Highlights from the literature
More treatment for obesity These are adult data but worthwhile reading. Tirzepatide, which is used in type two diabetes and is an insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist has not been examined in obese adults without diabetes. It is a once-a-week subcutaneous delivered medication. Jastreboff AM et al [N Engl J Med 2022; 387:205–216 DOI: 10.1056/NEJMoa2206038] have completed a phase three double-blind, randomised, controlled trial in 2539 adults with a body-mass index of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes over 72 weeks. They have lo...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Tags: Miscellanea Source Type: research
Are Britains rivers safe for family recreational activities in 2023?
We have fond memories of spending our family summers playing in British rivers. However, the Environmental Agency (EA) highlights alarmingly frequent and prolonged discharges of untreated sewage into our rivers, through storm overflow spills1—averaging 825 spills each day, totalling nearly 1.8 million hours over 2022. Concerns must be raised whether all of these releases are necessary, and why none of our rivers now meet legal water quality standards. Clean water and sanitation is one of the most important modern public health interventions. As human excrement contains over 50 pathogens,2 the accidental ingestion of ...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Philip, E., Finlay, F., Talbot, J. Tags: PostScript Source Type: research
Socioeconomic barriers preventing children and young people living with long-term health conditions from achieving optimal outcomes
Children and young people living with a chronic illness (CI) and faced with poverty are less likely to benefit from medical advances than their more affluent peers.1–3 Clinical outcomes are poorer,1–4 setting these children on a trajectory of lifelong disadvantage. Inequality may be due to a variety of factors: some require action at a political level, while others could be addressed closer to home. In the Liverpool City Region, more than 80 000 children and young people are growing up in poverty. We undertook a scoping exercise in collaboration with Health Junction, an independent, not-for-profit community int...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Blair, J. C., Aitken, C., Smith, J., Ghatak, A., Jones, C. A., Thursfield, R., Oni, L. Tags: PostScript Source Type: research
Access to evidence-based treatments for young people with body dysmorphic disorder
Introduction Body dysmorphic disorder (BDD) typically emerges during adolescence, affects approximately 2% of the general population and is highly impairing. Despite its prevalence and impact, awareness of BDD remains poor and the condition often goes undiagnosed and untreated.1 Cognitive–behavioural therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are effective treatments for BDD and recommended as the first-line interventions.2 However, little is known about the accessibility of these treatments within the UK or among young people specifically. We conducted a case note review to examine the treatme...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Krebs, G., Rifkin-Zybutz, R., Clark, B., Jassi, A. Tags: PostScript Source Type: research
The SCOUT study finally arrives
This study started recruiting in 2012 from two children’s hospital in Philadelphia and Pittsburgh and it took 7 years to recruit. Congratulations to the researchers. It illustrates, that to deliver a rigourous well managed, randomised controlled trial in children with a common clinical problem, it takes time and commitment. Zaoutis T et al (JAMA Pediatr doi:10.1001/jamapediatrics.2023.1979) have tackled the topic of antibiotic treatment for uncomplicated urinary tract infection (UTI) in children. How long should we treat for? They have compared the efficacy of standard-course (10 days) and short-course therapy (5 day...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Tags: Miscellanea Source Type: research
Quality of life of children and young people with anterior chest wall deformity: a systematic review of the literature
Conclusions
Correction of ACWD is associated with significant improvement in the psychosocial QoL of children and young people. Further work is required to standardise QoL data collection for all children with ACWD to achieve a greater understanding of the impact and guide future management. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Johnstone, A. D., Davis, C., Roberts, N. J., Sharp, K. Tags: Original research Source Type: research
Effectiveness of asthma preventer dispensing for preventing childhood asthma readmissions: a multisite cohort linkage study
Conclusions
There was a low rate for prescribing and dispensing of hospital discharge asthma preventers and no protective effect was found for its impact on readmissions. A protective effect on readmissions was found for community asthma preventer dispensing. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Chen, K. Y.-H., Aye Tun, N., Jones, R., Shanthikumar, S., Carlin, J. B., Hiscock, H. Tags: Original research Source Type: research
Association between breastfeeding duration and educational achievement in England: results from the Millennium Cohort Study
Conclusions
A longer breastfeeding duration was associated with modest improvements in educational outcomes at age 16, after controlling for important confounders. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Pereyra-Elias, R., Carson, C., Quigley, M. A. Tags: Open access, Press releases Original research Source Type: research
Assessing maternal alcohol consumption in pregnancy: comparison of confidential postnatal maternal interview and measurement of alcohol biomarkers in meconium
Conclusions
FAEEs and EtG measured in meconium have low sensitivity and specificity for self-reported alcohol consumption after 20 weeks’ gestation in an unselected Scottish population. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Henderson, E. M., Tappin, D., Young, D., Favretto, D., Mactier, H. Tags: Original research Source Type: research
Navigating the unknown: understanding and managing parental anxiety when a child is ill
Conclusions
Although parents make carefully considered decisions on whether or not to consult a doctor, many appear to miss red flags, including more experienced parents. Conversely, some become overly concerned with certain specific symptoms such as fever, and few parents are familiar with self-management strategies. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Simoens, E., Michiels, L., Toelen, J., de Winter, P. Tags: Original research Source Type: research
Association between maternal influenza vaccination and neurodevelopmental disorders in childhood: a longitudinal, population-based linked cohort study
Conclusions
We did not observe increased risk of neurodevelopmental disorders following in utero exposure to seasonal IIV. Although we observed some evidence for lower risk of seizure and sleep disorders, additional studies are required to confirm. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Foo, D., Sarna, M., Pereira, G., Moore, H. C., Regan, A. K. Tags: Open access Original research Source Type: research
Assessment of parental decision making in congenital heart disease, cardiomyopathy and heart transplantation: an observational study analysing decisional characteristics and preferences
Conclusion
Although factors may alter the weight of influence on DM, most parents desire equal parental and medical team influence on DM. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Tadros, H. J., Saidi, A., Rawlinson, A. R., Cattier, C., Black, E. W., Rackley, J., Breault, L., Pietra, B. A., Fricker, F. J., Gupta, D. Tags: Original research Source Type: research
Pachydermodactyly
A 15-year-old boy presented with swelling in his fingers, which had developed over 3 years. He had no history of trauma, pain and fever or morning stiffness. He was right-handed, with anxiety issues and also had repetitive finger friction behaviour. On examination, soft tissue swelling and skin thickening were observed in the lateral of the bilateral second to fourth proximal interphalangeal (PIP) joints bilaterally and left-hand second distal interphalangeal joints (figure 1). Complete blood counts, biochemistry and inflammatory marker levels were normal. Antinuclear antibody, rheumatoid factor and cyclic citrullinated pe...
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Yüksel, S., Kılbas, G., Ayduran, S., Comut, E. Tags: Miscellanea Source Type: research
Are children with prolonged fever at a higher risk for serious illness? A prospective observational study
Conclusion
Children with prolonged fever have a higher risk of SBI, warranting a careful clinical assessment and diagnostic workup. Warning signs of SBI occurred infrequently but, if present, increased the likelihood of SBI. Although rare, clinicians should consider important non-infectious causes of prolonged fever. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Nijman, R. G., Tan, C. D., Hagedoorn, N. N., Nieboer, D., Herberg, J. A., Balode, A., von Both, U., Carrol, E. D., Eleftheriou, I., Emonts, M., van der Flier, M., de Groot, R., Kohlmaier, B., Lim, E., Martinon-Torres, F., Pokorn, M., Strle, F., Tsolia, M. Tags: Editor's choice, ADC Paediatric Emergency Medicine Source Type: research
Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First maternal preconception nutrition randomised controlled trial
Conclusions
Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ24 predicted ECD. Interventions addressing multiple components of the nurturing care model may offer greatest impact on children’s developmental potential.
Trial registration number
NCT01883193. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2023 Category: Pediatrics Authors: Fernandes, M., Krebs, N. F., Westcott, J., Tshefu, A., Lokangaka, A., Bauserman, M., Garces, A. L., Figueroa, L., Saleem, S., Aziz, S. A., Goldenberg, R. L., Goudar, S. S., Dhaded, S. M., Derman, R. J., Kemp, J. F., Koso-Thomas, M., Sridhar, A., M McClure Tags: Open access, ADC Global child health Source Type: research
