Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency
Annu Rev Pathol. 2023 Oct 23. doi: 10.1146/annurev-pathmechdis-051222-121126. Online ahead of print.ABSTRACTThe enzyme ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) codes for a type 2 transmembrane glycoprotein that hydrolyzes extracellular ATP to generate pyrophosphate (PPi) and adenosine monophosphate, thereby contributing to downstream purinergic signaling pathways. The clinical phenotypes induced by ENPP1 deficiency are seemingly contradictory and include early-onset osteoporosis in middle-aged adults and life-threatening vascular calcifications in the large arteries of infants with generalized arterial ca...
Source: Annual Review of Pathology - October 23, 2023 Category: Pathology Authors: Carlos R Ferreira Thomas O Carpenter Demetrios T Braddock Source Type: research
Toward Explainable Artificial Intelligence for Precision Pathology
Annu Rev Pathol. 2023 Oct 23. doi: 10.1146/annurev-pathmechdis-051222-113147. Online ahead of print.ABSTRACTThe rapid development of precision medicine in recent years has started to challenge diagnostic pathology with respect to its ability to analyze histological images and increasingly large molecular profiling data in a quantitative, integrative, and standardized way. Artificial intelligence (AI) and, more precisely, deep learning technologies have recently demonstrated the potential to facilitate complex data analysis tasks, including clinical, histological, and molecular data for disease classification; tissue biomar...
Source: Annual Review of Pathology - October 23, 2023 Category: Pathology Authors: Frederick Klauschen Jonas Dippel Philipp Keyl Philipp Jurmeister Michael Bockmayr Andreas Mock Oliver Buchstab Maximilian Alber Lukas Ruff Gr égoire Montavon Klaus-Robert M üller Source Type: research
ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency
Annu Rev Pathol. 2023 Oct 23. doi: 10.1146/annurev-pathmechdis-051222-121126. Online ahead of print.ABSTRACTThe enzyme ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) codes for a type 2 transmembrane glycoprotein that hydrolyzes extracellular ATP to generate pyrophosphate (PPi) and adenosine monophosphate, thereby contributing to downstream purinergic signaling pathways. The clinical phenotypes induced by ENPP1 deficiency are seemingly contradictory and include early-onset osteoporosis in middle-aged adults and life-threatening vascular calcifications in the large arteries of infants with generalized arterial ca...
Source: Annual Review of Pathology - October 23, 2023 Category: Pathology Authors: Carlos R Ferreira Thomas O Carpenter Demetrios T Braddock Source Type: research
Toward Explainable Artificial Intelligence for Precision Pathology
Annu Rev Pathol. 2023 Oct 23. doi: 10.1146/annurev-pathmechdis-051222-113147. Online ahead of print.ABSTRACTThe rapid development of precision medicine in recent years has started to challenge diagnostic pathology with respect to its ability to analyze histological images and increasingly large molecular profiling data in a quantitative, integrative, and standardized way. Artificial intelligence (AI) and, more precisely, deep learning technologies have recently demonstrated the potential to facilitate complex data analysis tasks, including clinical, histological, and molecular data for disease classification; tissue biomar...
Source: Annual Review of Pathology - October 23, 2023 Category: Pathology Authors: Frederick Klauschen Jonas Dippel Philipp Keyl Philipp Jurmeister Michael Bockmayr Andreas Mock Oliver Buchstab Maximilian Alber Lukas Ruff Gr égoire Montavon Klaus-Robert M üller Source Type: research
ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency
Annu Rev Pathol. 2023 Oct 23. doi: 10.1146/annurev-pathmechdis-051222-121126. Online ahead of print.ABSTRACTThe enzyme ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) codes for a type 2 transmembrane glycoprotein that hydrolyzes extracellular ATP to generate pyrophosphate (PPi) and adenosine monophosphate, thereby contributing to downstream purinergic signaling pathways. The clinical phenotypes induced by ENPP1 deficiency are seemingly contradictory and include early-onset osteoporosis in middle-aged adults and life-threatening vascular calcifications in the large arteries of infants with generalized arterial ca...
Source: Annual Review of Pathology - October 23, 2023 Category: Pathology Authors: Carlos R Ferreira Thomas O Carpenter Demetrios T Braddock Source Type: research
