Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Regulating Tumorigenicity and Cancer Metastasis through TRKA Signaling
Curr Cancer Drug Targets. 2023 Sep 4. doi: 10.2174/1568009623666230904150957. Online ahead of print.ABSTRACTTropomyosin receptor kinase (TRK) A, TRKA, is a specific binding receptor of nerve growth factor (NGF), which plays an essential role in the occurrence and progression of human cancers. TRKA overexpression has been proven to be a powerful carcinogenic driver and has been verified in many tumors. The TRKA receptor kinase domain is over-activated in an NGF-dependent manner, accompanied by activation of downstream signal pathways, such as RAS-MAPK, PI3K-AKT, JAK2-STAT3 pathway, PLC γ pathway, and Hippo pathway, which p...
Source: Current Cancer Drug Targets - September 6, 2023 Category: Cancer & Oncology Authors: Yichao Fan Boya Zhang Xinhui Du Bangmin Wang Qiang Yan Liangyu Guo Weitao Yao Source Type: research
