Promises and challenges of organoids: From humanized to human derived
Cell Stem Cell. 2024 Mar 7;31(3):281-282. doi: 10.1016/j.stem.2024.02.002.ABSTRACTKastenschmidt et al.1 present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells.PMID:38458173 | DOI:10.1016/j.stem.2024.02.002 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Wenyan Wang Yang-Xin Fu Source Type: research
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids
Cell Stem Cell. 2024 Mar 7;31(3):283-284. doi: 10.1016/j.stem.2024.02.008.ABSTRACTDissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.PMID:38458174 | DOI:10.1016/j.stem.2024.02.008 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Eduardo Leyva-D íaz Emily S Wilson Guillermina L ópez-Bendito Source Type: research
From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors
Cell Stem Cell. 2024 Mar 7;31(3):285-287. doi: 10.1016/j.stem.2024.02.003.ABSTRACTAiming to improve the effector function of CAR-T cells, Zhao et al.1 report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.PMID:38458175 | DOI:10.1016/j.stem.2024.02.003 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Yuwei Huang Haopeng Wang Source Type: research
KOLF2.1J iPSCs carry CNVs associated with neurodevelopmental disorders
Cell Stem Cell. 2024 Mar 7;31(3):288-289. doi: 10.1016/j.stem.2024.02.007.NO ABSTRACTPMID:38458176 | DOI:10.1016/j.stem.2024.02.007 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Carolina Gracia-Diaz Jonathan E Perdomo Munir E Khan Thomas Roule Brianna L Disanza Gregory G Cajka Sunyimeng Lei Alyssa L Gagne Jean Ann Maguire Ophir Shalem Elizabeth J Bhoj Rebecca C Ahrens-Nicklas Deborah L French Ethan M Goldberg Kai Wang Joseph T Gl Source Type: research
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modeling
Cell Stem Cell. 2024 Mar 7;31(3):290-291. doi: 10.1016/j.stem.2024.02.006.NO ABSTRACTPMID:38458177 | DOI:10.1016/j.stem.2024.02.006 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Mallory Ryan Justin A McDonough Michael E Ward Mark R Cookson William C Skarnes Florian T Merkle Source Type: research
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004.ABSTRACTMitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, which are required for proper HSC cell fate and homeostasis. Bioinformatic analysis of the HSC transcriptome, biochemical assays, and genetic inactivation of FAO all indicate that FAO-generated NADPH fuels cholesterol synthesis in HSCs. Interferenc...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Massimo Bonora Claudia Morganti Nick van Gastel Kyoko Ito Enrica Calura Ilaria Zanolla Letizia Ferroni Yang Zhang Yookyung Jung Gabriele Sales Paolo Martini Takahisa Nakamura Francesco Massimo Lasorsa Toren Finkel Charles P Lin Barbara Zavan Paolo Pinton Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Promises and challenges of organoids: From humanized to human derived
Cell Stem Cell. 2024 Mar 7;31(3):281-282. doi: 10.1016/j.stem.2024.02.002.ABSTRACTKastenschmidt et al.1 present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells.PMID:38458173 | DOI:10.1016/j.stem.2024.02.002 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Wenyan Wang Yang-Xin Fu Source Type: research
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids
Cell Stem Cell. 2024 Mar 7;31(3):283-284. doi: 10.1016/j.stem.2024.02.008.ABSTRACTDissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.PMID:38458174 | DOI:10.1016/j.stem.2024.02.008 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Eduardo Leyva-D íaz Emily S Wilson Guillermina L ópez-Bendito Source Type: research
From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors
Cell Stem Cell. 2024 Mar 7;31(3):285-287. doi: 10.1016/j.stem.2024.02.003.ABSTRACTAiming to improve the effector function of CAR-T cells, Zhao et al.1 report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.PMID:38458175 | DOI:10.1016/j.stem.2024.02.003 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Yuwei Huang Haopeng Wang Source Type: research
KOLF2.1J iPSCs carry CNVs associated with neurodevelopmental disorders
Cell Stem Cell. 2024 Mar 7;31(3):288-289. doi: 10.1016/j.stem.2024.02.007.NO ABSTRACTPMID:38458176 | DOI:10.1016/j.stem.2024.02.007 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Carolina Gracia-Diaz Jonathan E Perdomo Munir E Khan Thomas Roule Brianna L Disanza Gregory G Cajka Sunyimeng Lei Alyssa L Gagne Jean Ann Maguire Ophir Shalem Elizabeth J Bhoj Rebecca C Ahrens-Nicklas Deborah L French Ethan M Goldberg Kai Wang Joseph T Gl Source Type: research
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modeling
Cell Stem Cell. 2024 Mar 7;31(3):290-291. doi: 10.1016/j.stem.2024.02.006.NO ABSTRACTPMID:38458177 | DOI:10.1016/j.stem.2024.02.006 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Mallory Ryan Justin A McDonough Michael E Ward Mark R Cookson William C Skarnes Florian T Merkle Source Type: research
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
Cell Stem Cell. 2024 Mar 7;31(3):359-377.e10. doi: 10.1016/j.stem.2024.02.004.ABSTRACTMitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, which are required for proper HSC cell fate and homeostasis. Bioinformatic analysis of the HSC transcriptome, biochemical assays, and genetic inactivation of FAO all indicate that FAO-generated NADPH fuels cholesterol synthesis in HSCs. Interferenc...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Massimo Bonora Claudia Morganti Nick van Gastel Kyoko Ito Enrica Calura Ilaria Zanolla Letizia Ferroni Yang Zhang Yookyung Jung Gabriele Sales Paolo Martini Takahisa Nakamura Francesco Massimo Lasorsa Toren Finkel Charles P Lin Barbara Zavan Paolo Pinton Source Type: research
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure
Cell Stem Cell. 2024 Feb 27:S1934-5909(24)00048-1. doi: 10.1016/j.stem.2024.02.005. Online ahead of print.ABSTRACTAlginate-encapsulated hepatocyte transplantation is a promising strategy to treat liver failure. However, its clinical application was impeded by the lack of primary human hepatocytes and difficulty in controlling their quality. We previously reported proliferating human hepatocytes (ProliHHs). Here, quality-controlled ProliHHs were produced in mass and engineered as liver organoids to improve their maturity. Encapsulated ProliHHs liver organoids (eLO) were intraperitoneally transplanted to treat liver failure ...
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Xiang Yuan Jingqi Wu Zhen Sun Jin Cen Yajing Shu Chenhua Wang Hong Li Dongni Lin Kun Zhang Baihua Wu Anil Dhawan Ludi Zhang Lijian Hui Source Type: research
Promises and challenges of organoids: From humanized to human derived
Cell Stem Cell. 2024 Mar 7;31(3):281-282. doi: 10.1016/j.stem.2024.02.002.ABSTRACTKastenschmidt et al.1 present a groundbreaking organoid culture model for follicular lymphoma, which is capable of maintaining stable compositions of B and T cells. This model is utilized in testing bispecific antibodies in effective killing of tumor B cells with the activation of T cells.PMID:38458173 | DOI:10.1016/j.stem.2024.02.002 (Source: Cell Stem Cell)
Source: Cell Stem Cell - March 8, 2024 Category: Stem Cells Authors: Wenyan Wang Yang-Xin Fu Source Type: research
