Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study
Conclusions
CNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Anastasopoulou, S., Svensson, E., Wickström, R., Hertting, O., Rinder, M. R., Bennet, R., Eriksson, M. Tags: Open access, COVID-19 Original research Source Type: research
Long-term outcomes of an educational paediatric antimicrobial stewardship programme: a quality improvement study
Conclusions
Intensification of counselling educational activities within an ASP suggests to improve QOP and to partially reduce AMC in paediatric patients. The decreasing trends in mortality remained unchanged. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Aboza Garcia, M., Goycochea-Valdivia, W., Penalva, G., Falcon Neyra, L., Moleon Ruiz, M., Rodriguez-Villodres, A., Montero Valladares, C., Olbrich, P., Sanchez-Valderrabanos, E., Jimenez, F., Molina, M., Moreno Madueno, G., Valencia Martin, R., Gil Navarr Tags: Original research Source Type: research
Eosinophilic oesophagitis - have we caused it?
Over the last decade, the incidence of eosinophilic oesophagitis (EoE) appears to have increased. In genetically predisposed individuals, the evidence seems to suggest an early life exposure or event that has initiated this lower oesophageal morbidity. What factors could contribute to this? Jensen at al (JAMA Pediatr. 2023;177:1285–1293. doi:10.1001/jamapediatrics.2023.4609) have examined the association between antibiotic use in pregnancy and in early infancy and the role of acid suppressants during infancy. This was a large case-controlled study from Scandinavia and included 392 cases of EoE with comparison to 3637...
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research
Group-based parent training programme for children with neurological conditions: a feasibility study
Conclusions
The group parenting intervention for parents of children with heterogeneous neurological conditions and behaviours that challenge appears feasible and effective in improving child behaviour and parental well-being. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Parikh, N., Faulkner, A., Hadji-Michael, M., Heyman, I., Murphy, T., McAllister, E. Tags: Original research Source Type: research
Importance of parental involvement in paediatric palliative care in Hong Kong: qualitative case study
Conclusions
This original study identified the importance of palliative care with active engagement of parents which can address the service gap for CLLC. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Wong, F. K. Y., Ho, J. M. C., Lai, T. C., Lee, L. P. Y., Ho, E. K. Y., Lee, S. W. Y., Chan, S. C. W., Fung, C. W., Ho, A. C. H., Li, C.-H., Li, C. K., Chiu, A. T. G., Tsui, K. W., Lam, K. K. W. Tags: Original research Source Type: research
Infant fat mass and later child and adolescent health outcomes: a systematic review
Conclusions
Current evidence, from a small number of studies, suggests a positive association between infant adiposity and future adiposity or BMI, but the validity of infant body composition as a biomarker of future health remains inconclusive. Carefully designed, standardised studies are required to identify the value of infant body composition for predicting later health.
Trial registration
PROSPERO: 288013 (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Amati, F., McCann, L., Castaneda-Gutierrez, E., Prior, E., van Loo-Bouwman, C. A., Abrahamse-Berkeveld, M., Oliveros, E., Ozanne, S., Symonds, M. E., Chang, C.-Y., Modi, N. Tags: Open access Original research Source Type: research
Xylitol for the prevention of acute otitis media episodes in children aged 1-5 years: a randomised controlled trial
Conclusions
Regular use of xylitol did not prevent AOM, URTIs or dental caries in a trial with limited statistical power. A post-hoc analysis indicated that URTIs were less common with xylitol exposure during the COVID-19 pandemic, but this finding could be spurious.
Trial registration number
NCT03055091. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Persaud, N., Azarpazhooh, A., Keown-Stoneman, C., Birken, C. S., Isaranuwatchai, W., Maguire, J. L., Mamdani, M., Allen, C., Mason, D., Kowal, C., Jaleel, M., Bazeghi, F., Thorpe, K. E., Laupacis, A., Parkin, P. C. Tags: Open access Original research Source Type: research
Clinical presentation of childhood soft tissue sarcomas: a systematic review and meta-analysis
Conclusions
For STS, pre-diagnostic symptoms differ by age and location, highlighting the need to tailor early diagnosis interventions. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Ni Cheallaigh, L., Liu, J.-F., Fern, L., Winyard, P., Walker, D., Ball-Gamble, A., Shanmugavadivel, D. Tags: Original research Source Type: research
Prevalence of neural tube defects in England prior to the mandatory fortification of non-wholemeal wheat flour with folic acid: a population-based cohort study
Conclusions
Baseline NTD prevalence for England has been established. National and standardised CA registration is in place, facilitating the systematic and consistent monitoring of pre-fortification and post-fortification NTD trends and evaluating the impact of fortification on NTD prevalence. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Broughan, J. M., Martin, D., Higgins, T., Swan, G., Cullum, A., Kurinczuk, J. J., Draper, E. S., Luyt, K., Wellesley, D. G., Stevens, S., Tedstone, A., Rankin, J. Tags: Open access, Editor's choice Original research Source Type: research
BANDIT study: preserving {beta}-cell function in recently diagnosed type 1 diabetes
Janus kinase inhibitors (JAKi) are effective disease-modifying treatments for autoimmune diseases such as juvenile idiopathic arthritis, alopecia and eczema. JAK are cytoplasmic non-receptor tyrosine kinases involved in chronic inflammation. There are four recognised members (JAK1, JAK2, JAK3 and TYK2) and they act by transducing cytokine signalling which in turn regulates several genes involved with inflammation. Tofacitinib, abrocitinib, baricitinib, upadacitinib and filgotinib are the most common JAKi available. Some are administered intravenously but baricitinib is taken orally. Waibel M et al (N Engl J Med 2023;389:21...
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research
Acute splenic sequestration in HbSS: observations from the Jamaican birth cohort
Conclusions
ASS remains an important cause of morbidity and mortality in HbSS in developing societies. ASS appears to be a non-specific response to many possible risk factors including coagulase negative staphylococci. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Serjeant, G., Mason, K., Hambleton, I., Serjeant, B. Tags: ADC Global child health Source Type: research
Towards an international consensus on safety netting advice for acutely ill children presenting to ambulatory care: a modified e-Delphi procedure
Conclusions
SNA needs to contain advice on the expected disease course, alarm signs and where and how to find help. It should be given verbally with written resources by a reliable healthcare professional or digital platform. Short, simple and specific, SNA needs to empower the parent whose understanding of the advice should be checked. The effectiveness of SNA resources coproduced by parents and experts should be assessed in different settings and those providing SNA require up-to-date and reliable training. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Burvenich, R., Heytens, S., De Sutter, A., Struyf, T., Toelen, J., Verbakel, J. Y. Tags: Paediatric Emergency Medicine Source Type: research
Procedural sedation programme minimising adverse events: a 3-year experience from a tertiary paediatric emergency department
Conclusion
This study presents a large single-centre dataset on the use of intravenous ketamine in paediatric procedural sedation. Adhering to international standards and benchmarks for provider skills and training, drug administration and monitoring facilities, with a strict clinical governance process, optimizes patient safety. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Erumbala, G., Anzar, S., Deiratany, S., Blackie, B., Powell, C., Al Ansari, K. Tags: Paediatric Emergency Medicine Source Type: research
External second opinions: building trust between health professionals and families
In medicine, external second opinions are frequently sought to inform decisions around a patient’s proposed course of treatment. However, they are also sought in more challenging circumstances such as when disagreement arises between the healthcare team and the family, or during complex end-of-life discussions in critically ill children. When done well, external second opinions can help build trust and reduce conflict. However, when done poorly they may antagonise relationships and thwart attempts to bring about consensus. While principles of good medical practice should always be followed, the actual second opinion ...
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Fraser, J., Goold, I., Akindolie, O., Linney, M. Tags: Review Source Type: research
How can we best chart childrens growth in the paperless age? The UK experience
This article describes the key issues to consider in planning this transition and the charting options available, ranging from bespoke local systems to commercial packages and a new initiative by the Royal College of Paediatrics and Child Health. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - January 22, 2024 Category: Pediatrics Authors: Wright, C. M., Chapman, S., Cole, T. J. Tags: Review Source Type: research
