A case of pseudo-Bartter/Gitelman syndrome caused by long-term laxative abuse, leading to end-stage kidney disease
We report the first case of PBS/PGS due to long-term laxative abuse leading to end-stage kidney disease (ESKD). The patient was a 49-year-old woman with a history of constipation since school, who had used excessive doses of laxatives on her own judgment for nine years at least from 22 years of age. Two years later, blood tests revealed hypokalemia (serum K 3.1 mEq/L), and nine years later, the patient’s renal function began to deteriorate (Cr-eGFR 48.7 mL/min/1.73 m2). Since abuse of laxatives was suspected as the cause, it was changed to the proper dosage of laxatives. At 33 years, the patient developed acute kid...
Source: CEN Case Reports - February 2, 2024 Category: Urology & Nephrology Source Type: research
Mucormycosis-induced hypercalcemia: a case report
AbstractHypercalcemia is a vital laboratory marker because it can show underlying severe diseases like cancer and infections. Of all the causes of hypercalcemia, primary hyperparathyroidism, and malignancies are the most common, but granulomatous diseases, such as certain fungal infections, can also be the cause. Here we describe the case of a 29-year-old woman, an insulin-dependent diabetic, found unconscious and tachypneic at home. In the emergency room, the medical team diagnosed diabetic ketoacidosis (DKA) and acute kidney injury (AKI). During hospitalization, despite resolving acidemia, persistent hypercalcemia attrac...
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Relapse of minimal change disease following the third mRNA COVID-19 vaccination: a case report and literature review
AbstractMass vaccination is the most important strategy to terminate the coronavirus disease 2019 (COVID-19) pandemic. Reports suggest the potential risk of the development of new-onset or relapse of minimal change disease (MCD) following COVID-19 vaccination; however, details on vaccine-associated MCD remain unclear. A 43-year-old man with MCD, who had been in remission for 29 years, developed nephrotic syndrome 4 days after receiving the third dose of the Pfizer-BioNTech vaccine. His kidney biopsy revealed relapsing MCD. Intravenous methylprednisolone pulse therapy followed by oral prednisolone therapy was administere...
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Fatal acute portal vein thrombosis associated with hepatic cysts in a patient with autosomal dominant polycystic kidney disease
In conclusion, this is the first paper to report on the involvement of APVT in patients with PLD. (Source: CEN Case Reports)
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Dapagliflozin induced hypernatremia via osmotic diuresis: a case report
AbstractSodium-glucose cotransporter 2 (SGLT2) inhibitors have been widely used. They inhibit proximal tubular glucose reabsorption, resulting in glycosuria. Herein, we report the case of a 65-year-old woman who presented with hypernatremia during the perioperative period of a subarachnoid hemorrhage. The patient continued to take dapagliflozin postoperatively and subsequently developed severe hypernatremia. Based on the urinalysis findings, we diagnosed osmotic diuresis due to glycosuria as contributing to hypernatremia. Hypernatremia improved with the discontinuation of dapagliflozin and the administration of a hypotonic...
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
The role of follicular helper T cells in the pathogenesis of allergic disease-related minimal change nephrotic syndrome
(Source: CEN Case Reports)
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Normalization of progressive increases in serum myeloperoxidase –anti-neutrophil cytoplasmic antibody titers after breast cancer resection in a patient with clinically stable microscopic polyangiitis
(Source: CEN Case Reports)
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Comments and suggestions to the article, titled “IgA‑dominant infection‑related glomerulonephritis with NAPlr‑positive tubulointerstitial nephritis”
(Source: CEN Case Reports)
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Tubulointerstitial nephritis as a rare manifestation of ANCA-associated vasculitis: the challenge for its diagnosis and classification
(Source: CEN Case Reports)
Source: CEN Case Reports - February 1, 2024 Category: Urology & Nephrology Source Type: research
Lupus-like membranous nephropathy during the postpartum period expressing glomerular antigens exostosin 1/exostosin 2 and phospholipase A2 receptor: a case report
AbstractRecently, several target antigens of membranous nephropathy (MN), such as phospholipase A2 receptor (PLA2R) and exostosin 1/exostosin 2 (EXT1/2), have been discovered. A 30-year-old woman was referred to our hospital with nephrotic range proteinuria and microscopic hematuria. She was first noted to have proteinuria before pregnancy, and her proteinuria worsened in the postpartum period. A renal biopsy showed MN. Immunofluorescence microscopy showed IgG, IgA, IgM, C3, C4, and C1q depositions in the mesangial area and glomerular capillary walls (GCWs). Regarding the IgG subclass, IgG1 and IgG3 were detected on glomer...
Source: CEN Case Reports - January 27, 2024 Category: Urology & Nephrology Source Type: research
Hypereosinophilia-associated acute intradialytic hypotension: a report of three cases and literature review
AbstractOccasionally, patients undergoing dialysis develop acute severe hypotension that requires interruption of dialysis within minutes of initiating every dialysis session. Although the underlying causes of recurrent intradialytic hypotension are evaluated extensively, including dialysis-associated allergic reactions or other possible causes, the definitive cause is sometimes missed. Dialysis is a life-sustaining procedure; therefore, prompt identification and management of the underlying cause of dialysis intolerance are crucial. Herein, we report three cases of patients undergoing dialysis who presented with hypereosi...
Source: CEN Case Reports - January 26, 2024 Category: Urology & Nephrology Source Type: research
An unusual cause of renal vein thrombosis in a newborn: COVID-19
AbstractThere is no information on renal vein thrombosis induced by COVID-19 infection in a neonate. Few cases of renal vein thrombosis caused by COVID-19 infection have been reported in predominantly adult patients. On day 25 after birth, a newborn whose mother was infected with COVID-19 had renal vein thrombosis. We believed that our patient ’s renal vein thrombosis was caused by postnatal transmission of the COVID-19 infection that the mother had acquired during birth. The clinical and radiologic findings of these unusual renal complications in a neonate, as well as treatment options, are presented. (Source: CEN Case Reports)
Source: CEN Case Reports - January 8, 2024 Category: Urology & Nephrology Source Type: research
Correction to: Functional changes in the heart after sacubitril/valsartan use in 5 hemodialysis patients with hypertension. Case report
(Source: CEN Case Reports)
Source: CEN Case Reports - December 28, 2023 Category: Urology & Nephrology Source Type: research
Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy
AbstractThe understanding of membranous nephropathy (MN) has undergone impressive advancements in the last 5 years, particularly due to identification of novel antigenic targets. M-type phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) account for approximately 70% and 1–5% of the target antigens in primary MN, respectively. Recently, more novel/putative antigens have been identified in the remaining cases of MN that include exostosin 1/exostosin 2 (EXT1/EXT2), neural epidermal growth factor-like 1 protein (NELL-1), semaphorin 3B (SEMA3B) and protocadherin 7 (PCDH7). However, com...
Source: CEN Case Reports - December 25, 2023 Category: Urology & Nephrology Source Type: research
