COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
Conclusions: Macrophage efferocytosis of eosinophils is impaired in COPD and is related to the severity and frequency of COPD exacerbations. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 9, 2014 Category: Respiratory Medicine Authors: Osama EltboliMona BafadhelFay HollinsAdam WrightBeverley HargadonNeeta KulkarniChristopher Brightling Source Type: research

Efficacy and safety of fluticasone furoate 100 mug and 200 mug once daily in the treatment of moderate-severe asthma in adults and adolescents: a 24-week randomised study
This study was performed to descriptively assess the efficacy and safety of two doses of FF, with no planned formal statistical hypothesis testing. Methods: This was a 24-week double-blind, multicentre, parallel-group study (NCT01431950). Patients aged>=12 years with moderate-severe persistent asthma and uncontrolled on mid-high dose ICS were stratified by baseline FEV1 and randomised (1:1) to treatment with FF 100mug or 200mug once daily in the evening. The primary endpoint was change from baseline trough FEV1 after 24 weeks; secondary and other endpoints included peak expiratory flow (PEF) and rescue- and symptom-free...
Source: BMC Pulmonary Medicine - Latest articles - July 9, 2014 Category: Respiratory Medicine Authors: Ashley WoodcockJan LötvallWilliam BusseEric BatemanSally StoneAnna EllsworthLoretta Jacques Source Type: research

Comprehensive multiplexed protein quantitation delineates eosinophilic and neutrophilic experimental asthma
Conclusion: Our data suggest that the commercial markers we are currently relying on to diagnose asthma subtypes are not giving us comprehensive or specific enough information. The analysed protein profiles allowed to discriminate the two models and may add useful information for characterization of different asthma phenotypes. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 4, 2014 Category: Respiratory Medicine Authors: Maria BergquistSofia JonassonJosephine HjobergGöran HedenstiernaJörg Hanrieder Source Type: research

The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods
DiscussionThe COCOA study will improve our understanding of how individual genetic or environmental risk factors influence susceptibility to allergic disease and how these variables interact to shape the phenotype of allergic diseases. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 3, 2014 Category: Respiratory Medicine Authors: Hyeon-Jong YangSo-Yeon LeeDong In SuhYoun ShinByoung-Ju KimJu-Hee SeoHyoung ChangKyung KimKangmo AhnYee-Jin ShinKyung-Sook LeeCheol LeeSe-Young OhHo KimJong-Han LeemHwan KimEun-Jin KimJoo-Shil LeeSoo-Jong Hong Source Type: research

Effects of sex hormones on bronchial reactivity during the menstrual cycle
Conclusions: In conclusion, our data show that PC20FEV1.0 was decreased in the follicular phase of the menstrual cycle in about 30% of women and was associated with lower cAMP levels in sputum samples, which may contribute to bronchoconstriction. Our results also suggest a link between PMA and testosterone levels. However, whether these findings are of clinical significance in terms of the management of asthma or asthma worsening during the menstrual cycle needs further investigation. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 1, 2014 Category: Respiratory Medicine Authors: Maria MatteisFrancesca PolverinoGiuseppe SpazianoFiorentina RoviezzoCarlo SantorielloNikol SulloMaria BucciFrancesco RossiMario PolverinoCaroline OwenBruno D¿Agostino Source Type: research

Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients `on¿ or `off¿ augmentation therapy
Background: There is still limited information on systemic inflammation in alpha-1-antitrypsin-deficient (AATD) COPD patients and what effect alpha-1-antitrypsin augmentation therapy and/or exercise might have on circulating inflammatory cytokines. We hypothesized that AATD COPD patients on augmentation therapy (AATD + AUG) would have lower circulating and skeletal muscle inflammatory cytokines compared to AATD COPD patients not receiving augmentation therapy (AATD-AUG) and/or the typical non-AATD (COPD) patient. We also hypothesized that cytokine response to exercise would be lower in AATD + AU...
Source: BMC Pulmonary Medicine - Latest articles - June 30, 2014 Category: Respiratory Medicine Authors: I OlfertMoh MalekTomas EaganHarrieth WagnerPeter Wagner Source Type: research

Efficacy and safety of moxifloxacin in community acquired pneumonia: a prospective, multicenter, observational study (CAPRIVI)
Background: Community acquired pneumonia (CAP) is a major cause of morbidity, hospitalization, and mortality worldwide. Management of CAP for many patients requires rapid initiation of empirical antibiotic treatment, based on the spectrum of activity of available antimicrobial agents and evidence on local antibiotic resistance. Few data exist on the severity profile and treatment of hospitalized CAP patients in Eastern and Central Europe and the Middle East, in particular on use of moxifloxacin (Avelox(R)), which is approved in these regions. Methods: CAPRIVI (Community Acquired Pneumonia: tReatment wIth AVelox(R) in hospI...
Source: BMC Pulmonary Medicine - Latest articles - June 30, 2014 Category: Respiratory Medicine Authors: Ilija KuzmanAlexandr BezlepkoIrena Kondova TopuzovskaLászló RókuszLiudmyla IudinaHans-Peter MarschallThomas Petri Source Type: research

Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy
Background: There is still limited information on systemic inflammation in alpha-1-antitrypsin-deficient (AATD) COPD patients and what effect alpha-1-antitrypsin augmentation therapy and/or exercise might have on circulating inflammatory cytokines. We hypothesized that AATD COPD patients on augmentation therapy (AATD + AUG) would have lower circulating and skeletal muscle inflammatory cytokines compared to AATD COPD patients not receiving augmentation therapy (AATD-AUG) and/or the typical non-AATD (COPD) patient. We also hypothesized that cytokine response to exercise would be lower in AATD + AUG compared to AATD-AUG or CO...
Source: BMC Pulmonary Medicine - Latest articles - June 30, 2014 Category: Respiratory Medicine Authors: Mark OlfertMoh MalekTomas EaganHarrieth WagnerPeter Wagner Source Type: research

An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features
Conclusions: TWCLs were only observed in the CPFE patients. They were classified as lesions with coexistent fibrosing interstitial pneumonia and emphysema, and should be considered an important pathological and radiological feature of CPFE. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - June 28, 2014 Category: Respiratory Medicine Authors: Minoru InomataSoichiro IkushimaNobuyasu AwanoKeisuke KondohKohta SatakeMasahiro MasuoYuji KusunokiAtsuko MoriyaHiroyuki KamiyaTsunehiro AndoNoriyo YanagawaToshio KumasakaTakashi OguraFumikazu SakaiArata AzumaAkihiko GemmaTamiko Takemura Source Type: research

Pseudomonas aeruginosa isolates in severe chronic obstructive pulmonary disease: characterization and risk factors
Conclusions: The main risk factors for P. aeruginosa isolation in severe COPD were the extent of bronchiectasis and exposure to antibiotics. Over 10% of these patients fulfilled criteria for chronic colonization by P. aeruginosa and showed clonal persistence, independently of the presence of bronchiectasis. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - June 26, 2014 Category: Respiratory Medicine Authors: Miguel GallegoXavier PomaresMateu EspasaEva CastañerMar SoléDavid SuárezEduard MonsóConcepción Montón Source Type: research

Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD
Background: Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients. Methods: Using both generic (15D) and respiratory-specific (AQ20) instruments, HRQoL was assessed in a hospital based COPD population (N = 739, 64% males, mean age 64 years, SD 7 years) in this observational study with inferential analysis. The prevalence of their co-morbidities was compared with those of 5000 population controls. The patients represented all severity stages of COPD and the patterns of common concomitant d...
Source: BMC Pulmonary Medicine - Latest articles - June 19, 2014 Category: Respiratory Medicine Authors: Jukka KoskelaMaritta KilpeläinenHenna KupiainenWitold MazurHarri SintonenMarike BoezenAri LindqvistDirkje PostmaTarja Laitinen Source Type: research

Pattern of respiratory diseases in children presenting to the paediatric emergency unit of the University of Nigeria Teaching Hospital, Enugu: a case series report
Background: Respiratory diseases are one of the causes of childhood morbidity and mortality as well as hospitalization globally. The patterns of different respiratory illnesses in several parts of the world have been reported but there are few on the combined burden of the diseases. Determination of the burden of respiratory diseases as a group will help ascertain their collective impact on the health systems in order to develop intervention measures. Methods: Data from case notes of children with respiratory diseases admitted to the University of Nigeria Teaching Hospital Enugu, Nigeria over a six year period were extract...
Source: BMC Pulmonary Medicine - Latest articles - June 10, 2014 Category: Respiratory Medicine Authors: Oguonu TagboAyuk ChikaodinakaEdelu OnyekaNdu Kingsley Source Type: research

Flagellin concentrations in expectorations from cystic fibrosis patients
Conclusions: This is the first demonstration that flagellin is present in the sputum of patients. Thus, attempts to down regulate inflammation by the use of TLR5 (flagellin receptor) antagonists remain a possibility. However, this result needs to be extended to a larger number of patients to validate it for future research on this subject. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - June 9, 2014 Category: Respiratory Medicine Authors: Viviane BalloyGuiti ThévenotThierry BienvenuPhilippe MorandHarriet CorvolAnnick ClementReuben RamphalDominique HubertMichel Chignard Source Type: research

Cerebrovascular responses to submaximal exercise in women with COPD
Background: COPD patients have decreased physical fitness, and have an increased risk of vascular disease. In the general population, fitness is positively associated with resting cerebral blood flow velocity, however, little is known about the cerebrovascular response during exercise particularly in COPD patients. We hypothesized that COPD patients would have lower cerebral blood flow during exercise secondary to decreased physical fitness and underlying vascular disease. Methods: Cardiopulmonary exercise testing was conducted in 11 women with GOLD stage I-II COPD, and 11 healthy controls to assess fitness. Cerebro- and c...
Source: BMC Pulmonary Medicine - Latest articles - June 5, 2014 Category: Respiratory Medicine Authors: Sara HartmannRichard LeighMarc Poulin Source Type: research

Maximal exercise in obese patients with COPD: the role of fat free mass
Background: Obese patients (OB) with COPD may better tolerate exercise as compared to normal weight (NW) COPD patients, even if the reason for this is not yet fully understood. We investigated the interactions between obesity, lung hyperinflation, fat-free mass (FFM) and exercise capacity in COPD. Methods: Forty-four patients (16 females; age 65 ± 8 yrs) were assessed by resting lung function and body composition and exercised on a cycle-ergometer to exhaustion. Results: Twenty-two OB and 22 NW patients did not differ in age, gender and airflow obstruction degree, but in FFM (p  (Source: BM...
Source: BMC Pulmonary Medicine - Latest articles - May 30, 2014 Category: Respiratory Medicine Authors: Marina AielloElisabetta TeopompiPanagiota TzaniSara RamponiMaria GioiaEmilio MarangioAlfredo Chetta Source Type: research

Maximal Exercise in Obese Patients with COPD. The role of Fat Free Mass
Background: Obese patients (OB) with COPD may better tolerate exercise as compared to normal weight (NW) COPD patients, even if the reason of this fact is not completely understood. We investigated the interactions between obesity, lung hyperinflation, fat-free mass (FMM) and exercise capacity in COPD.MethodS: Forty-four patients (16 females; age 65 +/- 8 yrs) were assessed by resting lung function and body composition and exercised on a cycle-ergometer to exhaustion. Results: : Twenty-two OB and 22 NW patients did not differ in age, gender and airflow obstruction degree, but in FFM (p
Source: BMC Pulmonary Medicine - Latest articles - May 30, 2014 Category: Respiratory Medicine Authors: Marina AielloElisabetta TeopompiPanagiota TzaniSara RamponiMaria GioiaEmilio MarangioAlfredo Chetta Source Type: research

Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia
Conclusions: Together, these findings indicate that ATM plays a key role in inflammatory response after airway mucosal injury. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 29, 2014 Category: Respiratory Medicine Authors: Olaf EickmeierSu KimEva HerrmannConstanze DöringRuth DueckerSandra VossSibylle WehnerChristoph HölscherJulia PietznerStefan ZielenRalf Schubert Source Type: research

Upregulation of the tight junction protein occludin: effects on ventilation-induced lung injury and mechanisms of action
Conclusion: Mechanical ventilation can activate the PKC signaling pathway and tight junction proteins participate in this pathway. Up-regulation of occludin can reduce ventilation-induced lung injury. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 29, 2014 Category: Respiratory Medicine Authors: Mengjie LiuChangping GuYuelan Wang Source Type: research

Quantitative analysis of lung elastic fibers in idiopathic pleuroparenchymal fibroelastosis (IPPFE): comparison of clinical, radiological, and pathological findings with those of idiopathic pulmonary fibrosis (IPF)
Background: The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary fibrosis (IPF). The amount of elastic fibers (EF) and detailed differences between IPPFE and IPF have not been fully elucidated. The aim of this study was to quantify the EF and identify the differences between IPPFE and IPF. Methods: We evaluated six patients with IPPFE and 28 patients with IPF who underwent surgical lung biopsy or autopsy. The patients' clinical history, physical findings, chest high-re...
Source: BMC Pulmonary Medicine - Latest articles - May 28, 2014 Category: Respiratory Medicine Authors: Noriyuki EnomotoHideki KusagayaYoshiyuki OyamaMasato KonoYusuke KaidaShigeki KuroishiDai HashimotoTomoyuki FujisawaKoshi YokomuraNaoki InuiYutaro NakamuraTakafumi Suda Source Type: research

Disease knowledge level is a noteworthy risk factor of anxiety and depression in patients with chronic obstructive pulmonary disease: a cross-sectional study
Background: Risk factors of anxiety and depression symptoms in patients with chronic obstructive pulmonary disease (COPD) have been widely researched, but most of them cannot be addressed clinically. The aim of this study was to investigate whether COPD knowledge level is a risk factor of anxiety and/or depression in COPD patients in addition to functional capacity and quality of life, and to determine the key topics of COPD knowledge. Methods: A total of 364 COPD patients from four centers were recruited into this cross-sectional survey. Subjects' general medical information, assessments of lung function, dyspnea, quality...
Source: BMC Pulmonary Medicine - Latest articles - May 28, 2014 Category: Respiratory Medicine Authors: Qiao ZhangJiangrong LiaoXiuqing LiaoXiuling WuMin WanChangzheng WangQianli Ma Source Type: research

Pulmonary function in patients with Huntington¿s Disease
Background: Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric disturbances. Chest muscle rigidity, respiratory muscle weakness, difficulty in clearing airway secretions and swallowing abnormalities have been described in patients with neurodegenerative disorders including HD. However limited information is available regarding respiratory function in HD patients. The purpose of this study was to investigate pulmonary function of patients with HD in comparison to healthy volunteers, and its association with motor severity. Methods: Pulmonary function measu...
Source: BMC Pulmonary Medicine - Latest articles - May 26, 2014 Category: Respiratory Medicine Authors: Alvaro ReyesTravis CruickshankMel ZimanKazunori Nosaka Source Type: research

Similar matrix alterations in alveolar and small airway walls of COPD patients
Conclusions: In conclusion, remodelling in the alveolar and small airway wall in COPD is markedly similar and already present in moderate COPD. Notably, alveolar collagen and a remodelling index relate to lung function. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 26, 2014 Category: Respiratory Medicine Authors: Irene EurlingsMieke DentenerJack CleutjensCarine PeutzGernot RohdeEmiel WoutersNiki Reynaert Source Type: research

Pulmonary function in patients with Huntington's Disease
Background: Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric disturbances. Chest muscle rigidity, respiratory muscle weakness, difficulty in clearing airway secretions and swallowing abnormalities have been described in patients with neurodegenerative disorders including HD. However limited information is available regarding respiratory function in HD patients. The purpose of this study was to investigate pulmonary function of patients with HD in comparison to healthy volunteers, and its association with motor severity. Methods: Pulmonary function measu...
Source: BMC Pulmonary Medicine - Latest articles - May 26, 2014 Category: Respiratory Medicine Authors: Alvaro ReyesTravis CruickshankMel ZimanKazunori Nosaka Source Type: research

The PROTECCT-M study: a cohort study investigating associations between novel specific biomarkers, patient-related, healthcare system markers and the trajectory of COPD patients treated in primary care
This study aims to provide evidence of determinants of a COPD trajectory, including novel specific biomarkers and other patient- and healthcare system-related markers.Trial registration: ClinicalTrials.gov Protocol Registration System, Identifier: NCT01698151 (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 20, 2014 Category: Respiratory Medicine Authors: Jens SøndergaardAnders Halling Source Type: research

Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia - short term evaluation of safety and tolerability
Conclusions: Treatment with lecithinized superoxide dismutase is safe and improves the levels of serum markers such as lactate dehydrogenase and surfactant protein-A in patients with advanced idiopathic interstitial pneumonias with severe respiratory dysfunction. Considering the results of the current study, further investigations into the effects and treatment potential of long-term administration of lecithinized superoxide dismutase may be warranted.Trial registration: University hospital Medical Information Network (UMIN) clinical trials registry no. 000000752 (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 17, 2014 Category: Respiratory Medicine Authors: Koichiro KamioArata AzumaKen OhtaYukihiko SugiyamaToshihiro NukiwaShoji KudohTohru Mizushima Source Type: research

Relationship of redundant Th17 cells and IL-17A, but not IL-17 F, with the severity of obstructive sleep apnoea/hypopnoea syndrome (OSAHS)
Background: The pathogenesis of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), a highly prevalent disease, is not completely understood. The purpose of this study was to investigate the contributions of Th17 cells and the Th17-associated cytokines IL-17A and IL-17 F to OSAHS. Methods: 46 male patients with a clinical suspicion of OSAHS were enrolled and divided into four groups based on their polysomnography results: controls and mild, moderate, and severe OSAHS. The serum levels of IL-17A and IL-17 F were determined by enzyme linked immunosorbent assay (ELISA), pulmonary arterial pressure (PAP) was determi...
Source: BMC Pulmonary Medicine - Latest articles - May 15, 2014 Category: Respiratory Medicine Authors: Lin YingHequan LiZhijie PanShanni MaPei ZhangQing WangGuohua LuJianying Zhou Source Type: research

Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy
Conclusion: Considering this remarkable response to crizotinib, we can safely conclude that patients with squamous cell lung cancer should have the option of undergoing ALK testing to determine if there is indication for crizotinib treatment even after they have failed chemotherapy. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 15, 2014 Category: Respiratory Medicine Authors: Qiushi WangYong HeXin YangYubo WangHualiang Xiao Source Type: research

Relationship of redundant Th17 cells and IL-17A, but not IL-17 F, with the severity of obstructive sleep apnoea/hypopnoea syndrome (OSAHS)
Background: The pathogenesis of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), a highly prevalent disease, is not completely understood. The purpose of this study was to investigate the contributions of Th17 cells and the Th17-associated cytokines IL-17A and IL-17 F to OSAHS. Methods: 46 male patients with a clinical suspicion of OSAHS were enrolled and divided into four groups based on their polysomnography results: controls and mild, moderate, and severe OSAHS. The serum levels of IL-17A and IL-17 F were determined by enzyme linked immunosorbent assay (ELISA), pulmonary arterial pressure (PAP) was determined by ech...
Source: BMC Pulmonary Medicine - Latest articles - May 15, 2014 Category: Respiratory Medicine Authors: Lin YingHequan LiZhijie PanShanni MaPei ZhangQing WangGuohua LuJianying Zhou Source Type: research

Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD
Conclusions: Blocking CD137 expression is associated with downregulation of IFNgamma, TNFalpha and granzyme B by CD8+ T and NKT-like and NK cells. Targeting CD137 may have novel therapeutic implications for patients with COPD. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 15, 2014 Category: Respiratory Medicine Authors: Greg HodgeMark HolmesHubertus JersmannPaul ReynoldsSandra Hodge Source Type: research

Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from Cystic Fibrosis patients during intravenous antibiotic treatment
Conclusions: Analysis of NLF inflammatory markers revealed considerable differences between controls and CF patients, with significant changes during systemic i.v. AB treatment within just 6 days. Thus, our data support further investigation into the collection of samples from the epithelial surface of the upper airways by nasal lavage as a potential diagnostic and research tool. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 13, 2014 Category: Respiratory Medicine Authors: Julia HentschelManuela JägerNatalie BeiersdorfNele FischerFranziska DohtRuth MichlThomas LehmannUdo MarkertKlas BöerPeter KellerMathias PletzJochen Mainz Source Type: research

Bronchial asthma is associated with increased risk of chronic kidney disease
This study aims to clarify the association between bronchial asthma and the risk of developing chronic kidney disease. Methods: The National Health Research Institute provided a database of one million random subjects for the study. A random sample of 141 064 patients aged>=18 years without a history of kidney disease was obtained from the database. Among them, there were 35 086 with bronchial asthma and 105 258 without asthma matched for sex and age for a ration of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing chronic kidney disease during...
Source: BMC Pulmonary Medicine - Latest articles - May 8, 2014 Category: Respiratory Medicine Authors: Hui-Ling HuangShinn-Ying HoChien-Hsun LiFang-Ying ChuLi-Ping CiouHua-Chin LeeWen-Liang ChenNian-Sheng Tzeng Source Type: research

Usefulness of reinforcing interventions on continuous positive airway pressure compliance
Conclusions: Our findings suggest that it is important that adequate time and effort is spent to ensure patient comfort at the time of CPAP therapy start to optimize acceptance and adherence to treatment, and suggest that it is necessary to maintain reinforcing interventions over time. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 3, 2014 Category: Respiratory Medicine Authors: Anna Lo BueAdriana SalvaggioSerena Iacono IsidoroSalvatore RomanoOreste MarroneGiuseppe Insalaco Source Type: research

Genetic test to stop smoking (GeTSS) trial protocol: randomised controlled trial of a genetic test (Respiragene) and Auckland formula to assess lung cancer risk
The objective of this trial is to determine if this motivator is as effective in subjects recruited from an NHS primary care unit.Method/Design: Subjects will be recruited by mailings using smoking entries on the GP electronic data-base (total practice population = 32,048) to identify smokers who may want to quit. Smoking cessation clinics based on medical centre premises will run for eight weeks. Clinics will be randomised to have the gene-based test for estimation of lung cancer risk or to act as controls groups. The primary endpoint will be smoking cessation at eight weeks and six months. Secondary outcomes will include...
Source: BMC Pulmonary Medicine - Latest articles - May 1, 2014 Category: Respiratory Medicine Authors: John NicholsPaul GrobSimon de LusignanWendy KitePeter Williams Source Type: research

Assessment of stigma in patients with cystic fibrosis
Conclusions: Stigma is measurable and significantly impacts the lives of CF patients. Further research should investigate the role of stigma in patients living with CF. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 1, 2014 Category: Respiratory Medicine Authors: Smita PakhaleMichael ArmstrongCrystal HollyRojiemiahd EdjocEna GaudetShawn AaronGiorgio TascaWilliam CameronLouise Balfour Source Type: research

Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease
Background: Adult patients with cystic fibrosis (CF) frequently have reduced exercise tolerance, which is multifactorial but mainly due to bronchial obstruction. The aim of this retrospective analysis was to determine the mechanisms responsible for exercise intolerance in patients with mild-to-moderate or severe disease. Methods: Cardiopulmonary exercise testing with blood gas analysis at peak exercise was performed in 102 patients aged 28 +/- 11 years: 48 patients had severe lung disease (FEV1 = 50%, group 2). VO2 peak was measured and correlated with clinical, biological, and functional parameters. Results: VO2 peak for ...
Source: BMC Pulmonary Medicine - Latest articles - April 30, 2014 Category: Respiratory Medicine Authors: Jean PastréAnne PrévotatCatherine TardifCarole LangloisAlain DuhamelBenoit Wallaert Source Type: research

Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts
Conclusions: In these two cohorts, HIV is an independent risk factor for several respiratory symptoms and pulmonary diseases including COPD and sleep apnea. Despite a higher prevalence of chronic respiratory symptoms, testing for non-infectious respiratory diseases may be underutilized in the HIV-infected population. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 30, 2014 Category: Respiratory Medicine Authors: Matthew GingoGoundappa BalasubramaniThomas RiceLawrence KingsleyEric KleerupRoger DetelsEric SeabergRuth GreenblattSusan HolmanLaurence HuangSarah SuttonMarnie BertoletAlison Morris Source Type: research

Determination of respiratory gas flow by electrical impedance tomography in an animal model of mechanical ventilation
Conclusions: We conclude that the presented method is able to determine global respiratory gas flow of the lung in different phases of the respiratory cycle. Additionally, it delivers meaningful insight into regional pulmonary characteristics, i.e. the regional ability of the lung to take up and to release air. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 29, 2014 Category: Respiratory Medicine Authors: Marc BodensteinStefan BoehmeStephan BierschockAndreas VogtMatthias DavidKlaus Markstaller Source Type: research

Exacerbations in patients with chronic obstructive pulmonary disease receiving physical therapy: a cohort-nested randomised controlled trial
This study aims to investigate the potential of a protocol-directed physical therapy programme as a means to prevent or postpone exacerbations, to shorten the duration or to decrease the severity of exacerbations in patients with COPD who have recently experienced an exacerbation. Besides, this study focuses on the effect of protocol-directed physical therapy on health status and quality of life and on cost-effectiveness and cost-utility in patients with COPD who have recently experienced an exacerbation. Methods: A prospective cohort of 300 COPD patients in all GOLD stages will be constructed. Patients will receive usual ...
Source: BMC Pulmonary Medicine - Latest articles - April 26, 2014 Category: Respiratory Medicine Authors: Emmylou BeekmanIlse MestersErik HendriksJean MurisGeertjan WesselingSilvia EversGuus AsijeeAnnemieke FastenauHannah HoffenkampRik GosselinkOnno van SchayckRob de Bie Source Type: research

Soluble receptor for advanced glycation end-products and progression of airway disease
Conclusions: Lower plasma concentrations of sRAGE were associated with greater progression of airflow limitations over time, especially in smokers with COPD, suggesting that RAGE might have a protective role in the lung. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 24, 2014 Category: Respiratory Medicine Authors: Hiroshi IwamotoJing GaoVille PulkkinenTuula ToljamoPentti NieminenWitold Mazur Source Type: research

Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
Conclusions: The results in this study revealed that alveolar epithelial cells underwent epithelial-mesenchymal transition and may be an important origin of myofibroblasts in the progression of acute interstitial pneumonia. Conducting research on the transformation of alveolar epithelial cells into myofibroblasts in the lung tissue of patients with acute interstitial pneumonia may be beneficial for the treatment of this disease. However, to our knowledge, no research has been conducted on this topic. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 23, 2014 Category: Respiratory Medicine Authors: Hongbo LiJinjin ZhangXiaodong SongTao WangZhi LiDong HaoXiaozhi WangQingyin ZhengCuiping MaoPan XuChangjun Lv Source Type: research

Comparative chest computed tomography findings of non-tuberculous mycobacterial lung diseases and pulmonary tuberculosis in patients with afb smear-positive sputum
Background: Early diagnosis and treatment of nontuberculous mycobacterial lung diseases (NTM-LD) and pulmonary tuberculosis (PTB) are important clinical issues. The present study aimed to compare and identify the chest CT characteristics that help to distinguish NTM lung disease from PTB in patients with acid-fast bacilli (AFB) smear-positive sputum. Methods: From January 2009 to April 2012, we received 467 AFB smear-positive sputum specimens. A total of 95 CT scans obtained from the 159 patients were analyzed, 75 scans were from patients with PTB and 20 scans from NTM-LD. The typical chest CT findings of mycobacterial dis...
Source: BMC Pulmonary Medicine - Latest articles - April 22, 2014 Category: Respiratory Medicine Authors: Mei-Kang YuanCheng-Yu ChangPing-Huang TsaiYuan-Ming LeeJen-Wu HuangShih-Chieh Chang Source Type: research

Internet access and use by COPD patients in the National Emphysema/COPD Association Survey
Conclusions: An analysis of the characteristics associated with Internet access and use among COPD patients identified two different patient populations. Lack of Internet access was a marker of socioeconomic disparity and mobility-associated diseases, while frequent Internet use was associated with less somatic disease but dissatisfaction with care. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 22, 2014 Category: Respiratory Medicine Authors: Carlos MartinezBeth St JeanCraig PlauschinatBarbara RogersJulen BeresfordFernando MartinezCaroline RichardsonMeiLan Han Source Type: research

Longterm follow-up in European respiratory health studies ¿ patterns and implications
Conclusions: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Ane JohannessenGiuseppe VerlatoBryndis BenediktsdottirBertil ForsbergKarl FranklinThorarinn GislasonMathias HolmChrister JansonRain JögiEva LindbergFerenc MacsaliErnst OmenaasFrancisco RealEirunn SaureVivi SchlünssenTorben SigsgaardTrude SkorgeCecilie S Source Type: research

Swallowing transit times and valleculae residue in stable chronic obstructive pulmonary disease
Conclusions: Our study suggests that stable COPD patients may present physiological adaptations as a protective swallowing maneuver to avoid aspiration/penetration of pharyngeal contents. Moreover, valleculae residue cannot be seen as an isolated factor when trying to explain swallowing alterations in this population. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Rosane de Deus ChavesFernanda Chiarion SassiLaura Davison MangilliShri JayanthiAlberto CukierBruno ZilbersteinClaudia Furquim de Andrade Source Type: research

Longterm follow-up in European respiratory health studies - patterns and implications
Conclusions: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Ane JohannessenGiuseppe VerlatoBryndis BenediktsdottirBertil ForsbergKarl FranklinThorarinn GislasonMathias HolmChrister JansonRain JögiEva LindbergFerenc MacsaliErnst OmenaasFrancisco RealEirunn SaureVivi SchlünssenTorben SigsgaardTrude SkorgeCecilie S Source Type: research

Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis
Conclusions: Both pleural cholesterol level and the P/S cholesterol ratio are helpful for the diagnosis of pleural exudates. Nevertheless, the results of pleural cholesterol assays should be interpreted in parallel with the results of traditional tests and clinical information. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 15, 2014 Category: Respiratory Medicine Authors: Yongchun ShenHong ZhuChun WanLei ChenTao WangTing YangFuqiang Wen Source Type: research

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial
Conclusion: Whole body vibration during hospitalised exacerbations did not cause procedure-related adverse events and induced clinically significant benefits regarding exercise capacity and health-related quality of life that were associated with increased serum levels of irisin, a marker of muscle activity.Trial registration: German Clinical Trials Register DRKS00005979. Registered 17 March 2014. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 11, 2014 Category: Respiratory Medicine Authors: Timm GreulichChristoph NellJanine KoepkeJuliane FechtelMaja FrankeBernd SchmeckDaniel HaidSandra ApeltSilke FilipovicKlaus KennSabina JanciauskieneClaus VogelmeierAndreas Koczulla Source Type: research

Transient vascular and long-term alveolar deficits following a hyperoxic injury to neonatal mouse lung
Conclusions: This study suggests that administration of high oxygen to underdeveloped lungs has a transient reductive effect on secondary septal number and pulmonary vascularization and a significant long-term reduction in alveolarization persisting into adulthood. This model can be used for future research of premature lung disease therapies in humans, addressing these short term septal and vascular and long term alveolar deficits, specifically relating to injury by hyperoxia. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 9, 2014 Category: Respiratory Medicine Authors: Alexandra FirsovaTimothy ColeRichard Mollard Source Type: research

Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-¿ for the evaluation of pleural tuberculosis: a prospective cohort study
Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. Methods: Smear-microscopy, adenosine deaminase (ADA), interferon gamma (IFN-γ), and Xpert MTB/RIF [using an unprocessed (1 ml) and centrifuged (~20 ml) sample] test accuracy was evaluated in pleural fluid from 103 consecutive patients with suspected pleural TB. Culture for M.tuberculosis and/or histopathology (pleural biopsy) served as the reference standard. Patients were followed p...
Source: BMC Pulmonary Medicine - Latest articles - April 8, 2014 Category: Respiratory Medicine Authors: Richard MeldauJonny PeterGrant TheronGreg CalligaroBrian AllwoodGreg SymonsHoosain KhalfeyGina NtombenhleUreshnie GovenderAnke BinderRichard van Zyl-SmitKeertan Dheda Source Type: research

Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-gamma for the evaluation of pleural tuberculosis: a prospective cohort study
Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. Methods: Smear-microscopy, adenosine deaminase (ADA), interferon gamma (IFN-gamma), and Xpert MTB/RIF [using an unprocessed (1 ml) and centrifuged (~20 ml) sample] test accuracy was evaluated in pleural fluid from 103 consecutive patients with suspected pleural TB. Culture for M.tuberculosis and/or histopathology (pleural biopsy) served as the reference standard. Patients were followed pro...
Source: BMC Pulmonary Medicine - Latest articles - April 8, 2014 Category: Respiratory Medicine Authors: Richard MeldauJonny PeterGrant TheronGreg CalligaroBrian AllwoodGreg SymonsHoosain KhalfeyGina NtombenhleUreshnie GovenderAnke BinderRichard van Zyl-SmitKeertan Dheda Source Type: research