Population-based screening methods in biliary atresia: a systematic review and meta-analysis
Conclusion
Conjugated bilirubin measurements and SCC are the most researched and demonstrate improved sensitivity and specificity in detecting BA. However, their use is expensive. Further research into conjugated bilirubin measurements, as well as alternative methods of population-based BA screening, is required.
PROSPERO registration number
CRD42021235133. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Arshad, A., Gardiner, J., Ho, C., Rees, P., Chadda, K., Baker, A., Sutcliffe, A. G. Tags: Editor's choice Original research Source Type: research
Ten-year survival of children with trisomy 13 or trisomy 18: a multi-registry European cohort study
Conclusions
This multi-registry European study found that despite extremely high neonatal mortality in children with T13 and T18, 32% and 21%, respectively, of those who survived to 4 weeks were likely to survive to age 10 years. These reliable survival estimates are useful to inform counselling of parents after prenatal diagnosis. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Glinianaia, S. V., Rankin, J., Tan, J., Loane, M., Garne, E., Cavero-Carbonell, C., de Walle, H. E. K., Gatt, M., Gissler, M., Klungsoyr, K., Lelong, N., Neville, A., Pierini, A., Tucker, D. F., Urhoj, S. K., Wellesley, D. G., Morris, J. K. Tags: Original research Source Type: research
High-flow oxygen therapy in moderate to severe bronchiolitis: a randomised controlled trial
Conclusion
We found no measurable clinically relevant benefit in the use of HF compared with LF in hypoxic children with moderate to severe bronchiolitis.
Trial registration number
NCT02913040. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Kooiman, L., Blankespoor, F., Hofman, R., Kamps, A., Gorissen, M., Vaessen-Verberne, A., Heuts, I., Bekhof, J. Tags: Original research Source Type: research
Ethnicity, child health and paediatric services
Introduction Paediatricians have a moral obligation to promote the health and well-being of all children. To achieve this, unmet health needs of minoritised ethnic groups must be addressed. Language for describing disadvantaged ethnic groups is evolving. The term ‘minoritised’ is useful in this context, acknowledging active processes at play and that this can occur to majority groups.1 In this article, we describe the role of paediatricians in addressing ethnic health disparities. Health disparities Infant mortality rate (IMR) is a key indicator of health inequity. In 2019, the IMR in England and Wales was 2.6 ...
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Qureshi, Z., Richards, A., Kingdon, C. C., Sinha, I., Lokulo-Sodipe, O., Rose, A. M. Tags: Viewpoint Source Type: research
Immunomodulatory therapy in dengue: need for clinical trials and evidence base
Dengue infection is a major public health problem especially in the Southeast Asian region (SEAR). The incidence of dengue is estimated at 390 million infections with a prevalence of 3.9 billion worldwide. Notably, the mortality due to severe dengue is 15.9 times higher in children under 14 years of age.1 Infections such as dengue, tuberculosis and malaria remain a bigger challenge for children in low/middle-income countries (LMICs) but unlike infection with SARS-CoV-2 have not attracted global attention and continue to be neglected. More children died of dengue in the last 2 years than from COVID-19.1 Vaccines and antivir...
Source: Archives of Disease in Childhood - May 18, 2023 Category: Pediatrics Authors: Bhat, C. S., Shetty, R., Sundaram, B., Ramanan, A. V. Tags: COVID-19 Viewpoint Source Type: research
