Cardiovascular-kidney-metabolic syndrome: A step toward multidisciplinary and inclusive care
Cell Metab. 2023 Dec 5;35(12):2104-2106. doi: 10.1016/j.cmet.2023.10.015.ABSTRACTIn a recent Presidential Advisory report, the American Heart Association (AHA) defined cardiovascular-kidney-metabolic (CKM) syndrome as a spectrum of pathology associated with dysfunctional or excess adiposity and leading to adverse cardiovascular outcomes. Implementing the guidelines set forth by the AHA has the potential to improve population-wide CKM health.PMID:38056429 | DOI:10.1016/j.cmet.2023.10.015 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Sophie E Claudel Ashish Verma Source Type: research
GDF15 is a major determinant of ketogenic diet-induced weight loss
Cell Metab. 2023 Dec 5;35(12):2165-2182.e7. doi: 10.1016/j.cmet.2023.11.003.ABSTRACTA ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying mechanism remains elusive. Here we show that KD reduces energy intake and body weight in humans, pigs, and mice, accompanied by elevated circulating growth differentiation factor 15 (GDF15). In GDF15- or its receptor GFRAL-deficient mice, these effects of KD disappeared, demonstrating an essential role of GDF15-GFRAL signaling in KD-mediated weight loss. Gdf15 mRNA level increases in hepatocytes upon KD feeding, and knockdown of Gdf15 by AAV8 abrogated...
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Jun Feng Lu Meng Qing Zhu Bo Xia Na Na Zhang Xiao Peng Liu Huan Liu Rui Xin Zhang Jun Ying Xiao Hui Yang Ying Qi Zhang Xiao Miao Li Jiang Wei Wu Source Type: research
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
Cell Metab. 2023 Dec 5;35(12):2231-2249.e7. doi: 10.1016/j.cmet.2023.10.018.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) is a leading risk factor for liver cirrhosis and hepatocellular carcinoma. Here, we report that CHRNA4, a subunit of nicotinic acetylcholine receptors (nAChRs), is an accelerator of MASH progression. CHRNA4 also mediates the MASH-promotive effects induced by smoking. Chrna4 was expressed specifically in hepatocytes and exhibited increased levels in mice and patients with MASH. Elevated CHRNA4 levels were positively correlated with MASH severity. We further revealed that during MASH dev...
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Chuyue Pan Jun Liu Yingsheng Gao Maohui Yang Haiyang Hu Chang Liu Minyi Qian Hai-Yang Yuan Song Yang Ming-Hua Zheng Lirui Wang Source Type: research
Fructose sweetens the adipocyte-T cell alliance against tumors
Cell Metab. 2023 Dec 5;35(12):2093-2094. doi: 10.1016/j.cmet.2023.11.004.ABSTRACTDietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8+ T cells for improved tumor control.PMID:38056424 | DOI:10.1016/j.cmet.2023.11.004 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Peipei Zhou Hongbo Chi Source Type: research
All hands on deck: Adipocytes lept-in to drive nerve regeneration
Cell Metab. 2023 Dec 5;35(12):2095-2096. doi: 10.1016/j.cmet.2023.11.007.ABSTRACTThe glial metabolic state instructs nerve regeneration. In this issue of Cell Metabolism, Sundaram, Schütza, Schröter, et al. demonstrate that nerve injury induces adipocytes-glia signaling via leptin, thereby modulating glial metabolism and driving nerve regeneration.PMID:38056425 | DOI:10.1016/j.cmet.2023.11.007 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Alina Rashid Qin Wang Yuanquan Song Source Type: research
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination
Cell Metab. 2023 Dec 5;35(12):2097-2099. doi: 10.1016/j.cmet.2023.11.006.ABSTRACTNutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs by GCN2/FBXO22 inactivates mTOR complex 1 (mTORC1) via mTOR ubiquitination.PMID:38056426 | DOI:10.1016/j.cmet.2023.11.006 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Estela Jacinto Source Type: research
Early-life microbiota as a baby metabolic guardian
Cell Metab. 2023 Dec 5;35(12):2099-2100. doi: 10.1016/j.cmet.2023.11.008.ABSTRACTEarly-life microbiota have a crucial role in healthy development. Antibiotics, on the other hand, can disrupt this beneficial interaction and have been linked to increased adiposity in children. Shelton and collaborators went deeper into the mechanism by which microbiota protect against lipid metabolic dysfunction and diet-induced obesity. The results highlight the long-term metabolic risk of early antibiotic exposure.PMID:38056427 | DOI:10.1016/j.cmet.2023.11.008 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Max Nieuwdorp Melany Rios-Morales Source Type: research
Redox and detox: Malate shuttle metabolism keeps exhausted T cells fit
Cell Metab. 2023 Dec 5;35(12):2101-2103. doi: 10.1016/j.cmet.2023.11.005.ABSTRACTThe malate shuttle is known to maintain the balance of NAD+/NADH between the cytosol and mitochondria. However, in Tex cells, it primarily detoxifies ammonia (via GOT1-mediated production of 2-KG in an atypical reaction) and provides longevity to chronic-infection-induced Tex cells against ammonia-induced cell death.PMID:38056428 | DOI:10.1016/j.cmet.2023.11.005 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Alok Kumar Greg M Delgoffe Source Type: research
Cardiovascular-kidney-metabolic syndrome: A step toward multidisciplinary and inclusive care
Cell Metab. 2023 Dec 5;35(12):2104-2106. doi: 10.1016/j.cmet.2023.10.015.ABSTRACTIn a recent Presidential Advisory report, the American Heart Association (AHA) defined cardiovascular-kidney-metabolic (CKM) syndrome as a spectrum of pathology associated with dysfunctional or excess adiposity and leading to adverse cardiovascular outcomes. Implementing the guidelines set forth by the AHA has the potential to improve population-wide CKM health.PMID:38056429 | DOI:10.1016/j.cmet.2023.10.015 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Sophie E Claudel Ashish Verma Source Type: research
GDF15 is a major determinant of ketogenic diet-induced weight loss
Cell Metab. 2023 Dec 5;35(12):2165-2182.e7. doi: 10.1016/j.cmet.2023.11.003.ABSTRACTA ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying mechanism remains elusive. Here we show that KD reduces energy intake and body weight in humans, pigs, and mice, accompanied by elevated circulating growth differentiation factor 15 (GDF15). In GDF15- or its receptor GFRAL-deficient mice, these effects of KD disappeared, demonstrating an essential role of GDF15-GFRAL signaling in KD-mediated weight loss. Gdf15 mRNA level increases in hepatocytes upon KD feeding, and knockdown of Gdf15 by AAV8 abrogated...
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Jun Feng Lu Meng Qing Zhu Bo Xia Na Na Zhang Xiao Peng Liu Huan Liu Rui Xin Zhang Jun Ying Xiao Hui Yang Ying Qi Zhang Xiao Miao Li Jiang Wei Wu Source Type: research
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
Cell Metab. 2023 Dec 5;35(12):2231-2249.e7. doi: 10.1016/j.cmet.2023.10.018.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) is a leading risk factor for liver cirrhosis and hepatocellular carcinoma. Here, we report that CHRNA4, a subunit of nicotinic acetylcholine receptors (nAChRs), is an accelerator of MASH progression. CHRNA4 also mediates the MASH-promotive effects induced by smoking. Chrna4 was expressed specifically in hepatocytes and exhibited increased levels in mice and patients with MASH. Elevated CHRNA4 levels were positively correlated with MASH severity. We further revealed that during MASH dev...
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Chuyue Pan Jun Liu Yingsheng Gao Maohui Yang Haiyang Hu Chang Liu Minyi Qian Hai-Yang Yuan Song Yang Ming-Hua Zheng Lirui Wang Source Type: research
Fructose sweetens the adipocyte-T cell alliance against tumors
Cell Metab. 2023 Dec 5;35(12):2093-2094. doi: 10.1016/j.cmet.2023.11.004.ABSTRACTDietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8+ T cells for improved tumor control.PMID:38056424 | DOI:10.1016/j.cmet.2023.11.004 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Peipei Zhou Hongbo Chi Source Type: research
All hands on deck: Adipocytes lept-in to drive nerve regeneration
Cell Metab. 2023 Dec 5;35(12):2095-2096. doi: 10.1016/j.cmet.2023.11.007.ABSTRACTThe glial metabolic state instructs nerve regeneration. In this issue of Cell Metabolism, Sundaram, Schütza, Schröter, et al. demonstrate that nerve injury induces adipocytes-glia signaling via leptin, thereby modulating glial metabolism and driving nerve regeneration.PMID:38056425 | DOI:10.1016/j.cmet.2023.11.007 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Alina Rashid Qin Wang Yuanquan Song Source Type: research
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination
Cell Metab. 2023 Dec 5;35(12):2097-2099. doi: 10.1016/j.cmet.2023.11.006.ABSTRACTNutrient availability is conveyed to the mechanistic target of rapamycin (mTOR), which couples metabolic processes with cell growth and proliferation. How mTOR itself is modulated by amino acid levels remains poorly understood. Ge and colleagues now demonstrate that broad sensing of uncharged tRNAs by GCN2/FBXO22 inactivates mTOR complex 1 (mTORC1) via mTOR ubiquitination.PMID:38056426 | DOI:10.1016/j.cmet.2023.11.006 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Estela Jacinto Source Type: research
Early-life microbiota as a baby metabolic guardian
Cell Metab. 2023 Dec 5;35(12):2099-2100. doi: 10.1016/j.cmet.2023.11.008.ABSTRACTEarly-life microbiota have a crucial role in healthy development. Antibiotics, on the other hand, can disrupt this beneficial interaction and have been linked to increased adiposity in children. Shelton and collaborators went deeper into the mechanism by which microbiota protect against lipid metabolic dysfunction and diet-induced obesity. The results highlight the long-term metabolic risk of early antibiotic exposure.PMID:38056427 | DOI:10.1016/j.cmet.2023.11.008 (Source: Cell Metabolism)
Source: Cell Metabolism - December 6, 2023 Category: Cytology Authors: Max Nieuwdorp Melany Rios-Morales Source Type: research
