Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management
Cell Metab. 2024 Feb 20:S1550-4131(24)00048-2. doi: 10.1016/j.cmet.2024.02.002. Online ahead of print.ABSTRACTThe rise of artificial intelligence (AI) has revolutionized various scientific fields, particularly in medicine, where it has enabled the modeling of complex relationships from massive datasets. Initially, AI algorithms focused on improved interpretation of diagnostic studies such as chest X-rays and electrocardiograms in addition to predicting patient outcomes and future disease onset. However, AI has evolved with the introduction of transformer models, allowing analysis of the diverse, multimodal data sources exi...
Source: Cell Metabolism - March 1, 2024 Category: Cytology Authors: Evan D Muse Eric J Topol Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Cell Metab. 2024 Feb 20:S1550-4131(24)00014-7. doi: 10.1016/j.cmet.2024.01.014. Online ahead of print.ABSTRACTThrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with COVID-19 and in patients with MACEs. 2MBC enhances platelet hyperreactivity and thrombus formation in mic...
Source: Cell Metabolism - February 24, 2024 Category: Cytology Authors: Kan Huang Zilun Li Xi He Jun Dai Bingding Huang Yongxia Shi Dongxiao Fan Zefeng Zhang Yunchong Liu Na Li Zhongyu Zhang Jiangyun Peng Chenshu Liu Renli Zeng Zhipeng Cen Tengyao Wang Wenchao Yang Meifeng Cen Jingyu Li Shuai Yuan Lu Zhang Dandan Hu Shuxiang Source Type: research
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
Cell Metab. 2024 Feb 13:S1550-4131(24)00018-4. doi: 10.1016/j.cmet.2024.01.018. Online ahead of print.ABSTRACTHere, we identify a subset of vascular pericytes, defined by expression of platelet-derived growth factor receptor beta (PDGFR-β) and G-protein-coupled receptor 91 (GPR91), that promote tumorigenesis and tyrosine kinase inhibitors (TKIs) resistance by functioning as the primary methionine source for cancer stem cells (CSCs) in clear cell renal cell carcinoma (ccRCC). Tumor-cell-derived succinate binds to GPR91 on pericyte to activate autophagy for methionine production. CSCs use methionine to create stabilizing N6...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: ChuanJie Zhang ZunGuo Du Yi Gao Kiat Shenq Lim WenJie Zhou Hai Huang HongChao He Jun Xiao DanFeng Xu QingQuan Li Source Type: research
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
Cell Metab. 2024 Feb 12:S1550-4131(24)00015-9. doi: 10.1016/j.cmet.2024.01.015. Online ahead of print.ABSTRACTAging is underpinned by pronounced metabolic decline; however, the drivers remain obscure. Here, we report that IgG accumulates during aging, particularly in white adipose tissue (WAT), to impair adipose tissue function and metabolic health. Caloric restriction (CR) decreases IgG accumulation in WAT, whereas replenishing IgG counteracts CR's metabolic benefits. IgG activates macrophages via Ras signaling and consequently induces fibrosis in WAT through the TGF-β/SMAD pathway. Consistently, B cell null mice are pro...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: Lexiang Yu Qianfen Wan Qiongming Liu Yong Fan Qiuzhong Zhou Alicja A Skowronski Summer Wang Zhengping Shao Chen-Yu Liao Lei Ding Brian K Kennedy Shan Zha Jianwen Que Charles A LeDuc Lei Sun Liheng Wang Li Qiang Source Type: research
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
Cell Metab. 2024 Feb 13:S1550-4131(24)00018-4. doi: 10.1016/j.cmet.2024.01.018. Online ahead of print.ABSTRACTHere, we identify a subset of vascular pericytes, defined by expression of platelet-derived growth factor receptor beta (PDGFR-β) and G-protein-coupled receptor 91 (GPR91), that promote tumorigenesis and tyrosine kinase inhibitors (TKIs) resistance by functioning as the primary methionine source for cancer stem cells (CSCs) in clear cell renal cell carcinoma (ccRCC). Tumor-cell-derived succinate binds to GPR91 on pericyte to activate autophagy for methionine production. CSCs use methionine to create stabilizing N6...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: ChuanJie Zhang ZunGuo Du Yi Gao Kiat Shenq Lim WenJie Zhou Hai Huang HongChao He Jun Xiao DanFeng Xu QingQuan Li Source Type: research
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
Cell Metab. 2024 Feb 12:S1550-4131(24)00015-9. doi: 10.1016/j.cmet.2024.01.015. Online ahead of print.ABSTRACTAging is underpinned by pronounced metabolic decline; however, the drivers remain obscure. Here, we report that IgG accumulates during aging, particularly in white adipose tissue (WAT), to impair adipose tissue function and metabolic health. Caloric restriction (CR) decreases IgG accumulation in WAT, whereas replenishing IgG counteracts CR's metabolic benefits. IgG activates macrophages via Ras signaling and consequently induces fibrosis in WAT through the TGF-β/SMAD pathway. Consistently, B cell null mice are pro...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: Lexiang Yu Qianfen Wan Qiongming Liu Yong Fan Qiuzhong Zhou Alicja A Skowronski Summer Wang Zhengping Shao Chen-Yu Liao Lei Ding Brian K Kennedy Shan Zha Jianwen Que Charles A LeDuc Lei Sun Liheng Wang Li Qiang Source Type: research
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
Cell Metab. 2024 Feb 13:S1550-4131(24)00018-4. doi: 10.1016/j.cmet.2024.01.018. Online ahead of print.ABSTRACTHere, we identify a subset of vascular pericytes, defined by expression of platelet-derived growth factor receptor beta (PDGFR-β) and G-protein-coupled receptor 91 (GPR91), that promote tumorigenesis and tyrosine kinase inhibitors (TKIs) resistance by functioning as the primary methionine source for cancer stem cells (CSCs) in clear cell renal cell carcinoma (ccRCC). Tumor-cell-derived succinate binds to GPR91 on pericyte to activate autophagy for methionine production. CSCs use methionine to create stabilizing N6...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: ChuanJie Zhang ZunGuo Du Yi Gao Kiat Shenq Lim WenJie Zhou Hai Huang HongChao He Jun Xiao DanFeng Xu QingQuan Li Source Type: research
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
Cell Metab. 2024 Feb 12:S1550-4131(24)00015-9. doi: 10.1016/j.cmet.2024.01.015. Online ahead of print.ABSTRACTAging is underpinned by pronounced metabolic decline; however, the drivers remain obscure. Here, we report that IgG accumulates during aging, particularly in white adipose tissue (WAT), to impair adipose tissue function and metabolic health. Caloric restriction (CR) decreases IgG accumulation in WAT, whereas replenishing IgG counteracts CR's metabolic benefits. IgG activates macrophages via Ras signaling and consequently induces fibrosis in WAT through the TGF-β/SMAD pathway. Consistently, B cell null mice are pro...
Source: Cell Metabolism - February 20, 2024 Category: Cytology Authors: Lexiang Yu Qianfen Wan Qiongming Liu Yong Fan Qiuzhong Zhou Alicja A Skowronski Summer Wang Zhengping Shao Chen-Yu Liao Lei Ding Brian K Kennedy Shan Zha Jianwen Que Charles A LeDuc Lei Sun Liheng Wang Li Qiang Source Type: research
Sphingolipid metabolism controls mammalian heart regeneration
Cell Metab. 2024 Feb 7:S1550-4131(24)00017-2. doi: 10.1016/j.cmet.2024.01.017. Online ahead of print.ABSTRACTUtilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision, proper management of lipid composition is crucial for cellular and organismal health, but its role in heart regeneration remains unclear. Here, we demonstrate widespread sphingolipid metabolism remodeling in neonatal hearts after injury and find that SphK1 and SphK2, isoenzymes producing the same sphingolipid metabolite sphingosine-1-phosph...
Source: Cell Metabolism - February 17, 2024 Category: Cytology Authors: Xiaoqian Ji Zihao Chen Qiyuan Wang Bin Li Yan Wei Yun Li Jianqing Lin Weisheng Cheng Yijie Guo Shilin Wu Longkun Mao Yuzhou Xiang Tian Lan Shanshan Gu Meng Wei Joe Z Zhang Lan Jiang Jia Wang Jin Xu Nan Cao Source Type: research
Sphingolipid metabolism controls mammalian heart regeneration
Cell Metab. 2024 Feb 7:S1550-4131(24)00017-2. doi: 10.1016/j.cmet.2024.01.017. Online ahead of print.ABSTRACTUtilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision, proper management of lipid composition is crucial for cellular and organismal health, but its role in heart regeneration remains unclear. Here, we demonstrate widespread sphingolipid metabolism remodeling in neonatal hearts after injury and find that SphK1 and SphK2, isoenzymes producing the same sphingolipid metabolite sphingosine-1-phosph...
Source: Cell Metabolism - February 17, 2024 Category: Cytology Authors: Xiaoqian Ji Zihao Chen Qiyuan Wang Bin Li Yan Wei Yun Li Jianqing Lin Weisheng Cheng Yijie Guo Shilin Wu Longkun Mao Yuzhou Xiang Tian Lan Shanshan Gu Meng Wei Joe Z Zhang Lan Jiang Jia Wang Jin Xu Nan Cao Source Type: research