Sweat conductivity diagnostic accuracy for cystic fibrosis: a systematic review and meta-analysis
Conclusion
SC demonstrated excellent diagnostic performance. In addition, its accuracy parameters suggest its role as an alternative to the sweat test for CF diagnosis.
PROSPERO registration number
CRD42022284504. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Zhang, L., Nomiyama, S., Bedran, R. M., Alvim, C. G., Ribeiro, J. D., Camargos, P. Tags: Original research Source Type: research
Improved paediatric antimicrobial prescribing with a smartphone application: a before and after interventional study
Conclusion
There was a significant and sustained improvement in adherence to paediatric antimicrobial guidelines following the introduction of a prescribing support app. The need to seek guidance for antimicrobial doses due to the age-based and weight-based calculations in paediatrics may mean that AMS interventions such as decision support and prescribing tools are particularly well suited to paediatric prescribing. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Primhak, S., Pool, N., Sam, M. S. Y., Duffy, E., Ritchie, S. R., Webb, R., Wilson, E., Voss, L., Best, E. J. Tags: Original research Source Type: research
Paediatricians can reduce future alcohol-related morbidity and mortality
In the UK, the legal drinking age at home is 5 years, and a significant proportion of parents here and in other European countries allow and even encourage their young adolescents to drink alcohol, believing that it will teach them responsible use or inoculate them against harmful drinking and dependency. The attitudes, practices and policies regarding alcohol initiation and consumption by children and parents across the world today may contribute to a broad range of negative health outcomes throughout a child’s lifespan, much of which are preventable, starting from childhood.1 Neuroadaptations, neoplastic transforma...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Sigman, A. Tags: Press releases Viewpoint Source Type: research
Stillbirths and neonatal deaths: a neglected global pandemic
Introduction The SARS-CoV-2 pandemic has attracted unprecedented attention within the global health (GH) community, the public and in politics worldwide, overshadowing numerous, long-existing major threats to GH (box 1). While resembling several other pandemics, it is perceived and portrayed as an ultimate threat to GH and security. This view is promoted mainly by high-income countries (HICs),1 but ignores the long-existing challenges especially those affecting children, namely climate change, poverty and hunger.2 3 Box 1Major threats to global health* Climate change, environmental degradation, exploitation of natural reso...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Krüger, C. Tags: COVID-19 Viewpoint Source Type: research
Outcomes of neonatal critical congenital heart disease: results of a prospective registry-based study from South India
Conclusions
While systematic screening, especially pulse oximetry screening, enabled early identification and prompt management of a significant proportion of neonates with critical CHD, important health system challenges like low use of prostaglandin need to be overcome to minimise preoperative mortality. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Sasikumar, D., Prabhu, M. A., Kurup, R., Francis, E., Kumar, S., Gangadharan, S. T., Mahadevan, K. K., Sivasankaran, S., Kumar, R. K. Tags: ADC Global child health Source Type: research
Development of clinical-based scoring system to diagnose tuberculous meningitis in children
Conclusion
The clinical scoring system consisting of systemic and neurological features can be used to predict the diagnosis of TBM in children with limited resource setting. The scoring system should be assessed in a prospective cohort. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Handryastuti, S., Latifah, D., Bermanshah, E. K., Gunardi, H., Kadim, M., Iskandar, R. A. T. P. Tags: Open access, ADC Global child health Source Type: research
Haemoptysis: is it really from the lungs? The well child who spits out blood
This article discusses the differential diagnosis and appropriate investigations. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Balfour-Lynn, I. M. Tags: Review Source Type: research
Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance
Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands. This can be a primary adrenal disorder or secondary to adrenocorticotropic hormone deficiency or suppression from exogenous glucocorticoids. Symptoms of AI in children may initially be non-specific and include growth faltering, lethargy, poor feeding, weight loss, abdominal pain, vomiting and lingering illnesses. AI is treated with replacement doses of hydrocortisone. At times of physiological stress such as illness, trauma or surgery, there is an increased requirement for exogenous glucocorticoids, which if untreated can le...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Mushtaq, T., Ali, S. R., Boulos, N., Boyle, R., Cheetham, T., Davies, J. H., Elder, C. J., Gan, H.-W., Hindmarsh, P. C., Katugampola, H., Krone, N., Salomon Estebanez, M., Shenoy, S., Tollerfield, S., Wong, S. C., Regan, F., Developed by the Paediatric Ad Tags: Open access Review Source Type: research
Kawasaki disease sub-groups
Kawasaki’s disease (KD) and Atypical Kawasaki’s disease (AKD) always concerned the Archivist. Many children with fever, lymph nodes and a rash do not have KD and recover fully from their viral illness. Occasionally a diagnosis of KD would be missed and a child would end up with the well-known coronary artery sequelae. Wang H et al (Lancet Child Adolesc Health 2023;7: 697–707. https://doi.org/10.1016/S2352-4642(23)00166-9). have examined 1016 patients with KD and identified four subgroups. They have used a data driven approach to examine the possibility that KD is not a single disease entity. They analysed...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Tags: Miscellanea Source Type: research
Naming of children
It is unusual for the state, through its courts, to interfere with the naming of a child. The reported cases relating to children’s names are not numerous, and almost all refer to changing registered names, rather than challenging a parent’s original choice of name. Hitherto, if required, intervention in parental choice has focused on the surname, often in the context of maintaining a link between a child and their father.1 Courts recognise that given names have a less ‘concrete’ character, whereby nicknames and alternative names become adherent to the maturing child. Judges have previously speculat...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Wheeler, R. Tags: Clinical law for clinical practice Source Type: research
Atoms
Though he’d gained a little weight since the height of his legal sparring prowess, he still had an aura, a charisma which few of his high street rivals could even start to muster, let alone match. He pulled some of the old tricks: the harlequin waistcoat, the ostentatious handkerchief, the textured paper, but no one held these against him. On the contrary, he emanated confidence and his immaculate office (even the paperweight was consistently angled to catch the evening sun) only served to heighten this. His secret? ‘Filing, my friend – it’s all to do with classification’. His cabinet testifie...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Brown, N. Tags: Highlights from this issue Source Type: research
Highlights from the literature
This study was conducted using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Pregnant women and included 50 obstetric clinics and hospitals in Japan [7097 children in this study, 3674 were boys (51.8%) and 3423 were girls (48.2%)]. Screen time was categorised into four categories; 3440 children (48.5%) had less... (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Tags: Miscellanea Source Type: research
Effect on maximal mouth opening in children with spinal muscular atrophy treated with onasemnogene abeparvovec
Spinal muscular atrophy (SMA) is a progressive, autosomal recessive neuromuscular disorder caused by a mutation of the SMN1 gene. This causes progressive muscle weakness and muscle atrophy. The voluntary muscles are affected, including those involved in swallowing and breathing. The muscles of mastication are also affected in them. Adequate mouth opening is required to maintain good oral hygiene and adequate mastication. Tools like maximum tongue pressure and maximum mouth opening (MMO) are often used as clinical and sensitive outcome measures for assessing oral function tests.1 MMO is the maximal interincisal distance on ...
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Authors: Beri, N., Kapoor, L., Parashar, D., Mundada, V. Tags: PostScript Source Type: research
Atoms
Round the bloc(k), again On a first viewing, a briskly walking pedestrian would barely have afforded the past-its-heyday demeanour of the Brownstone a second glance. Just before the intersection of 49th and 57th (you know the spot, the neglected swings on the right just before the lights) the loose rooftop slates only visible to the vertically unchallenged and, not in themselves, anything that might demand a change in pace, a closer look. Had she not been looking for affordable property, a surprise for her fiancé, a first home together for them both (once the wretched thesis and defence on instability in Yugoslavia ...
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Authors: Brown, N. Tags: Highlights from this issue Source Type: research
Towards evidence-based medicine for paediatricians
It’s obvious Those of you reading this section are, most probably, convinced as to the value of skills in question forming, literature searching, critical appraisal and action on evidence. You’re committed, in some degree, to the practice of evidence-based medicine. To you, it’s obvious. If you weren’t you though, it might not be so clear. If you were being forced to do critical appraisal checklists, to recite the litany of potential biases and crunch relative risks and numbers needed to harm because your school, college or postgraduate course demanded it... and particularly if that was a section ta...
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Authors: Phillips, B. Tags: ADC Archimedes Source Type: research
