Chance and Opportunity: A Personal Story
This article summarizes my personal life story, from early education in India to research, teaching, and other activities in Boston and San Francisco. I have tried to illustrate how unplanned events shape one's path, and why the willingness to go with the flow is among one's most valuable attributes.PMID:38265881 | DOI:10.1146/annurev-pathmechdis-052323-040230 (Source: Annual Review of Pathology)
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Abul K Abbas Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Neutrophils in Physiology and Pathology
Annu Rev Pathol. 2024 Jan 24;19:227-259. doi: 10.1146/annurev-pathmechdis-051222-015009.ABSTRACTInfections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we rev...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Alejandra Aroca-Crevill én Tommaso Vicanolo Samuel Ovadia Andr és Hidalgo Source Type: research
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury
Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016.ABSTRACTAcetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling events starting with drug metabolism and the central role of mitochondrial dysfunction involving oxidant stress and peroxynitrite. Mitochondria-derived endonucleases trigger nuclear DNA fragmentation, the point of no return for cell death. In addition, adaptive mechanisms that limi...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Hartmut Jaeschke Anup Ramachandran Source Type: research
Chance and Opportunity: A Personal Story
This article summarizes my personal life story, from early education in India to research, teaching, and other activities in Boston and San Francisco. I have tried to illustrate how unplanned events shape one's path, and why the willingness to go with the flow is among one's most valuable attributes.PMID:38265881 | DOI:10.1146/annurev-pathmechdis-052323-040230 (Source: Annual Review of Pathology)
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Abul K Abbas Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Neutrophils in Physiology and Pathology
Annu Rev Pathol. 2024 Jan 24;19:227-259. doi: 10.1146/annurev-pathmechdis-051222-015009.ABSTRACTInfections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we rev...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Alejandra Aroca-Crevill én Tommaso Vicanolo Samuel Ovadia Andr és Hidalgo Source Type: research
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury
Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016.ABSTRACTAcetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling events starting with drug metabolism and the central role of mitochondrial dysfunction involving oxidant stress and peroxynitrite. Mitochondria-derived endonucleases trigger nuclear DNA fragmentation, the point of no return for cell death. In addition, adaptive mechanisms that limi...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Hartmut Jaeschke Anup Ramachandran Source Type: research
Chance and Opportunity: A Personal Story
This article summarizes my personal life story, from early education in India to research, teaching, and other activities in Boston and San Francisco. I have tried to illustrate how unplanned events shape one's path, and why the willingness to go with the flow is among one's most valuable attributes.PMID:38265881 | DOI:10.1146/annurev-pathmechdis-052323-040230 (Source: Annual Review of Pathology)
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Abul K Abbas Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Neutrophils in Physiology and Pathology
Annu Rev Pathol. 2024 Jan 24;19:227-259. doi: 10.1146/annurev-pathmechdis-051222-015009.ABSTRACTInfections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we rev...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Alejandra Aroca-Crevill én Tommaso Vicanolo Samuel Ovadia Andr és Hidalgo Source Type: research
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury
Annu Rev Pathol. 2024 Jan 24;19:453-478. doi: 10.1146/annurev-pathmechdis-051122-094016.ABSTRACTAcetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug. This review covers intracellular signaling events starting with drug metabolism and the central role of mitochondrial dysfunction involving oxidant stress and peroxynitrite. Mitochondria-derived endonucleases trigger nuclear DNA fragmentation, the point of no return for cell death. In addition, adaptive mechanisms that limi...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Hartmut Jaeschke Anup Ramachandran Source Type: research
Chance and Opportunity: A Personal Story
This article summarizes my personal life story, from early education in India to research, teaching, and other activities in Boston and San Francisco. I have tried to illustrate how unplanned events shape one's path, and why the willingness to go with the flow is among one's most valuable attributes.PMID:38265881 | DOI:10.1146/annurev-pathmechdis-052323-040230 (Source: Annual Review of Pathology)
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Abul K Abbas Source Type: research
Pediatric Cholestatic Diseases: Common and Unique Pathogenic Mechanisms
Annu Rev Pathol. 2024 Jan 24;19:319-344. doi: 10.1146/annurev-pathmechdis-031521-025623.ABSTRACTCholestasis is the predominate feature of many pediatric hepatobiliary diseases. The physiologic flow of bile requires multiple complex processes working in concert. Bile acid (BA) synthesis and excretion, the formation and flow of bile, and the enterohepatic reuptake of BAs all function to maintain the circulation of BAs, a key molecule in lipid digestion, metabolic and cellular signaling, and, as discussed in the review, a crucial mediator in the pathogenesis of cholestasis. Disruption of one or several of these steps can resu...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Harry Sutton Saul J Karpen Binita M Kamath Source Type: research
Neutrophils in Physiology and Pathology
Annu Rev Pathol. 2024 Jan 24;19:227-259. doi: 10.1146/annurev-pathmechdis-051222-015009.ABSTRACTInfections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we rev...
Source: Annual Review of Pathology - January 24, 2024 Category: Pathology Authors: Alejandra Aroca-Crevill én Tommaso Vicanolo Samuel Ovadia Andr és Hidalgo Source Type: research
