Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2024 Jan 24;19:571-598. doi: 10.1146/annurev-pathmechdis-051222-013421. Epub 2023 Oct 31.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
