FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network
Annu Rev Plant Biol. 2024 Feb 29. doi: 10.1146/annurev-arplant-102820-103424. Online ahead of print.ABSTRACTInitially identified as a key regulator of female fertility in Arabidopsis, the FERONIA (FER) receptor kinase is now recognized as crucial for almost all aspects of plant growth and survival. FER partners with a glycosylphosphatidylinositol-anchored protein of the LLG family to act as coreceptors on the cell surface. The FER-LLG coreceptor interacts with different RAPID ALKALINIZATION FACTOR (RALF) peptide ligands to function in various growth and developmental processes and to respond to challenges from the environm...
Source: Annual Review of Biochemistry - February 29, 2024 Category: Biochemistry Authors: Alice Y Cheung Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
