From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers
Biochem Pharmacol. 2024 Mar 2:116107. doi: 10.1016/j.bcp.2024.116107. Online ahead of print.ABSTRACTCancer is a comprehensive classification encompassing more than 100 forms of malignancies that manifest in diverse tissues within the human body. Recent studies have provided evidence that aberrant epigenetic modifications are pivotal indicators of cancer. Epigenetics encapsulates DNA methyltransferases as a crucial class of modifiers. DNMTs, including DNMT3A, assume central roles in DNA methylation processes that orchestrate normal biological functions, such as gene transcription, predominantly in mammals. Typically, deviat...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Chunjie Huang Seyed Mohsen Aghaei-Zarch Source Type: research
Toll-like receptor signalling as a cannabinoid target
Biochem Pharmacol. 2024 Mar 2:116082. doi: 10.1016/j.bcp.2024.116082. Online ahead of print.ABSTRACTToll-like receptors (TLRs) have become a focus in biomedicine and biomedical research given the roles of this unique family of innate immune proteins in immune activation, infection, and autoimmunity. It is evident that TLR dysregulation, and subsequent alterations in TLR-mediated inflammatory signalling, can contribute to disease pathogenesis, and TLR targeted therapies are in development. This review highlights evidence that cannabinoids are key regulators of TLR signalling. Cannabinoids include component of the plant Cann...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Melody Cui Sun Almudena Ot álora-Alcaraz Jack A Prenderville Eric J Downer Source Type: research
Adipose tissue-derived stem cells, in vivo and in vitro models for metabolic diseases
Biochem Pharmacol. 2024 Mar 2:116108. doi: 10.1016/j.bcp.2024.116108. Online ahead of print.ABSTRACTThe primary role of adipose tissue stem cells (ADSCs) is to support the function and homeostasis of adipose tissue in physiological and pathophysiological conditions. However, when ADSCs become dysfunctional in diseases such as obesity and cancer, they become impaired, undergo signalling changes, and their epigenome is altered, which can have a dramatic effect on human health. In more recent years, the therapeutic potential of ADSCs in regenerative medicine, wound healing, and for treating conditions such as cancer and metab...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Jaime Navarro-Perez Stefania Carobbio Source Type: research
From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers
Biochem Pharmacol. 2024 Mar 2:116107. doi: 10.1016/j.bcp.2024.116107. Online ahead of print.ABSTRACTCancer is a comprehensive classification encompassing more than 100 forms of malignancies that manifest in diverse tissues within the human body. Recent studies have provided evidence that aberrant epigenetic modifications are pivotal indicators of cancer. Epigenetics encapsulates DNA methyltransferases as a crucial class of modifiers. DNMTs, including DNMT3A, assume central roles in DNA methylation processes that orchestrate normal biological functions, such as gene transcription, predominantly in mammals. Typically, deviat...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Chunjie Huang Seyed Mohsen Aghaei-Zarch Source Type: research
Toll-like receptor signalling as a cannabinoid target
Biochem Pharmacol. 2024 Mar 2:116082. doi: 10.1016/j.bcp.2024.116082. Online ahead of print.ABSTRACTToll-like receptors (TLRs) have become a focus in biomedicine and biomedical research given the roles of this unique family of innate immune proteins in immune activation, infection, and autoimmunity. It is evident that TLR dysregulation, and subsequent alterations in TLR-mediated inflammatory signalling, can contribute to disease pathogenesis, and TLR targeted therapies are in development. This review highlights evidence that cannabinoids are key regulators of TLR signalling. Cannabinoids include component of the plant Cann...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Melody Cui Sun Almudena Ot álora-Alcaraz Jack A Prenderville Eric J Downer Source Type: research
Adipose tissue-derived stem cells, in vivo and in vitro models for metabolic diseases
Biochem Pharmacol. 2024 Mar 2:116108. doi: 10.1016/j.bcp.2024.116108. Online ahead of print.ABSTRACTThe primary role of adipose tissue stem cells (ADSCs) is to support the function and homeostasis of adipose tissue in physiological and pathophysiological conditions. However, when ADSCs become dysfunctional in diseases such as obesity and cancer, they become impaired, undergo signalling changes, and their epigenome is altered, which can have a dramatic effect on human health. In more recent years, the therapeutic potential of ADSCs in regenerative medicine, wound healing, and for treating conditions such as cancer and metab...
Source: Biochemical Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Authors: Jaime Navarro-Perez Stefania Carobbio Source Type: research
Corrigendum to "Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1 β and IL-18'' [Biochem. Pharmacol. 155 (2018) 150-161]
Biochem Pharmacol. 2024 Mar 2;222:116089. doi: 10.1016/j.bcp.2024.116089. Online ahead of print.NO ABSTRACTPMID:38432053 | DOI:10.1016/j.bcp.2024.116089 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 3, 2024 Category: Drugs & Pharmacology Authors: Daniela Impellizzeri Rosalba Siracusa Marika Cordaro Alessio Filippo Peritore Enrico Gugliandolo Giuseppe Mancuso Angelina Midiri Rosanna Di Paola Salvatore Cuzzocrea Source Type: research
Corrigendum to "Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR- δ agonism correlates with impaired NLRP3 inflammasome activation'' [Biochem. Pharmacol. 85(2) (2013) 257-264]
Biochem Pharmacol. 2024 Mar 1;222:116060. doi: 10.1016/j.bcp.2024.116060. Online ahead of print.NO ABSTRACTPMID:38430671 | DOI:10.1016/j.bcp.2024.116060 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Authors: Massimo Collino Elisa Benetti Mara Rogazzo Raffaella Mastrocola Muhammed M Yaqoob Manuela Aragno Christroph Theimermann Roberto Fantozzi Source Type: research
Lactic acid in macrophage polarization: A factor in carcinogenesis and a promising target for cancer therapy
Biochem Pharmacol. 2024 Feb 29;222:116098. doi: 10.1016/j.bcp.2024.116098. Online ahead of print.ABSTRACTCancer remains a formidable challenge, continually revealing its intricate nature and demanding novel treatment approaches. Within this intricate landscape, the tumor microenvironment and its dynamic components have gained prominence, particularly macrophages that can adopt diverse polarization states, exerting a profound influence on cancer progression. Recent revelations have spotlighted lactic acid as a pivotal player in this complex interplay. This review systematically explores lactic acid's multifaceted role in ma...
Source: Biochemical Pharmacology - March 2, 2024 Category: Drugs & Pharmacology Authors: Mobarakeh Ajam-Hosseini Romina Heydari Milad Rasouli Fatemeh Akhoondi Niloofar Asadi Hanjani Sander Bekeschus Mohammad Doroudian Source Type: research
Expression and function of VISTA on myeloid cells
Biochem Pharmacol. 2024 Feb 28:116100. doi: 10.1016/j.bcp.2024.116100. Online ahead of print.ABSTRACTV-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, inclu...
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Siyu Li Geng Wang Yan Ren Xinyue Liu Yixuan Wang Jianing Li Hua Liu Jiaqiang Yang Jingjun Xing Yanru Zhang Canxia He Suling Xu Xin Hou Na Li Source Type: research
Deletion of hepatocyte cysteine dioxygenase type 1, a bile acid repressed gene, enhances glutathione synthesis and ameliorates acetaminophen hepatotoxicity
Biochem Pharmacol. 2024 Feb 28;222:116103. doi: 10.1016/j.bcp.2024.116103. Online ahead of print.ABSTRACTLiver is a major organ that metabolizes sulfur amino acids cysteine, which is the substrate for the synthesis of many essential cellular molecules including GSH, taurine, and coenzyme A. Bile acid-activated farnesoid x receptor (FXR) inhibits cysteine dioxygenase type 1 (CDO1), which mediates hepatic cysteine catabolism and taurine synthesis. To define the impact of bile acid inhibition of CDO1 on hepatic sulfur amino acid metabolism and antioxidant capacity, we developed hepatocyte-specific CDO1 knockout mice (Hep-CDO1...
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Jianglei Chen David Matye Yung Dai Clayton Yanhong Du Mohammad Nazmul Hasan Lijie Gu Tiangang Li Source Type: research
The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases
Biochem Pharmacol. 2024 Feb 29;222:116104. doi: 10.1016/j.bcp.2024.116104. Online ahead of print.ABSTRACTAdipose tissues (AT) are an important endocrine organ that secretes various functional adipokines, peptides, non-coding RNAs, and acts on AT themselves or other distant tissues or organs through autocrine, paracrine, or endocrine manners. An accumulating body of evidence has suggested that many adipokines play an important role in liver metabolism. Besides the traditional adipokines such as adiponectin and leptin, many novel adipokines have recently been identified to have regulatory effects on the liver. Additionally, ...
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Lijun Xie Huiying Wang Jinying Hu Zhuoying Liu Fang Hu Source Type: research
Proliferation and migration of PC-3 prostate cancer cells is counteracted by PPAR γ-cladosporol binding-mediated apoptosis and a decreased lipid biosynthesis and accumulation
CONCLUSION: This is the first work, to our knowledge, in which the role of cladosporols A and B was disclosed in prostate cancer cells. Importantly, the present study highlighted the potential of cladosporols as new therapeutical tools, which, interfering with cell proliferation and lipid pathway dysregulation, may control prostate cancer initiation and progression.PMID:38428827 | DOI:10.1016/j.bcp.2024.116097 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Roberta Rapuano Alessio Riccio Antonella Mercuri Jessica Raffaella Madera Sabrina Dallavalle Salvatore Moricca Angelo Lupo Source Type: research
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease
In conclusion, STING deficiency protected against diabetic renal injury via alleviating ferroptosis through stabilizing FPN1 and reducing oxidative stress, providing a possible potential approach for the treatment of DKD.PMID:38428828 | DOI:10.1016/j.bcp.2024.116102 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Qin-Xiao Zhao Sen-Bo Yan Fen Wang Xiao-Xing Li Guo-Kai Shang Zi-Jie Zheng Jie Xiao Zong-Wei Lin Chuan-Bao Li Xiao-Ping Ji Source Type: research
Expression and function of VISTA on myeloid cells
Biochem Pharmacol. 2024 Feb 28:116100. doi: 10.1016/j.bcp.2024.116100. Online ahead of print.ABSTRACTV-domain containing Ig Suppressor of T cell Activation (VISTA) is predominantly expressed on myeloid cells and functions as a ligand/receptor/soluble molecule. In inflammatory responses and immune responses, VISTA regulates multiple functions of myeloid cells, such as chemotaxis, phagocytosis, T cell activation. Since inflammation and immune responses are critical in many diseases, VISTA is a promising therapeutic target. In this review, we will describe the expression and function of VISTA on different myeloid cells, inclu...
Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Siyu Li Geng Wang Yan Ren Xinyue Liu Yixuan Wang Jianing Li Hua Liu Jiaqiang Yang Jingjun Xing Yanru Zhang Canxia He Suling Xu Xin Hou Na Li Source Type: research
