Reductive cell death: the other side of the coin
Cancer Gene Therapy, Published online: 04 April 2023; doi:10.1038/s41417-023-00612-3The balance between oxidants and antioxidants within cells, known as redox homeostasis, is crucial for proper cellular function. Disruption of redox homeostasis has been implicated in the development and treatment of various human diseases, including cancer. Regulated cell death, a fundamental biological process, occurs in various forms and functions, often caused by oxidative stress damaging macromolecules (such as DNA, lipids, and proteins). Surprisingly, recent studies have suggested that aberrant reductive stress can also trigger regula...
Source: Cancer Gene Therapy - April 4, 2023 Category: Cancer & Oncology Authors: Ruoxi Zhang Rui Kang Daolin Tang Source Type: research
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Cancer Gene Therapy, Published online: 28 March 2023; doi:10.1038/s41417-023-00602-5Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 28, 2023 Category: Cancer & Oncology Authors: Ars ène Mékinian Anne Quinquenel Koce ïla Ait Belkacem Feriel Kanoun Elisabetta Dondi Emilie Franck Marouane Boubaya Ma ïssa Mhibik Fanny Baran-Marszak R émi Letestu Florence Ajchenbaum-Cymbalista Vincent L évy Nadine Varin-Blank Christine Le Roy Source Type: research
E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA
Cancer Gene Therapy, Published online: 27 March 2023; doi:10.1038/s41417-023-00607-0E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 27, 2023 Category: Cancer & Oncology Authors: Hao-Ming Shen Di Zhang Ping Xiao Bin Qu Yi-Fan Sun Source Type: research
Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway
Cancer Gene Therapy, Published online: 17 March 2023; doi:10.1038/s41417-023-00604-3Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 17, 2023 Category: Cancer & Oncology Authors: Atsuko Deguchi Miho Watanabe-Takahashi Taishi Mishima Tsutomu Omori Umeharu Ohto Nobuto Arashiki Fumio Nakamura Kiyotaka Nishikawa Yoshiro Maru Source Type: research
Loss of EPS8 sensitizes non-small-cell lung carcinoma to chemotherapy-induced DNA damage
Cancer Gene Therapy, Published online: 17 March 2023; doi:10.1038/s41417-023-00606-1Loss of EPS8 sensitizes non-small-cell lung carcinoma to chemotherapy-induced DNA damage (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 17, 2023 Category: Cancer & Oncology Authors: Yingqi Qiu Binyan Xu Jianhua Feng Chunsheng Wang Yiran Chen Yanjie He Xiaoling Xie Yuhua Li Source Type: research
MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo
Cancer Gene Therapy, Published online: 17 March 2023; doi:10.1038/s41417-023-00605-2MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 17, 2023 Category: Cancer & Oncology Authors: Yichao Liang Di Wu Qiao Qu Zhilong Li Hongzhuan Yin Source Type: research
CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer
Cancer Gene Therapy, Published online: 15 March 2023; doi:10.1038/s41417-023-00603-4CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 15, 2023 Category: Cancer & Oncology Authors: Qiang Yuan Yi Chu Xiaoyu Li Yunshu Shi Yingying Chen Jimin Zhao Jing Lu Kangdong Liu Yaping Guo Source Type: research
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3
Cancer Gene Therapy, Published online: 08 March 2023; doi:10.1038/s41417-023-00591-5Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3 (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 8, 2023 Category: Cancer & Oncology Authors: Wenjing Gong Yang Guo Hang Yuan Rui Chai Ziang Wan Boan Zheng Xinye Hu Bingchen Chen Shan Gao Qiaoqiong Dai Peng Yu Shiliang Tu Source Type: research
Correction to: Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases
Cancer Gene Therapy, Published online: 08 March 2023; doi:10.1038/s41417-023-00601-6Correction to: Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - March 8, 2023 Category: Cancer & Oncology Authors: Darshini Kuruppu Deepak Bhere Christian T. Farrar Khalid Shah Anna-Liisa Brownell Umar Mahmood Kenneth K. Tanabe Source Type: research
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy
Cancer Gene Therapy, Published online: 28 February 2023; doi:10.1038/s41417-023-00597-zViral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 28, 2023 Category: Cancer & Oncology Authors: Seyed Esmaeil Ahmadi Maral Soleymani Fahimeh Shahriyary Mohammad Reza Amirzargar Mahya Ofoghi Mohammad Davood Fattahi Majid Safa Source Type: research
β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma
Cancer Gene Therapy, Published online: 28 February 2023; doi:10.1038/s41417-023-00599-xβ3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 28, 2023 Category: Cancer & Oncology Authors: Gennaro Bruno Nicoletta Nastasi Angela Subbiani Alessia Boaretto Sara Ciullini Mannurita Gianluca Mattei Patrizia Nardini Chiara Della Bella Alberto Magi Alessandro Pini Emanuela De Marco Annalisa Tondo Claudio Favre Maura Calvani Source Type: research
Therapeutic utility of engineered myeloid cells in the tumor microenvironment
Cancer Gene Therapy, Published online: 28 February 2023; doi:10.1038/s41417-023-00600-7Therapeutic utility of engineered myeloid cells in the tumor microenvironment (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 28, 2023 Category: Cancer & Oncology Authors: Alessandro Canella Prajwal Rajappa Source Type: research
Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway
Cancer Gene Therapy, Published online: 28 February 2023; doi:10.1038/s41417-022-00500-2Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 28, 2023 Category: Cancer & Oncology Authors: Qingfeng Ni Hai Zhang Xiaoli Shi Xiangcheng Li Source Type: research
Amplified therapeutic targets in high-grade serous ovarian carcinoma – a review of the literature with quantitative appraisal
Cancer Gene Therapy, Published online: 20 February 2023; doi:10.1038/s41417-023-00589-zAmplified therapeutic targets in high-grade serous ovarian carcinoma – a review of the literature with quantitative appraisal (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 20, 2023 Category: Cancer & Oncology Authors: Thomas Talbot Haonan Lu Eric O. Aboagye Source Type: research
Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction
Cancer Gene Therapy, Published online: 17 February 2023; doi:10.1038/s41417-023-00598-ySuppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - February 17, 2023 Category: Cancer & Oncology Authors: Byungjoo Kim Jihye Gwak Minjoong Kim Seungyeon Yang Sunsook Hwang Seungmin Shin Ji Hye Kim Jaekyoung Son Seung Min Jeong Source Type: research
