A case of paraneoplastic IgA nephropathy with glomerular capillary IgA and galactose-deficient IgA1 deposition
AbstractParaneoplastic IgA nephropathy (IgAN) is an underrecognized condition in which malignancy manifests as symptoms of IgAN, and it remains controversial regarding their mechanistic relation between IgAN and malignancy. Herein, we report a case of a 68-year-old Japanese man with glottic cancer who developed nephrotic syndrome as a clinical manifestation of IgAN. Renal biopsy revealed diffuse proliferative glomerulonephritis with glomerular capillary IgA deposition that is a rare subtype of IgAN. After complete remission of the glottic cancer by irradiation, proteinuria and hematuria disappeared. Based on his clinical c...
Source: CEN Case Reports - July 11, 2023 Category: Urology & Nephrology Source Type: research
Successful treatment of coexisting membranous nephropathy and immune thrombocytopenia by eradicating gastric Helicobacter pylori infection: a case report
We present the case of a 52-year-old Japanese man with coexisting nephrotic MN and immune thrombocytopenic purpura (ITP). Renal biopsy revealed glomerular basement membrane thickening with immunoglobulin (Ig) G and complement component 3 deposition. Glomerular IgG subclass analysis revealed predominant IgG4 deposition with weak IgG1 and IgG2 deposition. IgG3 and phospholipase A2 receptor deposits were negative. Upper endoscopy revealed no ulcers, but histological examination demonstratedHelicobacter pylori infection in the gastric mucosa with elevated IgG antibodies. After gastricHelicobacter pylori eradication, the nephro...
Source: CEN Case Reports - July 8, 2023 Category: Urology & Nephrology Source Type: research
Distal renal tubular acidosis as presenting manifestation of Wilson disease in a 11-year-old girl
AbstractA 11-year-old girl was referred to the pediatric nephrology services of our hospital for evaluation of vitamin-D-refractory rickets. She was born to second-degree consanguineous parents. On examination, she had wrist widening and bilateral genu varum. She had normal anion gap metabolic acidosis, hypokalemia, and hyperchloremia. The fractional excretion of bicarbonate was 3% and the urine anion gap was positive. She also had hypercalciuria, but no phosphaturia, glucosuria or aminoaciduria. In view of a family history of an elder sister having rigidity with cognitive and speech impairment, an ophthalmic evaluation by...
Source: CEN Case Reports - July 6, 2023 Category: Urology & Nephrology Source Type: research
Nephrotic “full-house” glomerulonephritis successfully treated with antibiotics alone in secondary syphilis: a case report
AbstractA Japanese female in her twenties developed general edema with heavy proteinuria, and was referred to our hospital. She exhibited the common clinical manifestation of idiopathic nephrotic syndrome with massive proteinuria (20.37 g/day), hypoalbuminemia (1.8 g/dL), and hypercholesterolemia (300 mg/dL). Routine admission tests were positive results for both the rapid plasma reagin latex agglutination test for syphilis (RPR) and theTreponema pallidum particle agglutination assay (TPHA). As such, we made her a diagnosis of nephrotic syndrome due to secondary syphilis. Renal biopsy revealed “full-house” nephropa...
Source: CEN Case Reports - June 23, 2023 Category: Urology & Nephrology Source Type: research
Adult-onset carnitine palmitoyl transferase II (CPT II) deficiency presenting with rhabdomyolysis and acute kidney injury
AbstractMetabolic myopathies are among the treatable causes of rhabdomyolysis and myoglobinuria. Carnitine palmitoyl transferase 2 (CPT II) deficiency is one of the most common causes of recurrent myoglobinuria in adults. It is an inherited disorder of fatty acid oxidation pathway, commonly associated with elevated acylcarnitine levels. In this case report, we present a 49-year-old male patient who developed acute kidney injury after rhabdomyolysis and was thus diagnosed with CPT2 deficiency after his first episode of rhabdomyolysis. Inborn errors of metabolism should be kept in mind in patients with rhabdomyolysis. Acylca...
Source: CEN Case Reports - June 21, 2023 Category: Urology & Nephrology Source Type: research
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(Source: CEN Case Reports)
Source: CEN Case Reports - June 13, 2023 Category: Urology & Nephrology Source Type: research
Mucormycosis-induced hypercalcemia: a case report
AbstractHypercalcemia is a vital laboratory marker because it can show underlying severe diseases like cancer and infections. Of all the causes of hypercalcemia, primary hyperparathyroidism, and malignancies are the most common, but granulomatous diseases, such as certain fungal infections, can also be the cause. Here we describe the case of a 29-year-old woman, an insulin-dependent diabetic, found unconscious and tachypneic at home. In the emergency room, the medical team diagnosed diabetic ketoacidosis (DKA) and acute kidney injury (AKI). During hospitalization, despite resolving acidemia, persistent hypercalcemia attrac...
Source: CEN Case Reports - June 8, 2023 Category: Urology & Nephrology Source Type: research
Profound metabolic acidosis in association with sodium thiosulfate therapy in a patient with calcific uremic arteriolopathy: a case report and literature review
AbstractCalciphylaxis, also known as Calcific uremic arteriolopathy (CUA), is a serious disorder that presents with skin necrosis due to calcification of dermal and subcutaneous adipose tissue capillaries and arterioles. The condition occurs primarily in patients with end-stage renal disease (ESRD) on dialysis, and it carries high morbidity and mortality, primarily due to sepsis, with an estimated six-month survival of approximately 50%. Although there are no high-quality studies to guide the optimal treatment approach for patients with calciphylaxis, many retrospective studies and case series support treatment with sodium...
Source: CEN Case Reports - June 5, 2023 Category: Urology & Nephrology Source Type: research
Relapse of minimal change disease following the third mRNA COVID-19 vaccination: a case report and literature review
AbstractMass vaccination is the most important strategy to terminate the coronavirus disease 2019 (COVID-19) pandemic. Reports suggest the potential risk of the development of new-onset or relapse of minimal change disease (MCD) following COVID-19 vaccination; however, details on vaccine-associated MCD remain unclear. A 43-year-old man with MCD, who had been in remission for 29 years, developed nephrotic syndrome 4 days after receiving the third dose of the Pfizer-BioNTech vaccine. His kidney biopsy revealed relapsing MCD. Intravenous methylprednisolone pulse therapy followed by oral prednisolone therapy was administere...
Source: CEN Case Reports - May 27, 2023 Category: Urology & Nephrology Source Type: research
Granulocyte-colony stimulating factor producing cervical cancer with elevated levels of parathyroid hormone-related protein: a case report and literature review
AbstractSystemic effects associated with hormones and cytokines secreted by tumor cells can cause paraneoplastic syndrome. Leukemoid reactions and hypercalcemia are relatively common manifestations of paraneoplastic syndrome. Here, we describe the case of a 90-year-old woman who presented with leukocytosis and hypercalcemia and was diagnosed with granulocyte-colony stimulating factor (G-CSF)-producing cervical cancer with elevated levels of parathyroid hormone-related protein (PTHrP). The patient visited our hospital complaining of general fatigue and anorexia. On admission, she presented with marked leukocytosis, hypercal...
Source: CEN Case Reports - May 25, 2023 Category: Urology & Nephrology Source Type: research
Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review
AbstractThe coexistence of anti-glomerular basement membrane (anti-GBM) disease with thrombotic microangiopathy (TMA) is rarely encountered, and the clinical characteristics of this phenomenon are not well known.A 76-year-old Japanese woman with a history of idiopathic pulmonary disease was diagnosed with anti-GBM disease due to rapidly progressive glomerulonephritis and a positive anti-GBM antibody test result. We treated the patient with hemodialysis, glucocorticoids, and plasmapheresis. During treatment, the patient suddenly became comatose. TMA was then diagnosed because of thrombocytopenia and microangiopathic hemolyt...
Source: CEN Case Reports - May 22, 2023 Category: Urology & Nephrology Source Type: research
Tubulointerstitial nephritis as a rare manifestation of ANCA-associated vasculitis: the challenge for its diagnosis and classification
(Source: CEN Case Reports)
Source: CEN Case Reports - May 22, 2023 Category: Urology & Nephrology Source Type: research
Normalization of progressive increases in serum myeloperoxidase –anti-neutrophil cytoplasmic antibody titers after breast cancer resection in a patient with clinically stable microscopic polyangiitis
(Source: CEN Case Reports)
Source: CEN Case Reports - May 11, 2023 Category: Urology & Nephrology Source Type: research
Fatal acute portal vein thrombosis associated with hepatic cysts in a patient with autosomal dominant polycystic kidney disease
In conclusion, this is the first paper to report on the involvement of APVT in patients with PLD. (Source: CEN Case Reports)
Source: CEN Case Reports - May 10, 2023 Category: Urology & Nephrology Source Type: research
The role of follicular helper T cells in the pathogenesis of allergic disease-related minimal change nephrotic syndrome
(Source: CEN Case Reports)
Source: CEN Case Reports - May 8, 2023 Category: Urology & Nephrology Source Type: research
