A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
Lipid Quality Control and Ferroptosis: From Concept to Mechanism
Annu Rev Biochem. 2023 Nov 14. doi: 10.1146/annurev-biochem-052521-033527. Online ahead of print.ABSTRACTCellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells r...
Source: Annual Review of Biochemistry - November 14, 2023 Category: Biochemistry Authors: Zhipeng Li Mike Lange Scott J Dixon James A Olzmann Source Type: research
The acyl carrier proteins of lipid synthesis are busy having other affairs
Biochem J. 2023 Jun 28;480(12):855-873. doi: 10.1042/BCJ20230161.ABSTRACTThis is a review of the acyl carrier proteins (ACPs) of type II fatty acid synthesis in bacteria and mitochondria, their structures and protein interactions. Type II fatty acid synthesis in bacteria (Prog. Lipid Res. (2013) 52, 249-276; Biochim. Biophys. Acta (1996) 1302, 1-16; Annu. Rev. Biochem. (2005) 74, 791-831) and in the mitochondria of yeast and mammals (Biochim. Biophys. Acta Mol. Cell. Res. (2019) 1866, 118540; MedChemComm (2019) 10, 209-220; Elife (2016) 5, e17828; Mol. Cell (2018) 71, 567-580.e4) will be discussed only tangentially in this...
Source: Annual Review of Biochemistry - June 22, 2023 Category: Biochemistry Authors: John E Cronan Source Type: research
