A coumarin-furoxan hybrid as novel nitric oxide donor induced cell apoptosis and ferroptosis in NSCLC by promoting S-nitrosylation of STAT3 and negative regulation of JAK2-STAT3 pathway
In this study, we evaluated the inhibitory effect of a new coumarin-furoxan hybrid compound 9, a nitric oxide (NO) donor drug, on NSCLC proliferation and its mechanism. Our results show that compound 9 can inhibit the growth of four NSCLC cell lines and H1975 xenograft model in a dose-dependent manner. Compound 9 effectively releases high concentrations of NO within the mitochondria, leading to cellular oxidative stress, mitochondrial dysfunction, and apoptosis. Moreover, compound 9 inhibits JAK2/STAT3 protein phosphorylation and induces S-nitrosylation modification of STAT3, ultimately resulting in endogenous apoptosis in...
Source: Biochemical Pharmacology - February 22, 2024 Category: Drugs & Pharmacology Authors: Fan Cao Mengru Li Weijie Wang Yi Yi Ying Chen Hongrui Liu Source Type: research
IL-23p19 deficiency reduces M1 macrophage polarization and improves stress-induced cardiac remodeling by alleviating macrophage ferroptosis in mice
CONCLUSION: Knockout of IL-23p19 may attenuate M1 macrophage polarization to improve the cardiac remodeling process by reducing macrophage ferroptosis, and IL-23p19 may be a potential target for the prevention and treatment of cardiac remodeling.PMID:38387530 | DOI:10.1016/j.bcp.2024.116072 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - February 22, 2024 Category: Drugs & Pharmacology Authors: Xiyi Lu Qingwei Ji Heng Pan Yongqi Feng Di Ye Liren Gan Jun Wan Jing Ye Source Type: research
Commentary: Fifty years exploring pharmacology with Sam Enna
Biochem Pharmacol. 2024 Feb 19:116067. doi: 10.1016/j.bcp.2024.116067. Online ahead of print.ABSTRACTThe passing of Sam Enna in June of 2023 is major loss to the world of pharmacology. While best known for his extensive research activities in the area of γ-aminobutyric acid (GABA) pharmacology, Sam devoted much of his professional time to teaching and as an Editor in Chief for the legacy journals - the Journal of Pharmacology and Experimental Therapeutics (JPET - 1998-2003); Pharmacology & Therapeutics (P & T - 2003-2023) and Biochemical Pharmacology (BCP -2003-2023) - increasing the volume of submissions for all ...
Source: Biochemical Pharmacology - February 21, 2024 Category: Drugs & Pharmacology Authors: Michael Williams Source Type: research
Commentary: Fifty years exploring pharmacology with Sam Enna
Biochem Pharmacol. 2024 Feb 19:116067. doi: 10.1016/j.bcp.2024.116067. Online ahead of print.ABSTRACTThe passing of Sam Enna in June of 2023 is major loss to the world of pharmacology. While best known for his extensive research activities in the area of γ-aminobutyric acid (GABA) pharmacology, Sam devoted much of his professional time to teaching and as an Editor in Chief for the legacy journals - the Journal of Pharmacology and Experimental Therapeutics (JPET - 1998-2003); Pharmacology & Therapeutics (P & T - 2003-2023) and Biochemical Pharmacology (BCP -2003-2023) - increasing the volume of submissions for all ...
Source: Biochemical Pharmacology - February 21, 2024 Category: Drugs & Pharmacology Authors: Michael Williams Source Type: research
Developing CAR-immune cell therapy against SARS-CoV-2: Current status, challenges and prospects
Biochem Pharmacol. 2024 Feb 17;222:116066. doi: 10.1016/j.bcp.2024.116066. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-immune cell therapy has revolutionized the anti-tumor field, achieving efficient and precise tumor clearance by directly guiding immune cell activity to target tumors. In addition, the use of CAR-immune cells to influence the composition and function of the immune system and ultimately achieve virus clearance and immune system homeostasis has attracted the interest of researchers. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered a global pandemic of coronavirus disea...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Yizhao Chen Chong Liu Yilong Fang Weile Chen Jiaqi Qiu Mengjuan Zhu Wei Wei Jiajie Tu Source Type: research
Non-genomic actions of steroid hormones on the contractility of non-vascular smooth muscles
Biochem Pharmacol. 2024 Feb 17:116063. doi: 10.1016/j.bcp.2024.116063. Online ahead of print.ABSTRACTSteroid hormones play an important role in physiological processes. The classical pathway of steroid actions is mediated by nuclear receptors, which regulate genes to modify biological processes. Non-genomic pathways of steroid actions are also known, mediated by cell membrane-located seven transmembrane domain receptors. Sex steroids and glucocorticoids have several membrane receptors already identified to mediate their rapid actions. However, mineralocorticoids have no identified membrane receptors, although their rapid a...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Saif-Alnasr H Mohammed Mohsen Mirdamadi Kalman F Szucs Robert Gaspar Source Type: research
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
In this study, we investigated the HDAC inhibitor, panobinostat, in combination with VEN + AZA against AraC-resistant AML cells. Panobinostat treatment downregulated c-Myc and Bcl-xL and upregulated Bim, which enhanced the antileukemic activity of VEN + AZA against AraC-resistant AML cells. In addition, panobinostat alone and in combination with VEN + AZA suppressed oxidative phosphorylation and/or glycolysis in AraC-resistant AML cells. These findings support further development of panobinostat in combination with VEN + AZA for the treatment of AraC-resistant AML.PMID:38373594 | DOI:10.1016/j.bcp.2024.116065 (Source: Bioc...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Jianlei Zhao Shuangshuang Wu Deying Wang Holly Edwards Jenna Thibodeau Seongho Kim Paul Stemmer Guan Wang Jingji Jin S üreyya Savasan Jeffrey W Taub Yubin Ge Source Type: research
Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease
This study aimed to: outline the diagnostic and delivery roles of MSCs-EVs for AD treatment; summarize the optimal sources and delivery methods of MSCs-EVs; provide a comprehensive review on the neuroprotective mechanisms of MSCs-EVs; explore how to enhance the neuroprotective effects of MSCs-EVs; and discuss the limitations and potential of their translation to the clinic. Therefore, this study may provide a more precise theoretical reference and practical basis for clinical research of MSCs-EVs.PMID:38373595 | DOI:10.1016/j.bcp.2024.116064 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Jun Chang Zihang Feng Yujiao Li Honglin Lv Shuzhen Liu Yongyin Luo Nan Hao Lan Zhao Jianwei Liu Source Type: research
Developing CAR-immune cell therapy against SARS-COV-2: Current status, challenges, and prospects
Biochem Pharmacol. 2024 Feb 17:116066. doi: 10.1016/j.bcp.2024.116066. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-immune cell therapy has revolutionized the anti-tumor field, achieving efficient and precise tumor clearance by directly guiding immune cell activity to target tumors. In addition, the use of CAR-immune cells to influence the composition and function of the immune system and ultimately achieve virus clearance and immune system homeostasis has attracted the interest of researchers. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered a global pandemic of coronavirus disease 2...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Yizhao Chen Chong Liu Yilong Fang Weile Chen Jiaqi Qiu Mengjuan Zhu Wei Wei Jiajie Tu Source Type: research
Non-genomic actions of steroid hormones on the contractility of non-vascular smooth muscles
Biochem Pharmacol. 2024 Feb 17:116063. doi: 10.1016/j.bcp.2024.116063. Online ahead of print.ABSTRACTSteroid hormones play an important role in physiological processes. The classical pathway of steroid actions is mediated by nuclear receptors, which regulate genes to modify biological processes. Non-genomic pathways of steroid actions are also known, mediated by cell membrane-located seven transmembrane domain receptors. Sex steroids and glucocorticoids have several membrane receptors already identified to mediate their rapid actions. However, mineralocorticoids have no identified membrane receptors, although their rapid a...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Saif-Alnasr H Mohammed Mohsen Mirdamadi Kalman F Szucs Robert Gaspar Source Type: research
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
In this study, we investigated the HDAC inhibitor, panobinostat, in combination with VEN + AZA against AraC-resistant AML cells. Panobinostat treatment downregulated c-Myc and Bcl-xL and upregulated Bim, which enhanced the antileukemic activity of VEN + AZA against AraC-resistant AML cells. In addition, panobinostat alone and in combination with VEN + AZA suppressed oxidative phosphorylation and/or glycolysis in AraC-resistant AML cells. These findings support further development of panobinostat in combination with VEN + AZA for the treatment of AraC-resistant AML.PMID:38373594 | DOI:10.1016/j.bcp.2024.116065 (Source: Bioc...
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Jianlei Zhao Shuangshuang Wu Deying Wang Holly Edwards Jenna Thibodeau Seongho Kim Paul Stemmer Guan Wang Jingji Jin S üreyya Savasan Jeffrey W Taub Yubin Ge Source Type: research
Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease
This study aimed to: outline the diagnostic and delivery roles of MSCs-EVs for AD treatment; summarize the optimal sources and delivery methods of MSCs-EVs; provide a comprehensive review on the neuroprotective mechanisms of MSCs-EVs; explore how to enhance the neuroprotective effects of MSCs-EVs; and discuss the limitations and potential of their translation to the clinic. Therefore, this study may provide a more precise theoretical reference and practical basis for clinical research of MSCs-EVs.PMID:38373595 | DOI:10.1016/j.bcp.2024.116064 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - February 19, 2024 Category: Drugs & Pharmacology Authors: Jun Chang Zihang Feng Yujiao Li Honglin Lv Shuzhen Liu Yongyin Luo Nan Hao Lan Zhao Jianwei Liu Source Type: research
Angiotensin AT < sub > 2 < /sub > receptors reduce inflammation and fibrosis in cardiovascular remodeling
Biochem Pharmacol. 2024 Feb 16:116062. doi: 10.1016/j.bcp.2024.116062. Online ahead of print.ABSTRACTThe angiotensin AT2 receptor (AT2R), an important member of the "protective arm" of the renin-angiotensin system (RAS), has been recently defined as a therapeutic target in different pathological conditions. The AT2R activates complex signalling pathways linked to cellular proliferation, differentiation, anti-inflammation, antifibrosis, and induction or inhibition of apoptosis. The anti-inflammatory effect of AT2R activation is commonly associated with reduced fibrosis in different models. Current discoveries demonstrated a...
Source: Biochemical Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Elena Kaschina Dilyara Lauer Christoph Lange Thomas Unger Source Type: research
Activin receptors in human cancer: Functions, mechanisms, and potential clinical applications
Biochem Pharmacol. 2024 Feb 16;222:116061. doi: 10.1016/j.bcp.2024.116061. Online ahead of print.ABSTRACTActivins are members of the transforming growth factor-β (TGF-β) superfamily and act as key regulators in various physiological processes, such as follicle and embryonic development, as well as in multiple human diseases, including cancer. They have been established to signal through three type I and two type II serine/threonine kinase receptors, which, upon ligand binding, form a final signal-transducing receptor complex that activates downstream signaling and governs gene expression. Recent research highlighted the ...
Source: Biochemical Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Ruochen Du Liqi Wen Min Niu Liting Zhao Xiaoya Guan Jiao Yang Chunming Zhang Hongliang Liu Source Type: research
Angiotensin AT < sub > 2 < /sub > receptors reduce inflammation and fibrosis in cardiovascular remodeling
Biochem Pharmacol. 2024 Feb 16:116062. doi: 10.1016/j.bcp.2024.116062. Online ahead of print.ABSTRACTThe angiotensin AT2 receptor (AT2R), an important member of the "protective arm" of the renin-angiotensin system (RAS), has been recently defined as a therapeutic target in different pathological conditions. The AT2R activates complex signalling pathways linked to cellular proliferation, differentiation, anti-inflammation, antifibrosis, and induction or inhibition of apoptosis. The anti-inflammatory effect of AT2R activation is commonly associated with reduced fibrosis in different models. Current discoveries demonstrated a...
Source: Biochemical Pharmacology - February 18, 2024 Category: Drugs & Pharmacology Authors: Elena Kaschina Dilyara Lauer Christoph Lange Thomas Unger Source Type: research
