From suppressor to enhancer: IL-10's alternative role in CAR-T cell therapies against solid tumors

Cell Stem Cell. 2024 Mar 7;31(3):285-287. doi: 10.1016/j.stem.2024.02.003.ABSTRACTAiming to improve the effector function of CAR-T cells, Zhao et al.1 report that IL-10 metabolically reprograms CAR-T cells, and this promotes their effectiveness against solid tumors and challenges IL-10's perceived role as merely immunosuppressive. This simple but promising strategy fosters durable immune memory and eagerly awaits validation in clinical trials.PMID:38458175 | DOI:10.1016/j.stem.2024.02.003
Source: Cell Stem Cell - Category: Stem Cells Authors: Source Type: research