Translational research in head and neck cancer: Molecular and immunological updates
Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis. Each year, approximately 880,000 patients are newly diagnosed with HNSCC worldwide, and 450,000 patients with HNSCC die. Risk factors for developing HNSCC have been identified, with cigarette smoking, alcohol consumption, and viral infections being the major factors. Owing to the prevalence of human papillomavirus infection, the number of HNSCC cases is increasing considerably. Surgery and chemoradiotherapy are the primary treatments for HNSCC. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 27, 2023 Category: ENT & OMF Authors: Takumi Kumai, Hirotaka Shinomiya, Hirofumi Shibata, Hideaki Takahashi, Toshihiro Kishikawa, Ryuhei Okada, Shigeharu Fujieda, Masafumi Sakashita Source Type: research
HDR syndrome, detected in the neonatal period by newborn hearing screening
We report a case of HDR syndrome whose congenital hearing loss was detected by newborn hearing screening (NHS) using AABR. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 27, 2023 Category: ENT & OMF Authors: Shunsuke Takai, Mika Adachi, Hiyori Takahashi, Masayuki Shirakura, Yohei Honkura, Daisuke Yamauchi, Yukio Katori Tags: Case Report Source Type: research
Superior canal dehiscence syndrome: A review
Superior canal dehiscence syndrome (SCDS) is a vestibular disorder in which the presence of a pathological third window in the labyrinth causes several vestibular and cochlear symptoms. Herein, we review the diagnostic criteria and treatment of SCDS. The cause of SCDS is considered to be congenital or acquired; however, its etiology is not well known. Symptoms: Vertigo and/or oscillopsia induced by loud sounds (Tullio phenomenon) or stimuli that change the middle ear or intracranial pressure (fistula symptoms) with vestibular symptoms and hyperacusis and aural fullness with cochlear symptoms are characteristic clinical com...
Source: Auris, Nasus, Larynx - August 26, 2023 Category: ENT & OMF Authors: Mitsuya Suzuki, Yasushi Ota, Taro Takanami, Ryosuke Yoshino, Hiroaki Masuda Source Type: research
Assessment of eosinophilic rhinosinusitis cases that required secondary treatment (biologics or reoperation) during long-term postoperative courses
Endoscopic sinus surgery (ESS) is selected as the primary treatment for eosinophilic chronic rhinosinusitis (ECRS). Biologics or reoperation are sometimes required as secondary treatment after ESS. The present study examined the long-term postoperative courses of ECRS cases treated according to the current treatment concept, the frequency of secondary treatment, and its predictive factors. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 25, 2023 Category: ENT & OMF Authors: Kosuke Akiyama, Yasushi Samukawa, Hiroshi Hoshikawa Tags: Original Article Source Type: research
Evaluation of odor recognition threshold measurement methods in T & T olfactometry: A survey study
This study aimed to clarify the correct odor expressions and use of the olfactory term table. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 11, 2023 Category: ENT & OMF Authors: Kei Hosoya, Taro Komachi, Yohei Maeda, Hitoshi Akazawa, Eriko Ogino, Azusa Yoshida, Kimihiro Okubo, Takaki Miwa Tags: Original Article Source Type: research
The current findings in eosinophilic chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of the nasal cavity and paranasal sinuses. Traditional classification is denoted by the presence (CRSwNP) or absence of nasal polyps (CRSsNP). Particularly, CRSwNP is distinguished by the presence of infiltrating cells and inflammatory markers in the nasal mucosa. Patients with CRSwNP in Western countries predominantly display a type 2 endotype, whereas those in Asian regions display a mixed type 2 endotype. Nevertheless, recent transcriptome analyses have revealed two types of nasal polyps - type 2 and non-type 2 polyps, suggesting that geographical differe...
Source: Auris, Nasus, Larynx - August 11, 2023 Category: ENT & OMF Authors: Takeshi Tsuda, Masanobu Suzuki, Yukinori Kato, Masanori Kidoguchi, Takumi Kumai, Shigeharu Fujieda, Masafumi Sakashita Source Type: research
Cochlear implantation for progressive hearing loss caused by an A8296G mutation in mitochondrial DNA
This report presents the case of a patient with the A8296G mutation and severe bilateral sensorineural hearing loss (SNHL) that progressed over two decades. The patient had no history of diabetes, but did have a family history of SNHL in her father and maternal grandmother. She was first diagnosed with SNHL at 45 years of age, and an A8296G mutation was found. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 10, 2023 Category: ENT & OMF Authors: Toshihito Sahara, Akinori Kashio, Teru Kamogashira, Erika Ogata, Yusuke Akamatsu, Tatsuya Yamasoba Tags: Case Report Source Type: research
Tracheostomy in otorhinolaryngology education and training programs: A Japanese nationwide survey
Surgical airway management is one of the most effective techniques for safe airway management. Within the training programs relating to knowledge and skills required by otorhinolaryngologists, tracheostomy and postoperative management are important items that must be fully understood by airway surgeons. We performed a nationwide survey to identify problems within tracheostomy and postoperative management in Japan in order to establish practical and safe guidelines for surgical airway management. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 8, 2023 Category: ENT & OMF Authors: Masaaki Higashino, Koichiro Saito, Kiyoaki Tsukahara, Masamitsu Hyodo, Hideki Hirabayashi, Ryo Kawata Tags: Original Article Source Type: research
Enhanced recovery pathways for head and neck surgery with free tissue transfer reconstruction
The enhanced recovery after surgery (ERAS) pathway is designed to facilitate recovery after surgery by packaging evidence-based protocols specific to each aspect of the perioperative period, including the preoperative, intraoperative, postoperative, and post-discharge periods. The ERAS pathway, which was originally developed for use with colonic resection, is now being expanded to include a variety of surgical procedures, and the ERAS Society has published a consensus review of the ERAS pathway for head and neck surgery with free tissue transfer reconstruction (HNS-FTTR). (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 7, 2023 Category: ENT & OMF Authors: Takayuki Imai, Yukinori Asada, Kazuto Matsuura Source Type: research
Triple endoscopy and recurrent croup in children: A single aerodigestive center experience
To determine the utility of triple endoscopy (combined direct laryngoscopy, bronchoscopy (DLB), flexible bronchoscopy with bronchoalveolar lavage (FB + BAL), and esophagogastroduodenoscopy (EGD)) in the diagnosis and management of patients with recurrent croup (RC), and to identify predictors of endoscopic findings (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 5, 2023 Category: ENT & OMF Authors: Jennifer P. Vu, Deepak Jagannath, David R. Spielberg, Eric H. Chiou, Kathleen E. Hosek, Elton M. Lambert Tags: Original Article Source Type: research
Endoscopic balloon dilatation in the management of paediatric-acquired subglottic stenosis in children
To summarise our experience and the outcomes of endoscopic balloon dilatation (EBD) in the management of paediatric-acquired subglottic stenosis (SGS), and to further explore the influencing factors of successful EBD. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - August 4, 2023 Category: ENT & OMF Authors: Lanye Hu, Ning He, Shan He, Yu Jiao Tags: Original Article Source Type: research
Application of phosphorylcholine derivative as mucosal adjuvant enhancing mucosal immune responses in the upper respiratory tract
A phosphorylcholine (PC)-derivative with high binding ability (PCDB) was intranasally administered to mice with ovalbumin (OVA), and immune responses were investigated to determine whether PCDB has antigenicity and adjuvanticity. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - July 31, 2023 Category: ENT & OMF Authors: Tomohiro Jimura, Yuichi Kurono, Takashi Hirano, Masaki Kawabata, Masaru Yamashita Tags: Original Article Source Type: research
Long-term effects of second cochlear implantation with sequential bilateral cochlear implantation in Japanese children
This study aimed to longitudinally evaluate speech perception ability and sound-field thresholds with the first, second, or bilateral cochlear implants (CIs) and MAP parameters of second CI in children. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - July 24, 2023 Category: ENT & OMF Authors: Naoe Mori, Norio Yamamoto, Shinobu Yamaguchi, Kanako Kondo, Misaki Yoshizawa, Takayuki Okano, Juichi Ito, Koichi Omori Tags: Original Article Source Type: research
Tumor localization is the important factor for recovery time of postoperative facial nerve paralysis in benign parotid surgery
This study aimed to examine the progress of recovery from postoperative transient facial nerve paralysis (POFNP). (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - July 21, 2023 Category: ENT & OMF Authors: Ichita Kinoshita, Ryo Kawata, Masaaki Higashino, Tetsuya Terada, Shin-Ichi Haginomori, Takeshi Tochizawa Tags: Original Article Source Type: research
Summary of Japanese clinical practice guidelines for head and neck cancer - 2022 update edited by the Japan society for head and neck cancer
The aim of the “Japanese Clinical Practice Guidelines for Head and Neck Cancer - 2022 Update” is to review the latest evidence regarding head and neck cancer and to present the current standard approaches for diagnosis and treatment. These evidence-based recommendations were created with the consensus of the G uideline Committee, which is composed of otorhinolaryngologists and head and neck surgeons, together with radiologists, radiation oncologists, medical oncologists, plastic surgeons, dentists, palliative care physicians, and rehabilitation physicians. (Source: Auris, Nasus, Larynx)
Source: Auris, Nasus, Larynx - July 21, 2023 Category: ENT & OMF Authors: Akihiro Homma, Mizuo Ando, Nobuhiro Hanai, Hiroyuki Harada, Yoshitaka Honma, Tomonori Kanda, Satoshi kano, Daisuke Kawakita, Naomi Kiyota, Yoshiyuki Kizawa, Masahiro Nakagawa, Takenori Ogawa, Hirotaka Shinomiya, Takeshi Shinozaki, Motoyuki Suzuki, Tetsuya Source Type: research
