan Chen Jiancheng Zheng Wanchao Chen Xu Tan Chunmeng Shi Source Type: research
Development of Chromatin Regulator-related Molecular Subtypes and a Signature to Predict Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma
CONCLUSIONS: We identified molecular subtypes and established a novel predictive signature based on CRRGs. This effective CRRS system can possibly provide a novel research direction for exploring the correlation between CRs and HNSCC and requires further experimental validation.PMID:38310463 | DOI:10.2174/0115680096274798231121053634 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Juntao Huang Ziqian Xu ZhenZhen Wang Chongchang Zhou Yi Shen Source Type: research
Brucine Inhibits Proliferation of Pancreatic Ductal Adenocarcinoma through PI3K/AKT Pathway-induced Mitochondrial Apoptosis
CONCLUSION: Overall, these findings suggest that brucine has therapeutic potential as a remedy option for PDAC.PMID:38310464 | DOI:10.2174/0115680096274284231116104554 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: You Wu Feng Zhang Panling Xu Ping Li Source Type: research
The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer
CONCLUSION: The results of the current study suggest that MSCs loaded with oncolytic CVA21 therapy for the CRC mouse model may have some potential advantages. On the other hand, the results of the study showed that, in addition to activating the acquired immune system, the use of MSCs loaded with oncolytic CVA21 also stimulates the innate immune system by increasing levels of nitric oxide.PMID:38310465 | DOI:10.2174/0115680096273465231201115839 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Reza Karbalaee Saber Mehdizadeh Hadi Esmaeili Gouvarchin Ghaleh Morteza Izadi Bahman Jalali Kondori Ruhollah Dorostkar Seyed Morteza Hosseini Source Type: research
Cuproptosis Related Gene DLD Associated with Poor Prognosis and Malignant Biological Characteristics in Lung Adenocarcinoma
CONCLUSION: Overall, this prognostic CRG signature may play a pivotal role in LUAD outcome, while oncogene DLD may be a future therapeutic candidate for LUAD.PMID:38310466 | DOI:10.2174/0115680096271679231213060750 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 4, 2024 Category: Cancer & Oncology Authors: Xinyang Li Junshuai Rui Zihan Yang Feng Shang-Guan Haolin Shi Dengkui Wang Jiachun Sun Source Type: research
