Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
Haploinsufficient Transcription Factors in Myeloid Neoplasms
Annu Rev Pathol. 2023 Oct 31. doi: 10.1146/annurev-pathmechdis-051222-013421. Online ahead of print.ABSTRACTMany transcription factors (TFs) function as tumor suppressor genes with heterozygous phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia. This is no less true in myeloid cells, which are normally regulated by a delicately balanced and interconnected transcriptional network. Detailed understanding of TF dose in this circuitry sheds light on the leukemic transcriptome. In this review, we discuss the emerging features of haploinsufficient transcription factors (HITFs). We posit that: ...
Source: Annual Review of Pathology - October 31, 2023 Category: Pathology Authors: Tanner C Martinez Megan E McNerney Source Type: research
