Metabolomic analysis to understand the mechanism of Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > (MXene) toxicity in Daphnia magna
Aquat Toxicol. 2024 Mar 18;270:106904. doi: 10.1016/j.aquatox.2024.106904. Online ahead of print.ABSTRACTDue to their potential release into the environment, the ecotoxicity of Ti3C2Tx (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti3C2Tx induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti3C2Tx with different sheet sizes (100 nm [Ti3C2Tx-100] and 500 nm [Ti3C2Tx-500]) by employing conventional toxicology and metabolomics analysis. The results...
Source: Aquatic Toxicology - March 21, 2024 Category: Toxicology Authors: Qianqian Xiang Zhujun Wang Jinzhan Yan Minmin Niu Wenyu Long Zhihao Ju Xuexiu Chang Source Type: research
Metabolomic analysis to understand the mechanism of Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > (MXene) toxicity in Daphnia magna
Aquat Toxicol. 2024 Mar 18;270:106904. doi: 10.1016/j.aquatox.2024.106904. Online ahead of print.ABSTRACTDue to their potential release into the environment, the ecotoxicity of Ti3C2Tx (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti3C2Tx induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti3C2Tx with different sheet sizes (100 nm [Ti3C2Tx-100] and 500 nm [Ti3C2Tx-500]) by employing conventional toxicology and metabolomics analysis. The results...
Source: Aquatic Toxicology - March 21, 2024 Category: Toxicology Authors: Qianqian Xiang Zhujun Wang Jinzhan Yan Minmin Niu Wenyu Long Zhihao Ju Xuexiu Chang Source Type: research
Metabolomic analysis to understand the mechanism of Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > (MXene) toxicity in Daphnia magna
Aquat Toxicol. 2024 Mar 18;270:106904. doi: 10.1016/j.aquatox.2024.106904. Online ahead of print.ABSTRACTDue to their potential release into the environment, the ecotoxicity of Ti3C2Tx (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti3C2Tx induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti3C2Tx with different sheet sizes (100 nm [Ti3C2Tx-100] and 500 nm [Ti3C2Tx-500]) by employing conventional toxicology and metabolomics analysis. The results...
Source: Aquatic Toxicology - March 21, 2024 Category: Toxicology Authors: Qianqian Xiang Zhujun Wang Jinzhan Yan Minmin Niu Wenyu Long Zhihao Ju Xuexiu Chang Source Type: research
Metabolomic analysis to understand the mechanism of Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > (MXene) toxicity in Daphnia magna
Aquat Toxicol. 2024 Mar 18;270:106904. doi: 10.1016/j.aquatox.2024.106904. Online ahead of print.ABSTRACTDue to their potential release into the environment, the ecotoxicity of Ti3C2Tx (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti3C2Tx induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti3C2Tx with different sheet sizes (100 nm [Ti3C2Tx-100] and 500 nm [Ti3C2Tx-500]) by employing conventional toxicology and metabolomics analysis. The results...
Source: Aquatic Toxicology - March 21, 2024 Category: Toxicology Authors: Qianqian Xiang Zhujun Wang Jinzhan Yan Minmin Niu Wenyu Long Zhihao Ju Xuexiu Chang Source Type: research
Metabolomic analysis to understand the mechanism of Ti < sub > 3 < /sub > C < sub > 2 < /sub > T < sub > x < /sub > (MXene) toxicity in Daphnia magna
Aquat Toxicol. 2024 Mar 18;270:106904. doi: 10.1016/j.aquatox.2024.106904. Online ahead of print.ABSTRACTDue to their potential release into the environment, the ecotoxicity of Ti3C2Tx (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti3C2Tx induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti3C2Tx with different sheet sizes (100 nm [Ti3C2Tx-100] and 500 nm [Ti3C2Tx-500]) by employing conventional toxicology and metabolomics analysis. The results...
Source: Aquatic Toxicology - March 21, 2024 Category: Toxicology Authors: Qianqian Xiang Zhujun Wang Jinzhan Yan Minmin Niu Wenyu Long Zhihao Ju Xuexiu Chang Source Type: research
Integrated microbiome and metabolome analyses reveal the effects of low pH on intestinal health and homeostasis of crayfish (Procambarus clarkii)
In this study, integrated analyses of antioxidant enzyme activity, histopathological damage, 16S rRNA gene sequencing, and liquid chromatography-mass spectrometry (LC-MS) were performed to investigate the physiology, histopathology, microbiota, and metabolite changes in crayfish intestines exposed to LpH treatment. The results showed that LpH stress induced obvious changes in superoxide dismutase and catalase activities and histopathological alterations in crayfish intestines. Furthermore, 16S rRNA gene sequencing analysis revealed that exposure to LpH caused significant alterations in the diversity and composition of the ...
Source: Aquatic Toxicology - March 19, 2024 Category: Toxicology Authors: Zhanqi Wang Jiapeng Li Pengfei Zhao Zaihang Yu Lianlian Yang Xueyan Ding He Lv ShaoKui Yi Qiang Sheng Liqin Zhang Fan Zhou Hua Wang Source Type: research
From antioxidant defense to genotoxicity: Deciphering the tissue-specific impact of AgNPs on marine clam Ruditapes philippinarum
This study explores the impact of AgNPs (50 μg/L) on the marine clam Ruditapes philippinarum, with a particular focus on its gills and digestive glands. We adopted an integrated approach that combined in vivo exposure, biochemical assays, and transcriptomic analysis to evaluate the toxicity of AgNPs. The results revealed substantial accumulation of AgNPs in the gills and digestive glands of R. philippinarum, resulting in oxidative stress and DNA damage, with the gills showing more severe oxidative damage. Transcriptomic analysis further highlights an adaptive up-regulation of peroxisome-related genes in the gills respondi...
Source: Aquatic Toxicology - March 19, 2024 Category: Toxicology Authors: Yang-Yang Xing Xin-Ming Pu Jin-Fen Pan Jia-Yin Xu Chen Liu De-Chi Lu Source Type: research
Integrated microbiome and metabolome analyses reveal the effects of low pH on intestinal health and homeostasis of crayfish (Procambarus clarkii)
In this study, integrated analyses of antioxidant enzyme activity, histopathological damage, 16S rRNA gene sequencing, and liquid chromatography-mass spectrometry (LC-MS) were performed to investigate the physiology, histopathology, microbiota, and metabolite changes in crayfish intestines exposed to LpH treatment. The results showed that LpH stress induced obvious changes in superoxide dismutase and catalase activities and histopathological alterations in crayfish intestines. Furthermore, 16S rRNA gene sequencing analysis revealed that exposure to LpH caused significant alterations in the diversity and composition of the ...
Source: Aquatic Toxicology - March 19, 2024 Category: Toxicology Authors: Zhanqi Wang Jiapeng Li Pengfei Zhao Zaihang Yu Lianlian Yang Xueyan Ding He Lv ShaoKui Yi Qiang Sheng Liqin Zhang Fan Zhou Hua Wang Source Type: research
From antioxidant defense to genotoxicity: Deciphering the tissue-specific impact of AgNPs on marine clam Ruditapes philippinarum
This study explores the impact of AgNPs (50 μg/L) on the marine clam Ruditapes philippinarum, with a particular focus on its gills and digestive glands. We adopted an integrated approach that combined in vivo exposure, biochemical assays, and transcriptomic analysis to evaluate the toxicity of AgNPs. The results revealed substantial accumulation of AgNPs in the gills and digestive glands of R. philippinarum, resulting in oxidative stress and DNA damage, with the gills showing more severe oxidative damage. Transcriptomic analysis further highlights an adaptive up-regulation of peroxisome-related genes in the gills respondi...
Source: Aquatic Toxicology - March 19, 2024 Category: Toxicology Authors: Yang-Yang Xing Xin-Ming Pu Jin-Fen Pan Jia-Yin Xu Chen Liu De-Chi Lu Source Type: research
Role of benzophenone-3 additive in the effect of polyethylene microplastics on Daphnia magna population dynamics
This study investigated the effect of polyethylene MP fragments (33.90 ± 17.44 μm) and benzophenone-3 (BP-3), which is a widely used plastic additive (2.91 ± 0.02% w/w), on D. magna population dynamics in a 34-day microcosm experiment. In the growth phase, neither MP nor MP/BP-3 fragments changed the population size of D. magna compared with the control. However, MP/BP-3 fragments significantly reduced (p < 0.05) the population biomass compared to that of the control, whereas MP fragments did not induce a significant reduction. The MP/BP-3 group had a significantly higher (p < 0.05) neonate proportion than that in...
Source: Aquatic Toxicology - March 17, 2024 Category: Toxicology Authors: Changhae Kim Gabriela Kal číková Jinho Jung Source Type: research
Role of benzophenone-3 additive in the effect of polyethylene microplastics on Daphnia magna population dynamics
This study investigated the effect of polyethylene MP fragments (33.90 ± 17.44 μm) and benzophenone-3 (BP-3), which is a widely used plastic additive (2.91 ± 0.02% w/w), on D. magna population dynamics in a 34-day microcosm experiment. In the growth phase, neither MP nor MP/BP-3 fragments changed the population size of D. magna compared with the control. However, MP/BP-3 fragments significantly reduced (p < 0.05) the population biomass compared to that of the control, whereas MP fragments did not induce a significant reduction. The MP/BP-3 group had a significantly higher (p < 0.05) neonate proportion than that in...
Source: Aquatic Toxicology - March 17, 2024 Category: Toxicology Authors: Changhae Kim Gabriela Kal číková Jinho Jung Source Type: research
Role of benzophenone-3 additive in the effect of polyethylene microplastics on Daphnia magna population dynamics
This study investigated the effect of polyethylene MP fragments (33.90 ± 17.44 μm) and benzophenone-3 (BP-3), which is a widely used plastic additive (2.91 ± 0.02% w/w), on D. magna population dynamics in a 34-day microcosm experiment. In the growth phase, neither MP nor MP/BP-3 fragments changed the population size of D. magna compared with the control. However, MP/BP-3 fragments significantly reduced (p < 0.05) the population biomass compared to that of the control, whereas MP fragments did not induce a significant reduction. The MP/BP-3 group had a significantly higher (p < 0.05) neonate proportion than that in...
Source: Aquatic Toxicology - March 17, 2024 Category: Toxicology Authors: Changhae Kim Gabriela Kal číková Jinho Jung Source Type: research
Toxicological Research on Nano and Microplastics in Environmental Pollution: Current Advances and Future Directions
In conclusion, plastic pollution is a pressing issue that governments should tackle by ensuring proper implementation of rules and regulations at national and provincial levels to reduce its health risks.PMID:38492287 | DOI:10.1016/j.aquatox.2024.106894 (Source: Aquatic Toxicology)
Source: Aquatic Toxicology - March 16, 2024 Category: Toxicology Authors: Saurabh Shukla Yang Pei Wei-Guo Li De-Sheng Pei Source Type: research
Reproductive endocrine disruption effect and mechanism in male zebrafish after life cycle exposure to environmental relevant triclosan
This study sheds light on the reproductive endocrine-disrupting mechanisms of life cycle exposure to TCS.PMID:38492288 | DOI:10.1016/j.aquatox.2024.106899 (Source: Aquatic Toxicology)
Source: Aquatic Toxicology - March 16, 2024 Category: Toxicology Authors: Fan Wang Source Type: research
The acute neurotoxicity of inorganic mercury in Mactra chinensis philippi
Aquat Toxicol. 2024 Mar 12;270:106896. doi: 10.1016/j.aquatox.2024.106896. Online ahead of print.ABSTRACTInorganic mercury (IHg) is hazardous to marine organisms especially resulting in neurotoxicity, bivalves are sensitive to pollutants as "ocean sentinel", but data on the neurotoxicity of IHg in bivalves are sparse. So we chosed M. chinensis philippi with typical neural structures in bivalves to investigate the neurotoxicity of IHg, which could be helpful to understand the specificity of neural regulation and the response characteristics of bivalves. After acute exposed to IHg (HgCl2) for 24 h, the metabolites of ganglio...
Source: Aquatic Toxicology - March 15, 2024 Category: Toxicology Authors: Bangguo Ma Xiaoli Zhao Xiaoning Zhang Bowen Yang Zimin Cai Zihan Xing Mingzhe Xu Liuya Mi Jianning Zhang Lei Wang Yancui Zhao Xiaoli Liu Source Type: research
