Fatal acute portal vein thrombosis associated with hepatic cysts in a patient with autosomal dominant polycystic kidney disease
In conclusion, this is the first paper to report on the involvement of APVT in patients with PLD. (Source: CEN Case Reports)
Source: CEN Case Reports - May 10, 2023 Category: Urology & Nephrology Source Type: research
The role of follicular helper T cells in the pathogenesis of allergic disease-related minimal change nephrotic syndrome
(Source: CEN Case Reports)
Source: CEN Case Reports - May 8, 2023 Category: Urology & Nephrology Source Type: research
Early diagnosis leading to improvement of critical illness polyneuropathy associated with severe Staphylococcus aureus infection in a patient on hemodialysis
AbstractCritical illness polyneuropathy (CIP) is a very rare complication of sepsis and multi-organ failure. Herein, we report the first case of CIP reported in a patient on maintenance hemodialysis, who improved with rehabilitation. A 55-year-old male patient was emergently admitted with fever and altered consciousness and diagnosed with bacterial meningitis based on cerebral spinal fluid and cranial magnetic resonance imaging findings. Methicillin-susceptibleStaphylococcus aureus was detected in blood and cerebral spinal fluid cultures. Despite treatment with appropriate antibiotics, blood cultures were positive for 9 ...
Source: CEN Case Reports - April 29, 2023 Category: Urology & Nephrology Source Type: research
A case of rapidly progressive glomerulonephritis with double-positive anti-GBM antibody and MPO-ANCA after SARS-CoV-2 vaccination and relapse during 1 year follow-up
In this report, we describe a case of rapidly progressive glomerulonephritis that developed after SARS-CoV-2 vaccination, in which both anti-glomerular basement membrane (anti-GBM) and myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) were present. The patient ’s renal biopsy showed that of the 48 glomeruli in total, four showed global sclerosis and none showed segmental sclerosis. The biopsy showed 11 cellular glomerular crescents and 5 fibrocellular glomerular crescents. Renal function improved with steroids, rituximab, and plasma exchange. Approximat ely 9 months later, MPO-ANCA was again elevated, and...
Source: CEN Case Reports - April 27, 2023 Category: Urology & Nephrology Source Type: research
IgA nephropathy in a boy with frequently relapsing nephrotic syndrome
AbstractA Japanese boy developed nephrotic syndrome (NS) and had microscopic hematuria at 8 years old. Renal biopsy was performed. Light microscopy study revealed mesangial proliferation and all immunofluorescent stains (including IgA) were negative, so he was diagnosed with non-IgA diffuse mesangial proliferation (DMP). Complete remission was achieved at 13 days after the initiation of oral prednisolone, and hematuria also disappeared 3 days later, but the patient developed frequently relapsing nephrotic syndrome. Cyclosporine A (CyA) was introduced at 10 years old, and there were no relapses between then and when it ...
Source: CEN Case Reports - April 24, 2023 Category: Urology & Nephrology Source Type: research
Hepatitis E virus infection-induced complete remission of primary membranous nephropathy through its higher propensity for inducing regulatory T cells
(Source: CEN Case Reports)
Source: CEN Case Reports - April 24, 2023 Category: Urology & Nephrology Source Type: research
Dapagliflozin induced hypernatremia via osmotic diuresis: a case report
AbstractSodium-glucose cotransporter 2 (SGLT2) inhibitors have been widely used. They inhibit proximal tubular glucose reabsorption, resulting in glycosuria. Herein, we report the case of a 65-year-old woman who presented with hypernatremia during the perioperative period of a subarachnoid hemorrhage. The patient continued to take dapagliflozin postoperatively and subsequently developed severe hypernatremia. Based on the urinalysis findings, we diagnosed osmotic diuresis due to glycosuria as contributing to hypernatremia. Hypernatremia improved with the discontinuation of dapagliflozin and the administration of a hypotonic...
Source: CEN Case Reports - April 19, 2023 Category: Urology & Nephrology Source Type: research
Comments and suggestions to the article, titled “IgA‑dominant infection‑related glomerulonephritis with NAPlr‑positive tubulointerstitial nephritis”
(Source: CEN Case Reports)
Source: CEN Case Reports - April 8, 2023 Category: Urology & Nephrology Source Type: research
A case of primary aldosteronism with excessive secretion of renin that was unmasked by kidney transplantation
AbstractA 42-year-old man showed marked hypokalemia after kidney transplantation. He was diagnosed with hypertension and suffered from acute myocardial infarction at 33 and 38 years of age. At 40 years of age, hemodialysis was introduced. A left adrenal tumor was noted and suspected as a non-functional adrenal adenoma at that time. Therefore, he received a living-donor kidney transplant at 42 years of age. After kidney transplantation, the serum creatinine level drop ped. His blood pressure remained high, and the serum potassium level decreased. The PRA and PAC were elevated, and ARR was not elevated. Based on the res...
Source: CEN Case Reports - April 3, 2023 Category: Urology & Nephrology Source Type: research
Successful administration of eltrombopag in preparation for peritoneal dialysis catheter placement in a girl with MYH9-related disease
AbstractMYH9-related disease is an autosomal dominant disorder characterized by macrothrombocytopenia, nephropathy, inclusion bodies in leukocytes, sensorineural hearing loss, and cataract. Severe cases require kidney replacement therapy in the patient ’s second decade of life; thrombocytopenia constitutes a major risk factor for hemorrhagic complications during dialysis initiation or kidney transplantation. Prophylactic platelet transfusion prior to surgery is commonly administered to affected patients in these cases. However, transfusion in su ch patients has limitations other than the general risk of allergic reaction...
Source: CEN Case Reports - March 31, 2023 Category: Urology & Nephrology Source Type: research
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature
In this study, we present a 70-day-old Iranian female patient from consanguineous parents with hypomagnesemia and secondary hypocalcemia. She presented with seizures 19 days after birth and refractory watery non-bloody diarrhea. She consequently had failure to thrive. Other features included hypotonia, wide anterior fontanel, ventriculomegaly, and pseudotumor cerebri following administration of nalidixic acid. She had severe hypomagnesemia and hypocalcemia which were treated with magnesium and calcium supplementation. Despite initial unstable response to supplemental magnesium, she eventually improved and the diarrhea di...
Source: CEN Case Reports - March 26, 2023 Category: Urology & Nephrology Source Type: research
Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose
AbstractMetformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported. Here we report a case of lactic acidosis and euDKA after metformin overdose. A 57-year-old female patient was transferred to our hospital with severe metabolic acidosis and acute kidney injury. She had type 2 diabetes mellitus and was on oral antidiabetic therapy of vildagliptin metformin hydrochloride daily. On the admission day, she had committed suicide by overdosing 50 tablets of vildagliptin metformin hydrochloride, which was equiv...
Source: CEN Case Reports - March 19, 2023 Category: Urology & Nephrology Source Type: research
IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis
We report a case of methicillin-sensitiveStaphylococcus aureus (MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and dr...
Source: CEN Case Reports - March 15, 2023 Category: Urology & Nephrology Source Type: research
Marked hyperkalemia due to inappropriate blood sample storage in two suspected cases of familial pseudohyperkalemia
AbstractWe herein report two suspected cases of pseudohyperkalemia who presented with severe hyperkalemia examined at small primary care clinics; however, re-exams at a tertiary care hospital showed normal potassium levels. We reproduced the laboratory examination conditions of the clinics and found that hyperkalemia was due to sampling/storage condition of serum, which is strongly suggestive of familial pseudohyperkalemia (FP). FP is a possible but under-appreciated cause of hyperkalemia, which does not require treatment, so it is important to include FP in the differential diagnosis of hyperkalemia especially in cases wi...
Source: CEN Case Reports - March 12, 2023 Category: Urology & Nephrology Source Type: research
A case of hemophagocytic lymphohistiocytosis in a hemodialysis patient with coronavirus disease 2019
AbstractDuring the treatment of a patient on hemodialysis with severe coronavirus disease 2019 (COVID-19), the patient was weaned from extracorporeal membrane oxygenation, which was used to treat severe COVID-19 pneumonia. However, the patient ’s condition worsened after the peak infection phase of COVID-19 because of acute respiratory distress syndrome with suspected hemophagocytic lymphohistiocytosis (HLH). After a bone marrow biopsy confirmed the diagnosis, methylprednisolone pulse therapy, followed by combination therapy (including oral prednisolone and cyclosporine) was immediately administered, and the patient surv...
Source: CEN Case Reports - March 3, 2023 Category: Urology & Nephrology Source Type: research
