Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
Cell Metab. 2024 Apr 3:S1550-4131(24)00089-5. doi: 10.1016/j.cmet.2024.03.010. Online ahead of print.ABSTRACTThe gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestin...
Source: Cell Metabolism - April 6, 2024 Category: Cytology Authors: Mingliang Zhao Zhenxing Ren Aihua Zhao Yajun Tang Junliang Kuang Mengci Li Tianlu Chen Shouli Wang Jieyi Wang Huiheng Zhang Jijun Wang Tianhong Zhang Jiahui Zeng Xiaohua Liu Guoxiang Xie Penghong Liu Ning Sun Tianhao Bao Tongtong Nie Jingchao Lin Ping Liu Source Type: research
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
Cell Metab. 2024 Apr 3:S1550-4131(24)00089-5. doi: 10.1016/j.cmet.2024.03.010. Online ahead of print.ABSTRACTThe gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestin...
Source: Cell Metabolism - April 6, 2024 Category: Cytology Authors: Mingliang Zhao Zhenxing Ren Aihua Zhao Yajun Tang Junliang Kuang Mengci Li Tianlu Chen Shouli Wang Jieyi Wang Huiheng Zhang Jijun Wang Tianhong Zhang Jiahui Zeng Xiaohua Liu Guoxiang Xie Penghong Liu Ning Sun Tianhao Bao Tongtong Nie Jingchao Lin Ping Liu Source Type: research
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
Cell Metab. 2024 Apr 3:S1550-4131(24)00089-5. doi: 10.1016/j.cmet.2024.03.010. Online ahead of print.ABSTRACTThe gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation. This highlights a synergistic interaction among gut microbiota in regulating intestin...
Source: Cell Metabolism - April 6, 2024 Category: Cytology Authors: Mingliang Zhao Zhenxing Ren Aihua Zhao Yajun Tang Junliang Kuang Mengci Li Tianlu Chen Shouli Wang Jieyi Wang Huiheng Zhang Jijun Wang Tianhong Zhang Jiahui Zeng Xiaohua Liu Guoxiang Xie Penghong Liu Ning Sun Tianhao Bao Tongtong Nie Jingchao Lin Ping Liu Source Type: research
An integrated multi-omics analysis reveals osteokines involved in global regulation
In this study, we analyzed bone and extraskeletal tissues, osteoblast (OB) conditioned media, bone marrow supernatant (BMS), and serum, for basal osteokines and those responsive to aging and mechanical loading/unloading. We identified 375 candidate osteokines and their changes in response to aging and mechanical dynamics by integrating data from RNA-seq, scRNA-seq, and proteomic approaches. Furthermore, we analyzed their cellular sources in the bone and inter-organ communication facilitated by them (bone-brain, liver, and aorta). Notably, we discovered that senescent OBs secrete fatty-acid-binding protein 3 to propagate se...
Source: Cell Metabolism - April 4, 2024 Category: Cytology Authors: Wenquan Liang Tiantian Wei Le Hu Meijun Chen Liping Tong Wu Zhou Xingwei Duan Xiaoyang Zhao Weijie Zhou Qing Jiang Guozhi Xiao Weiguo Zou Di Chen Zhipeng Zou Xiaochun Bai Source Type: research
An integrated multi-omics analysis reveals osteokines involved in global regulation
In this study, we analyzed bone and extraskeletal tissues, osteoblast (OB) conditioned media, bone marrow supernatant (BMS), and serum, for basal osteokines and those responsive to aging and mechanical loading/unloading. We identified 375 candidate osteokines and their changes in response to aging and mechanical dynamics by integrating data from RNA-seq, scRNA-seq, and proteomic approaches. Furthermore, we analyzed their cellular sources in the bone and inter-organ communication facilitated by them (bone-brain, liver, and aorta). Notably, we discovered that senescent OBs secrete fatty-acid-binding protein 3 to propagate se...
Source: Cell Metabolism - April 4, 2024 Category: Cytology Authors: Wenquan Liang Tiantian Wei Le Hu Meijun Chen Liping Tong Wu Zhou Xingwei Duan Xiaoyang Zhao Weijie Zhou Qing Jiang Guozhi Xiao Weiguo Zou Di Chen Zhipeng Zou Xiaochun Bai Source Type: research
An integrated multi-omics analysis reveals osteokines involved in global regulation
In this study, we analyzed bone and extraskeletal tissues, osteoblast (OB) conditioned media, bone marrow supernatant (BMS), and serum, for basal osteokines and those responsive to aging and mechanical loading/unloading. We identified 375 candidate osteokines and their changes in response to aging and mechanical dynamics by integrating data from RNA-seq, scRNA-seq, and proteomic approaches. Furthermore, we analyzed their cellular sources in the bone and inter-organ communication facilitated by them (bone-brain, liver, and aorta). Notably, we discovered that senescent OBs secrete fatty-acid-binding protein 3 to propagate se...
Source: Cell Metabolism - April 4, 2024 Category: Cytology Authors: Wenquan Liang Tiantian Wei Le Hu Meijun Chen Liping Tong Wu Zhou Xingwei Duan Xiaoyang Zhao Weijie Zhou Qing Jiang Guozhi Xiao Weiguo Zou Di Chen Zhipeng Zou Xiaochun Bai Source Type: research
Developing a national nutrition policy strategy to advance cardiometabolic health and health equity
Cell Metab. 2024 Apr 2;36(4):651-654. doi: 10.1016/j.cmet.2024.02.001.NO ABSTRACTPMID:38569468 | DOI:10.1016/j.cmet.2024.02.001 (Source: Cell Metabolism)
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Dariush Mozaffarian Emily A Callahan Dan Glickman Melissa Maitin-Shepard Source Type: research
Our extended microbiome: The human-relevant metabolites and biology of fermented foods
Cell Metab. 2024 Apr 2;36(4):684-701. doi: 10.1016/j.cmet.2024.03.007.ABSTRACTOne of the key modes of microbial metabolism occurring in the gut microbiome is fermentation. This energy-yielding process transforms common macromolecules like polysaccharides and amino acids into a wide variety of chemicals, many of which are relevant to microbe-microbe and microbe-host interactions. Analogous transformations occur during the production of fermented foods, resulting in an abundance of bioactive metabolites. In foods, the products of fermentation can influence food safety and preservation, nutrient availability, and palatability...
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Elisa B Caffrey Justin L Sonnenburg Suzanne Devkota Source Type: research
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals
Cell Metab. 2024 Apr 2;36(4):725-744. doi: 10.1016/j.cmet.2024.03.004.ABSTRACTPostbiotics, which comprise inanimate microorganisms or their constituents, have recently gained significant attention for their potential health benefits. Extensive research on postbiotics has uncovered many beneficial effects on hosts, including antioxidant activity, immunomodulatory effects, gut microbiota modulation, and enhancement of epithelial barrier function. Although these features resemble those of probiotics, the stability and safety of postbiotics make them an appealing alternative. In this review, we provide a comprehensive summary ...
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Xinjie Zhao Shuai Liu Sumin Li Wen Jiang Jingjun Wang Jianxin Xiao Tianyu Chen Jiaying Ma Muhammad Zahoor Khan Wei Wang Mengmeng Li Shengli Li Zhijun Cao Source Type: research
Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity
This study was registered at ClinicalTrials.gov (NCT02706262).PMID:38569471 | DOI:10.1016/j.cmet.2024.03.002 (Source: Cell Metabolism)
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Max C Petersen Gordon I Smith Hector H Palacios Sarah S Farabi Mihoko Yoshino Jun Yoshino Kevin Cho Victor G Davila-Roman Mahalakshmi Shankaran Ruteja A Barve Jinsheng Yu Jennifer H Stern Bruce W Patterson Marc K Hellerstein Gerald I Shulman Gary J Patti Source Type: research
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
Cell Metab. 2024 Apr 2;36(4):857-876.e10. doi: 10.1016/j.cmet.2024.02.007.ABSTRACTLeptin resistance during excess weight gain significantly contributes to the recidivism of obesity to leptin-based pharmacological therapies. The mechanisms underlying the inhibition of leptin receptor (LepR) signaling during obesity are still elusive. Here, we report that histone deacetylase 6 (HDAC6) interacts with LepR, reducing the latter's activity, and that pharmacological inhibition of HDAC6 activity disrupts this interaction and augments leptin signaling. Treatment of diet-induced obese mice with blood-brain barrier (BBB)-permeable HD...
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Dongxian Guan Yuqin Men Alexander Bartlett Mario Andr és Salazar Hernández Jie Xu Xinchi Yi Hu-Song Li Dong Kong Ralph Mazitschek Umut Ozcan Source Type: research
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis
Cell Metab. 2024 Mar 28:S1550-4131(24)00084-6. doi: 10.1016/j.cmet.2024.03.005. Online ahead of print.ABSTRACTActivating Nrf2 by small molecules is a promising strategy to treat postmenopausal osteoporosis. However, there is currently no Nrf2 activator approved for treating chronic diseases, and the downstream mechanism underlying the regulation of Nrf2 on osteoclast differentiation remains unclear. Here, we found that bitopertin, a clinical-stage glycine uptake inhibitor, suppresses osteoclast differentiation and ameliorates ovariectomy-induced bone loss by activating Nrf2. Mechanistically, bitopertin interacts with the K...
Source: Cell Metabolism - April 3, 2024 Category: Cytology Authors: Yimin Dong Honglei Kang Renpeng Peng Zheming Liu Fuben Liao Shi-An Hu Weizhong Ding Pengju Wang Pengchao Yang Meipeng Zhu Sibo Wang Minglong Wu Dawei Ye Xin Gan Feng Li Kehan Song Source Type: research
Futile cycles: Emerging utility from apparent futility
Cell Metab. 2024 Mar 27:S1550-4131(24)00087-1. doi: 10.1016/j.cmet.2024.03.008. Online ahead of print.ABSTRACTFutile cycles are biological phenomena where two opposing biochemical reactions run simultaneously, resulting in a net energy loss without appreciable productivity. Such a state was presumed to be a biological aberration and thus deemed an energy-wasting "futile" cycle. However, multiple pieces of evidence suggest that biological utilities emerge from futile cycles. A few established functions of futile cycles are to control metabolic sensitivity, modulate energy homeostasis, and drive adaptive thermogenesis. Yet, ...
Source: Cell Metabolism - April 2, 2024 Category: Cytology Authors: Anand Kumar Sharma Radhika Khandelwal Christian Wolfrum Source Type: research
Futile cycles: Emerging utility from apparent futility
Cell Metab. 2024 Mar 27:S1550-4131(24)00087-1. doi: 10.1016/j.cmet.2024.03.008. Online ahead of print.ABSTRACTFutile cycles are biological phenomena where two opposing biochemical reactions run simultaneously, resulting in a net energy loss without appreciable productivity. Such a state was presumed to be a biological aberration and thus deemed an energy-wasting "futile" cycle. However, multiple pieces of evidence suggest that biological utilities emerge from futile cycles. A few established functions of futile cycles are to control metabolic sensitivity, modulate energy homeostasis, and drive adaptive thermogenesis. Yet, ...
Source: Cell Metabolism - April 2, 2024 Category: Cytology Authors: Anand Kumar Sharma Radhika Khandelwal Christian Wolfrum Source Type: research
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity
Cell Metab. 2024 Mar 23:S1550-4131(24)00082-2. doi: 10.1016/j.cmet.2024.03.003. Online ahead of print.ABSTRACTMetabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse MAFLD. Hyperinsulinemia promoted TKT expression through the insulin receptor-CCAAT/enhancer-binding protein alpha axis. Utilizing liver-specific TKT overexpression and knockout mouse models, we demonstrated that TKT was s...
Source: Cell Metabolism - March 28, 2024 Category: Cytology Authors: Lingfeng Tong Zhangbing Chen Yangyang Li Xinxia Wang Changjie Yang Yakui Li Yemin Zhu Ying Lu Qi Liu Nannan Xu Sijia Shao Lifang Wu Ping Zhang Guangyu Wu Xiaoyu Wu Xiaosong Chen Junwei Fang Renbing Jia Tianle Xu Bin Li Liang Zheng Junling Liu Xuemei Tong Source Type: research
