Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096280750240123054936. Online ahead of print.ABSTRACTTriple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, is characterized by the non-appearance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Clinically, TNBC is marked by its low survival rate, poor therapeutic outcomes, high aggressiveness, and lack of targeted therapies. Over the past few decades, many clinical trials have been ongoing for targeted therapies in TNBC. Although some classes, such as Poly (ADP Ribose) Polymerase...
Source: Current Cancer Drug Targets - February 22, 2024 Category: Cancer & Oncology Authors: Magham Sai Varshini Praveen Thaggikuppe Krishnamurthy Ramakamma Aishwarya Reddy Ashish Wadhwani V M Chandrashekar Source Type: research
Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096280750240123054936. Online ahead of print.ABSTRACTTriple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, is characterized by the non-appearance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Clinically, TNBC is marked by its low survival rate, poor therapeutic outcomes, high aggressiveness, and lack of targeted therapies. Over the past few decades, many clinical trials have been ongoing for targeted therapies in TNBC. Although some classes, such as Poly (ADP Ribose) Polymerase...
Source: Current Cancer Drug Targets - February 22, 2024 Category: Cancer & Oncology Authors: Magham Sai Varshini Praveen Thaggikuppe Krishnamurthy Ramakamma Aishwarya Reddy Ashish Wadhwani V M Chandrashekar Source Type: research
Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096280750240123054936. Online ahead of print.ABSTRACTTriple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, is characterized by the non-appearance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Clinically, TNBC is marked by its low survival rate, poor therapeutic outcomes, high aggressiveness, and lack of targeted therapies. Over the past few decades, many clinical trials have been ongoing for targeted therapies in TNBC. Although some classes, such as Poly (ADP Ribose) Polymerase...
Source: Current Cancer Drug Targets - February 22, 2024 Category: Cancer & Oncology Authors: Magham Sai Varshini Praveen Thaggikuppe Krishnamurthy Ramakamma Aishwarya Reddy Ashish Wadhwani V M Chandrashekar Source Type: research
Construction of an Oxidative Stress Risk Model to Analyze the Correlation Between Liver Cancer and Tumor Immunity
CONCLUSION: The combined assessment of EZH2, ANKZF1, G6PD, and HMOX1 gene expression can serve as a model to evaluate the risk of oxidative stress in HCC. Furthermore, there is a notable correlation between the expression of these risk model genes and tumor immunity.PMID:38375834 | DOI:10.2174/0115680096284532231220061048 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 20, 2024 Category: Cancer & Oncology Authors: Ying Liu Yufeng Li Li Chen Weina Zha Jing Zhang Kun Wang Chunhai Hao Jianhe Gan Source Type: research
Construction of an Oxidative Stress Risk Model to Analyze the Correlation Between Liver Cancer and Tumor Immunity
CONCLUSION: The combined assessment of EZH2, ANKZF1, G6PD, and HMOX1 gene expression can serve as a model to evaluate the risk of oxidative stress in HCC. Furthermore, there is a notable correlation between the expression of these risk model genes and tumor immunity.PMID:38375834 | DOI:10.2174/0115680096284532231220061048 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 20, 2024 Category: Cancer & Oncology Authors: Ying Liu Yufeng Li Li Chen Weina Zha Jing Zhang Kun Wang Chunhai Hao Jianhe Gan Source Type: research
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer
Curr Cancer Drug Targets. 2024 Feb 15. doi: 10.2174/0115680096277328240110062433. Online ahead of print.ABSTRACTNADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress response of the body. NADPH 9 oxidase 2 (NOX2) is the first and most representative member of the NADPH oxidase family, and its effects on the development of tumor cells are gaining more and more attention. Our previous study suggested that NCF4 polymorphism in p40phox, a key subunit of NOX2, affected the outcome of diffuse large B-cell lymphoma patients treated wi...
Source: Current Cancer Drug Targets - February 16, 2024 Category: Cancer & Oncology Authors: Shiqi Dong Chao Chen Chang Di Shufan Wang Quan Dong Wenxin Lin Duo Liu Source Type: research
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer
Curr Cancer Drug Targets. 2024 Feb 15. doi: 10.2174/0115680096277328240110062433. Online ahead of print.ABSTRACTNADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress response of the body. NADPH 9 oxidase 2 (NOX2) is the first and most representative member of the NADPH oxidase family, and its effects on the development of tumor cells are gaining more and more attention. Our previous study suggested that NCF4 polymorphism in p40phox, a key subunit of NOX2, affected the outcome of diffuse large B-cell lymphoma patients treated wi...
Source: Current Cancer Drug Targets - February 16, 2024 Category: Cancer & Oncology Authors: Shiqi Dong Chao Chen Chang Di Shufan Wang Quan Dong Wenxin Lin Duo Liu Source Type: research
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer
Curr Cancer Drug Targets. 2024 Feb 15. doi: 10.2174/0115680096277328240110062433. Online ahead of print.ABSTRACTNADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress response of the body. NADPH 9 oxidase 2 (NOX2) is the first and most representative member of the NADPH oxidase family, and its effects on the development of tumor cells are gaining more and more attention. Our previous study suggested that NCF4 polymorphism in p40phox, a key subunit of NOX2, affected the outcome of diffuse large B-cell lymphoma patients treated wi...
Source: Current Cancer Drug Targets - February 16, 2024 Category: Cancer & Oncology Authors: Shiqi Dong Chao Chen Chang Di Shufan Wang Quan Dong Wenxin Lin Duo Liu Source Type: research
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer
Curr Cancer Drug Targets. 2024 Feb 15. doi: 10.2174/0115680096277328240110062433. Online ahead of print.ABSTRACTNADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress response of the body. NADPH 9 oxidase 2 (NOX2) is the first and most representative member of the NADPH oxidase family, and its effects on the development of tumor cells are gaining more and more attention. Our previous study suggested that NCF4 polymorphism in p40phox, a key subunit of NOX2, affected the outcome of diffuse large B-cell lymphoma patients treated wi...
Source: Current Cancer Drug Targets - February 16, 2024 Category: Cancer & Oncology Authors: Shiqi Dong Chao Chen Chang Di Shufan Wang Quan Dong Wenxin Lin Duo Liu Source Type: research
Effects of HSV-G47 Δ Oncolytic Virus on Telomerase and Telomere Length Alterations in Glioblastoma Multiforme Cancer Stem Cells Under Hypoxia and Normoxia Conditions
CONCLUSION: In the glioblastoma treatment strategy, telomerase and telomere complex could be potential targets for HSV-G47Δ in both microenvironments.PMID:38357955 | DOI:10.2174/0115680096274769240115165344 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 15, 2024 Category: Cancer & Oncology Authors: Reza Vazifehmand Dhuha Saeed Ali Foroozandeh Monem Homaie Fateme Molaei Jalalvand Zulkefley Othman Chau Deming Johnson Stanslas Zamberi Sekawi Source Type: research
Stabilizing Scaffold for Short Peptides Based on Knottins
CONCLUSION: Arachnid toxins with an inhibitory cystine knot can be considered as a scaffold for increasing the stability of therapeutic peptides.PMID:38357956 | DOI:10.2174/0115680096285288240118090050 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 15, 2024 Category: Cancer & Oncology Authors: Evgenii Beloborodov Elena Iurova Dmitrii Sugak Eugenia Rastorgueva Evgeniya Pogodina Aleksandr Fomin Denis Viktorov Sergei Slesarev Yury Saenko Source Type: research
Effects of HSV-G47 Δ Oncolytic Virus on Telomerase and Telomere Length Alterations in Glioblastoma Multiforme Cancer Stem Cells Under Hypoxia and Normoxia Conditions
CONCLUSION: In the glioblastoma treatment strategy, telomerase and telomere complex could be potential targets for HSV-G47Δ in both microenvironments.PMID:38357955 | DOI:10.2174/0115680096274769240115165344 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 15, 2024 Category: Cancer & Oncology Authors: Reza Vazifehmand Dhuha Saeed Ali Foroozandeh Monem Homaie Fateme Molaei Jalalvand Zulkefley Othman Chau Deming Johnson Stanslas Zamberi Sekawi Source Type: research
Stabilizing Scaffold for Short Peptides Based on Knottins
CONCLUSION: Arachnid toxins with an inhibitory cystine knot can be considered as a scaffold for increasing the stability of therapeutic peptides.PMID:38357956 | DOI:10.2174/0115680096285288240118090050 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 15, 2024 Category: Cancer & Oncology Authors: Evgenii Beloborodov Elena Iurova Dmitrii Sugak Eugenia Rastorgueva Evgeniya Pogodina Aleksandr Fomin Denis Viktorov Sergei Slesarev Yury Saenko Source Type: research
H3K27ac-activated LncRNA NUTM2A-AS1 Facilitates the Progression of Colorectal Cancer Cells via MicroRNA-126-5p/FAM3C Axis
CONCLUSION: Our research proposed NUTM2A-AS1 as an oncogenic lncRNA that facilitates CRC malignancy by upregulating FAM3C expression, which might provide new insight and a promising therapeutic target for the diagnosis and treatment of CRC.PMID:38347779 | DOI:10.2174/0115680096277956240119065938 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 13, 2024 Category: Cancer & Oncology Authors: Haiguan Lin Shidong Hu Yuxuan Li Songyan Li Da Teng Yan Yang Boyan Liu Xiaohui Du Source Type: research
The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer
Curr Cancer Drug Targets. 2024 Feb 12. doi: 10.2174/0115680096281059240103154836. Online ahead of print.ABSTRACTObesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose tissue dysfunction, including insulin resistance, adipose tissue inflammation, adipocytokines secretion, and metabolic altera...
Source: Current Cancer Drug Targets - February 13, 2024 Category: Cancer & Oncology Authors: Rozita Khodashahi Fatemeh Beiraghdar Gorgon A Ferns Kiayash Ashrafzadeh Mohsen Aliakbarian Mohammad-Hassan Arjmand Source Type: research
