Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na < sup > + < /sup > excretion and insulin resistance
CONCLUSION: Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function.PMID:37943619 | DOI:10.1080/10641963.2023.2276029 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 9, 2023 Category: Cardiology Authors: Xiaoxin Zhou Longlong Zhang Xiaoqian Lin Xi Chen Hong Liu Xiaoli Yuan Qiuxia Zhao Weiwei Wang Xun Lei Pedro A Jose Chunyan Deng Jian Yang Source Type: research

Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na < sup > + < /sup > excretion and insulin resistance
CONCLUSION: Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function.PMID:37943619 | DOI:10.1080/10641963.2023.2276029 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 9, 2023 Category: Cardiology Authors: Xiaoxin Zhou Longlong Zhang Xiaoqian Lin Xi Chen Hong Liu Xiaoli Yuan Qiuxia Zhao Weiwei Wang Xun Lei Pedro A Jose Chunyan Deng Jian Yang Source Type: research

Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na < sup > + < /sup > excretion and insulin resistance
CONCLUSION: Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function.PMID:37943619 | DOI:10.1080/10641963.2023.2276029 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 9, 2023 Category: Cardiology Authors: Xiaoxin Zhou Longlong Zhang Xiaoqian Lin Xi Chen Hong Liu Xiaoli Yuan Qiuxia Zhao Weiwei Wang Xun Lei Pedro A Jose Chunyan Deng Jian Yang Source Type: research

Calcitriol reverses age-related hypertension via downregulating renal AP1/AT < sub > 1 < /sub > R pathway through regulating mitochondrial function
CONCLUSIONS: Our findings indicated that calcitriol reversed age-related hypertension via downregulating renal AP1/AT1R pathway through regulating mitochondrial function. Thus, calcitriol may be a valuable therapeutic strategy for age-related hypertension.PMID:37939250 | DOI:10.1080/10641963.2023.2277653 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 8, 2023 Category: Cardiology Authors: Ruifang Hua Baixiong Liu Wenxiu He Huilin Zhang Yong Liu Qiang Xie Linjun Zhou Fang Pei Source Type: research

Calcitriol reverses age-related hypertension via downregulating renal AP1/AT < sub > 1 < /sub > R pathway through regulating mitochondrial function
CONCLUSIONS: Our findings indicated that calcitriol reversed age-related hypertension via downregulating renal AP1/AT1R pathway through regulating mitochondrial function. Thus, calcitriol may be a valuable therapeutic strategy for age-related hypertension.PMID:37939250 | DOI:10.1080/10641963.2023.2277653 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - November 8, 2023 Category: Cardiology Authors: Ruifang Hua Baixiong Liu Wenxiu He Huilin Zhang Yong Liu Qiang Xie Linjun Zhou Fang Pei Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
CONCLUSIONS: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.PMID:37902269 | DOI:10.1080/10641963.2023.2272581 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 30, 2023 Category: Cardiology Authors: Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu Source Type: research

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells
CONCLUSIONS AND IMPLICATIONS: SERCA2 dysfunction promotes PASMC phenotypic transition and pulmonary vascular remodeling by multiple mechanisms, which could be improved by SERCA2 agonist CDN1163.PMID:37899350 | DOI:10.1080/10641963.2023.2272062 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 29, 2023 Category: Cardiology Authors: Weimin Yu Qian Zhang Yixiang Qiu Hui Chen Xiaoyang Huang Li Xiao Gang Xu Siqi Li Pingping Hu Xiaoyong Tong Source Type: research

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells
CONCLUSIONS AND IMPLICATIONS: SERCA2 dysfunction promotes PASMC phenotypic transition and pulmonary vascular remodeling by multiple mechanisms, which could be improved by SERCA2 agonist CDN1163.PMID:37899350 | DOI:10.1080/10641963.2023.2272062 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 29, 2023 Category: Cardiology Authors: Weimin Yu Qian Zhang Yixiang Qiu Hui Chen Xiaoyang Huang Li Xiao Gang Xu Siqi Li Pingping Hu Xiaoyong Tong Source Type: research

RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling
Conclusion: Our findings reveal the modulatory role of RGS10 in PASMC and PH via AKT/mTORC1 axis. Therefore, targeting RGS10 may serve as a novel potent method for the prevention against PH."PMID:37879890 | DOI:10.1080/10641963.2023.2271186 (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - October 25, 2023 Category: Cardiology Authors: Sheng Hu Yijie Zhang Chenming Qiu Ying Li Source Type: research