Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs
Biochem Pharmacol. 2024 Mar 20:116156. doi: 10.1016/j.bcp.2024.116156. Online ahead of print.ABSTRACTThe skin, lung, and gut are important barrier organs that control how the body reacts to environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary components, and microorganisms. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that plays an important role in maintaining homeostasis of barrier organs. AhR was initially discovered as a receptor for environmental chemical carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Activation of AhR pathways by PAHs lead...
Source: Biochemical Pharmacology - March 22, 2024 Category: Drugs & Pharmacology Authors: Francoise Congues Pengcheng Wang Joshua Lee Daphne Lin Ayaz Shahid Jianming Xie Ying Huang Source Type: research
Human recombinant relaxin-2 (serelaxin) regulates the proteome, lipidome, lipid metabolism and inflammatory profile of rat visceral adipose tissue
In conclusion, our results highlight the regulatory role of serelaxin in the VAT proteome and lipidome, lipolytic function, and inflammatory profile, suggesting the implication of several mechanisms supporting the potential benefit of serelaxin for the prevention of obesity and metabolic disorders.PMID:38518995 | DOI:10.1016/j.bcp.2024.116157 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 22, 2024 Category: Drugs & Pharmacology Authors: Alana Arag ón-Herrera Sandra Feij óo-Bandín Xocas V ázquez-Abuín Laura Anido-Varela Sandra Mora ña-Fernández Susana B Bravo Estefan ía Tarazón Esther Rosell ó-Lletí Manuel Portol és Javier Garc ía-Seara Jos é Seijas Diego Rodr íguez-Penas D Source Type: research
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs
Biochem Pharmacol. 2024 Mar 20:116156. doi: 10.1016/j.bcp.2024.116156. Online ahead of print.ABSTRACTThe skin, lung, and gut are important barrier organs that control how the body reacts to environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary components, and microorganisms. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that plays an important role in maintaining homeostasis of barrier organs. AhR was initially discovered as a receptor for environmental chemical carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Activation of AhR pathways by PAHs lead...
Source: Biochemical Pharmacology - March 22, 2024 Category: Drugs & Pharmacology Authors: Francoise Congues Pengcheng Wang Joshua Lee Daphne Lin Ayaz Shahid Jianming Xie Ying Huang Source Type: research
Corrigendum to "Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation" [Biochem. Pharmacol. 119 (2016) 27-41]
Biochem Pharmacol. 2024 Mar 20;223:116105. doi: 10.1016/j.bcp.2024.116105. Online ahead of print.NO ABSTRACTPMID:38513506 | DOI:10.1016/j.bcp.2024.116105 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Daniela Impellizzeri Rosanna Di Paola Marika Cordaro Enrico Gugliandolo Giovanna Casili Valeria Maria Morittu Domenico Britti Emanuela Esposito Salvatore Cuzzocrea Source Type: research
Corrigendum to "Involvement of p38 < sup > MAPK < /sup > on the antinociceptive action of myricitrin in mice" [Biochem. Pharmacol. 74 (2007) 924-931]
Biochem Pharmacol. 2024 Mar 20;223:116131. doi: 10.1016/j.bcp.2024.116131. Online ahead of print.NO ABSTRACTPMID:38513507 | DOI:10.1016/j.bcp.2024.116131 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Flavia Carla Meotti Tha ís Posser Fabiana Cristina Missau Moacir Geraldo Pizzolatti Rodrigo Bainy Leal Adair R S Santos Source Type: research
Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin
Biochem Pharmacol. 2024 Mar 20;223:116140. doi: 10.1016/j.bcp.2024.116140. Online ahead of print.ABSTRACTCancer cells consume more glucose and usually overexpress glucose transporters which have become potential targets for the development of anticancer drugs. It has been demonstrated that selective SGLT2 inhibitors, such as canagliflozin and dapagliflozin, display anticancer activity. Here we demonstrated that canagliflozin and dapagliflozin synergistically enhanced the growth inhibitory effect of paclitaxel in cancer cells including ovarian cancer and oral squamous cell carcinoma cells. Canagliflozin also inhibited gluco...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Haoning Huang Fan-Lu Kung Yu-Wen Huang Chun-Chien Hsu Jih-Hwa Guh Lih-Ching Hsu Source Type: research
Targeting non-coding RNAs and N < sup > 6 < /sup > -methyladenosine modification in hepatocellular carcinoma
Biochem Pharmacol. 2024 Mar 19;223:116153. doi: 10.1016/j.bcp.2024.116153. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), the most common form of primary liver cancers, accounts for a significant portion of cancer-related death globally. However, the molecular mechanisms driving the onset and progression of HCC are still not fully understood. Emerging evidence has indicated that non-protein-coding regions of genomes could give rise to transcripts, termed non-coding RNA (ncRNA), forming novel functional driving force for aberrant cellular activity. Over the past decades, overwhelming evidence has denoted invo...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Lin Wu Yingmei Zhang Jun Ren Source Type: research
Wnt signaling: Modulating tumor-associated macrophages and related immunotherapeutic insights
Biochem Pharmacol. 2024 Mar 19;223:116154. doi: 10.1016/j.bcp.2024.116154. Online ahead of print.ABSTRACTWnt signaling pathways are highly conserved cascades that mediate multiple biological processes through canonical or noncanonical pathways, from embryonic development to tissue maintenance, but they also contribute to the pathogenesis of numerous cancers. Recent studies have revealed that Wnt signaling pathways critically control the interplay between cancer cells and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) and potentially impact the efficacy of cancer immunotherapy. In this review, we su...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Yimeng Yuan Dapeng Wu Yifan Hou Yi Zhang Cong Tan Xiaobo Nie Zhenhua Zhao Junqing Hou Source Type: research
Corrigendum to "Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation" [Biochem. Pharmacol. 119 (2016) 27-41]
Biochem Pharmacol. 2024 Mar 20;223:116105. doi: 10.1016/j.bcp.2024.116105. Online ahead of print.NO ABSTRACTPMID:38513506 | DOI:10.1016/j.bcp.2024.116105 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Daniela Impellizzeri Rosanna Di Paola Marika Cordaro Enrico Gugliandolo Giovanna Casili Valeria Maria Morittu Domenico Britti Emanuela Esposito Salvatore Cuzzocrea Source Type: research
Corrigendum to "Involvement of p38 < sup > MAPK < /sup > on the antinociceptive action of myricitrin in mice" [Biochem. Pharmacol. 74 (2007) 924-931]
Biochem Pharmacol. 2024 Mar 20;223:116131. doi: 10.1016/j.bcp.2024.116131. Online ahead of print.NO ABSTRACTPMID:38513507 | DOI:10.1016/j.bcp.2024.116131 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Flavia Carla Meotti Tha ís Posser Fabiana Cristina Missau Moacir Geraldo Pizzolatti Rodrigo Bainy Leal Adair R S Santos Source Type: research
Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin
Biochem Pharmacol. 2024 Mar 19:116140. doi: 10.1016/j.bcp.2024.116140. Online ahead of print.ABSTRACTCancer cells consume more glucose and usually overexpress glucose transporters which have become potential targets for the development of anticancer drugs. It has been demonstrated that selective SGLT2 inhibitors, such as canagliflozin and dapagliflozin, display anticancer activity. Here we demonstrated that canagliflozin and dapagliflozin synergistically enhanced the growth inhibitory effect of paclitaxel in cancer cells including ovarian cancer and oral squamous cell carcinoma cells. Canagliflozin also inhibited glucose u...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Haoning Huang Fan-Lu Kung Yu-Wen Huang Chun-Chien Hsu Jih-Hwa Guh Lih-Ching Hsu Source Type: research
Targeting non-coding RNAs and N < sup > 6 < /sup > -methyladenosine modification in hepatocellular carcinoma
Biochem Pharmacol. 2024 Mar 19:116153. doi: 10.1016/j.bcp.2024.116153. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC), the most common form of primary liver cancers, accounts for a significant portion of cancer-related death globally. However, the molecular mechanisms driving the onset and progression of HCC are still not fully understood. Emerging evidence has indicated that non-protein-coding regions of genomes could give rise to transcripts, termed non-coding RNA (ncRNA), forming novel functional driving force for aberrant cellular activity. Over the past decades, overwhelming evidence has denoted involvem...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Lin Wu Yingmei Zhang Jun Ren Source Type: research
Wnt signaling: Modulating tumor-associated macrophages and related immunotherapeutic insights
Biochem Pharmacol. 2024 Mar 19:116154. doi: 10.1016/j.bcp.2024.116154. Online ahead of print.ABSTRACTWnt signaling pathways are highly conserved cascades that mediate multiple biological processes through canonical or noncanonical pathways, from embryonic development to tissue maintenance, but they also contribute to the pathogenesis of numerous cancers. Recent studies have revealed that Wnt signaling pathways critically control the interplay between cancer cells and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) and potentially impact the efficacy of cancer immunotherapy. In this review, we summar...
Source: Biochemical Pharmacology - March 21, 2024 Category: Drugs & Pharmacology Authors: Yimeng Yuan Dapeng Wu Yifan Hou Yi Zhang Cong Tan Xiaobo Nie Zhenhua Zhao Junqing Hou Source Type: research
Empagliflozin reduces the adverse effects of diabetes mellitus on testicular tissue in type 2 diabetic Rats: A stereological and biochemical study
Biochem Pharmacol. 2024 Mar 18:116135. doi: 10.1016/j.bcp.2024.116135. Online ahead of print.ABSTRACTEmpagliflozin as an antioxidant decreases blood glucose and insulin resistance in type 2 diabetes mellitus. Base on the empagliflozin antioxidant properties we decided to investigate the its effects on the testis histological changes through stereological techniques and biochemical evaluations in T2 diabetes mellitus rats. Rats were divided into: control, diabetes mellitus (DM, streptozotocin + nicotinamide) and diabetes mellitus + empagliflozin (DM + EMPA, 10 mg/kg/day) groups. 56 days after inducing diabetes mellitus test...
Source: Biochemical Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Mina Kiani Malek Soleimani Mehranjani Mohammad Ali Shariatzadeh Source Type: research
Dbl family RhoGEFs in cancer: Different roles and targeting strategies
Biochem Pharmacol. 2024 Mar 16:116141. doi: 10.1016/j.bcp.2024.116141. Online ahead of print.ABSTRACTSmall Ras homologous guanosine triphosphatase (Rho GTPase) family proteins are highly associated with tumorigenesis and development. As intrinsic exchange activity regulators of Rho GTPases, Rho guanine nucleotide exchange factors (RhoGEFs) have been demonstrated to be closely involved in tumor development and received increasing attention. They mainly contain two families: the diffuse B-cell lymphoma (Dbl) family and the dedicator of cytokinesis (Dock) family. More and more emphasis has been paid to the Dbl family members ...
Source: Biochemical Pharmacology - March 18, 2024 Category: Drugs & Pharmacology Authors: Xin-Yi Chen Ao-Yu Cheng Zi-Ying Wang Jin-Mei Jin Jia-Yi Lin Bei Wang Ying-Yun Guan Hao Zhang Yi-Xin Jiang Xin Luan Li-Jun Zhang Source Type: research
