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Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

Inhibition of DYRK1A attenuates vascular remodeling in pulmonary arterial hypertension via suppressing STAT3/Pim-1/NFAT pathway
Clin Exp Hypertens. 2024 Dec 31;46(1):2297642. doi: 10.1080/10641963.2023.2297642. Epub 2023 Dec 26.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling caused by the excessive proliferation and survival of pulmonary artery smooth muscle cells (PASMCs). Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in the regulation of multiple biological functions, including cell proliferation and survival. However, the role and underlying mechanisms of DYRK1A in PAH pathogenesis remain unclear. We found that DYRK1A was upregulated in PASMCs in response...
Source: Clinical and Experimental Hypertension - December 26, 2023 Category: Cardiology Authors: Cong Lan Guangyao Fang Chenming Qiu Xiuchuan Li Fengyuan Yang Yongjian Yang Source Type: research

The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension
Clin Exp Hypertens. 2023 Dec 31;45(1):2284658. doi: 10.1080/10641963.2023.2284658. Epub 2023 Nov 27.ABSTRACTLong non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate ...
Source: Clinical and Experimental Hypertension - November 27, 2023 Category: Cardiology Authors: Jiangyong Yang Guojun Jiang Ling Huang Zhongyi Liu Rengui Jiang Gang Cao Jun Cao Hengqing Zhu Lemei Chen Xiaoming Chen Fang Pei Source Type: research

The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension
Clin Exp Hypertens. 2023 Dec 31;45(1):2284658. doi: 10.1080/10641963.2023.2284658. Epub 2023 Nov 27.ABSTRACTLong non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate ...
Source: Clinical and Experimental Hypertension - November 27, 2023 Category: Cardiology Authors: Jiangyong Yang Guojun Jiang Ling Huang Zhongyi Liu Rengui Jiang Gang Cao Jun Cao Hengqing Zhu Lemei Chen Xiaoming Chen Fang Pei Source Type: research

The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension
Clin Exp Hypertens. 2023 Dec 31;45(1):2284658. doi: 10.1080/10641963.2023.2284658. Epub 2023 Nov 27.ABSTRACTLong non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate ...
Source: Clinical and Experimental Hypertension - November 27, 2023 Category: Cardiology Authors: Jiangyong Yang Guojun Jiang Ling Huang Zhongyi Liu Rengui Jiang Gang Cao Jun Cao Hengqing Zhu Lemei Chen Xiaoming Chen Fang Pei Source Type: research

The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension
Clin Exp Hypertens. 2023 Dec 31;45(1):2284658. doi: 10.1080/10641963.2023.2284658. Epub 2023 Nov 27.ABSTRACTLong non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate ...
Source: Clinical and Experimental Hypertension - November 27, 2023 Category: Cardiology Authors: Jiangyong Yang Guojun Jiang Ling Huang Zhongyi Liu Rengui Jiang Gang Cao Jun Cao Hengqing Zhu Lemei Chen Xiaoming Chen Fang Pei Source Type: research