Finding new analgesics: Computational pharmacology faces drug discovery challenges
Biochem Pharmacol. 2024 Feb 25:116091. doi: 10.1016/j.bcp.2024.116091. Online ahead of print.ABSTRACTDespite the worldwide prevalence and huge burden of pain, pain is an undertreated phenomenon. Currently used analgesics have several limitations regarding their efficacy and safety. The discovery of analgesics possessing a novel mechanism of action has faced multiple challenges, including a limited understanding of biological processes underpinning pain and analgesia and poor animal-to-human translation. Computational pharmacology is currently employed to face these challenges. In this review, we discuss the theory, methods...
Source: Biochemical Pharmacology - February 27, 2024 Category: Drugs & Pharmacology Authors: Ahmed Barakat Gordon Munro Anne-Marie Heegaard Source Type: research
Finding new analgesics: Computational pharmacology faces drug discovery challenges
Biochem Pharmacol. 2024 Feb 25:116091. doi: 10.1016/j.bcp.2024.116091. Online ahead of print.ABSTRACTDespite the worldwide prevalence and huge burden of pain, pain is an undertreated phenomenon. Currently used analgesics have several limitations regarding their efficacy and safety. The discovery of analgesics possessing a novel mechanism of action has faced multiple challenges, including a limited understanding of biological processes underpinning pain and analgesia and poor animal-to-human translation. Computational pharmacology is currently employed to face these challenges. In this review, we discuss the theory, methods...
Source: Biochemical Pharmacology - February 27, 2024 Category: Drugs & Pharmacology Authors: Ahmed Barakat Gordon Munro Anne-Marie Heegaard Source Type: research
Finding new analgesics: Computational pharmacology faces drug discovery challenges
Biochem Pharmacol. 2024 Feb 25:116091. doi: 10.1016/j.bcp.2024.116091. Online ahead of print.ABSTRACTDespite the worldwide prevalence and huge burden of pain, pain is an undertreated phenomenon. Currently used analgesics have several limitations regarding their efficacy and safety. The discovery of analgesics possessing a novel mechanism of action has faced multiple challenges, including a limited understanding of biological processes underpinning pain and analgesia and poor animal-to-human translation. Computational pharmacology is currently employed to face these challenges. In this review, we discuss the theory, methods...
Source: Biochemical Pharmacology - February 27, 2024 Category: Drugs & Pharmacology Authors: Ahmed Barakat Gordon Munro Anne-Marie Heegaard Source Type: research
The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist
Biochem Pharmacol. 2024 Feb 24:116092. doi: 10.1016/j.bcp.2024.116092. Online ahead of print.ABSTRACTClioquinol (5-chloro-7-iodo-8-hydroxyquinoline) is an antimicrobial agent whose actions as a zinc or copper ionophore and an iron chelator revived the interest in similar compounds for the treatment of fungal and bacterial infections, neurodegeneration and cancer. Recently, we reported zinc ionophores, including clioquinol, cause vasorelaxation in isolated arteries through mechanisms that involve sensory nerves, endothelium and vascular smooth muscle. Here, we report that clioquinol also uniquely acts as a competitive alpha...
Source: Biochemical Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Authors: Ashenafi H Betrie Alaa Abdul-Ridha Herodion Hartono David K Chalmers Christine E Wright Daniel J Scott James A Angus Scott Ayton Source Type: research
Decatastrophizing research irreproducibility
Biochem Pharmacol. 2024 Feb 24:116090. doi: 10.1016/j.bcp.2024.116090. Online ahead of print.ABSTRACTThe reported inability to replicate research findings from the published literature precipitated extensive efforts to identify and correct perceived deficiencies in the execution and reporting of biomedical research. Despite these efforts, quantification of the magnitude of irreproducible research or the effectiveness of associated remediation initiatives, across diverse biomedical disciplines, has made little progress over the last decade. The idea that science is self-correcting has been further challenged in recent years...
Source: Biochemical Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Authors: Michael F Jarvis Source Type: research
