Looping the Genome with SMC Complexes
We describe the mechanistic biophysical aspects of loop extrusion that govern genome organization and its consequences. Expected final online publication date for the Annual Review of Biochemistry, Volume 92 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37137166 | DOI:10.1146/annurev-biochem-032620-110506 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - May 3, 2023 Category: Biochemistry Authors: Eugene Kim Roman Barth Cees Dekker Source Type: research
Looping the Genome with SMC Complexes
We describe the mechanistic biophysical aspects of loop extrusion that govern genome organization and its consequences. Expected final online publication date for the Annual Review of Biochemistry, Volume 92 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37137166 | DOI:10.1146/annurev-biochem-032620-110506 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - May 3, 2023 Category: Biochemistry Authors: Eugene Kim Roman Barth Cees Dekker Source Type: research
Looping the Genome with SMC Complexes
We describe the mechanistic biophysical aspects of loop extrusion that govern genome organization and its consequences. Expected final online publication date for the Annual Review of Biochemistry, Volume 92 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37137166 | DOI:10.1146/annurev-biochem-032620-110506 (Source: Annual Review of Biochemistry)
Source: Annual Review of Biochemistry - May 3, 2023 Category: Biochemistry Authors: Eugene Kim Roman Barth Cees Dekker Source Type: research
Rubisco Function, Evolution, and Engineering
Annu Rev Biochem. 2023 Apr 26. doi: 10.1146/annurev-biochem-040320-101244. Online ahead of print.ABSTRACTCarbon fixation is the process by which CO2 is converted from a gas into biomass. The Calvin-Benson-Bassham cycle (CBB) is the dominant carbon-consuming pathway on Earth, driving >99.5% of the ∼120 billion tons of carbon that are converted to sugar by plants, algae, and cyanobacteria. The carboxylase enzyme in the CBB, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco), fixes one CO2 molecule per turn of the cycle into bioavailable sugars. Despite being critical to the assimilation of carbon, rubisco's kinet...
Source: Annual Review of Biochemistry - May 1, 2023 Category: Biochemistry Authors: Noam Prywes Naiya R Phillips Owen T Tuck Luis E Valentin-Alvarado David F Savage Source Type: research
Rubisco Function, Evolution, and Engineering
Annu Rev Biochem. 2023 Apr 26. doi: 10.1146/annurev-biochem-040320-101244. Online ahead of print.ABSTRACTCarbon fixation is the process by which CO2 is converted from a gas into biomass. The Calvin-Benson-Bassham cycle (CBB) is the dominant carbon-consuming pathway on Earth, driving >99.5% of the ∼120 billion tons of carbon that are converted to sugar by plants, algae, and cyanobacteria. The carboxylase enzyme in the CBB, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco), fixes one CO2 molecule per turn of the cycle into bioavailable sugars. Despite being critical to the assimilation of carbon, rubisco's kinet...
Source: Annual Review of Biochemistry - May 1, 2023 Category: Biochemistry Authors: Noam Prywes Naiya R Phillips Owen T Tuck Luis E Valentin-Alvarado David F Savage Source Type: research
Thiolase: A Versatile Biocatalyst Employing CoA-Thioester Chemistry for Making and Breaking C-C Bonds
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-033746. Online ahead of print.ABSTRACTThiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thiolases have two reactive cysteines: (a) a nucleophilic cysteine, which forms a covalent intermediate, and (b) an acid/base cysteine. The best characterized thiolase is the Zoogloea ramigera thiolase, which is a bacterial biosynthetic thiolase belonging to the CT-thiolase sub...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Rajesh K Harijan Subhadra Dalwani Tiila-Riikka Kiema Rajaram Venkatesan Rik K Wierenga Source Type: research
The Proteins of mRNA Modification: Writers, Readers, and Erasers
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-035330. Online ahead of print.ABSTRACTOver the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N 6-methyladenosine (m6A). We first...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Mathieu N Flamand Matthew Tegowski Kate D Meyer Source Type: research
Thiolase: A Versatile Biocatalyst Employing CoA-Thioester Chemistry for Making and Breaking C-C Bonds
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-033746. Online ahead of print.ABSTRACTThiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thiolases have two reactive cysteines: (a) a nucleophilic cysteine, which forms a covalent intermediate, and (b) an acid/base cysteine. The best characterized thiolase is the Zoogloea ramigera thiolase, which is a bacterial biosynthetic thiolase belonging to the CT-thiolase sub...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Rajesh K Harijan Subhadra Dalwani Tiila-Riikka Kiema Rajaram Venkatesan Rik K Wierenga Source Type: research
The Proteins of mRNA Modification: Writers, Readers, and Erasers
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-035330. Online ahead of print.ABSTRACTOver the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N 6-methyladenosine (m6A). We first...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Mathieu N Flamand Matthew Tegowski Kate D Meyer Source Type: research
Thiolase: A Versatile Biocatalyst Employing CoA-Thioester Chemistry for Making and Breaking C-C Bonds
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-033746. Online ahead of print.ABSTRACTThiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thiolases have two reactive cysteines: (a) a nucleophilic cysteine, which forms a covalent intermediate, and (b) an acid/base cysteine. The best characterized thiolase is the Zoogloea ramigera thiolase, which is a bacterial biosynthetic thiolase belonging to the CT-thiolase sub...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Rajesh K Harijan Subhadra Dalwani Tiila-Riikka Kiema Rajaram Venkatesan Rik K Wierenga Source Type: research
The Proteins of mRNA Modification: Writers, Readers, and Erasers
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-035330. Online ahead of print.ABSTRACTOver the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N 6-methyladenosine (m6A). We first...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Mathieu N Flamand Matthew Tegowski Kate D Meyer Source Type: research
Thiolase: A Versatile Biocatalyst Employing CoA-Thioester Chemistry for Making and Breaking C-C Bonds
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-033746. Online ahead of print.ABSTRACTThiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thiolases have two reactive cysteines: (a) a nucleophilic cysteine, which forms a covalent intermediate, and (b) an acid/base cysteine. The best characterized thiolase is the Zoogloea ramigera thiolase, which is a bacterial biosynthetic thiolase belonging to the CT-thiolase sub...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Rajesh K Harijan Subhadra Dalwani Tiila-Riikka Kiema Rajaram Venkatesan Rik K Wierenga Source Type: research
The Proteins of mRNA Modification: Writers, Readers, and Erasers
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-035330. Online ahead of print.ABSTRACTOver the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N 6-methyladenosine (m6A). We first...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Mathieu N Flamand Matthew Tegowski Kate D Meyer Source Type: research
Thiolase: A Versatile Biocatalyst Employing CoA-Thioester Chemistry for Making and Breaking C-C Bonds
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-033746. Online ahead of print.ABSTRACTThiolases are CoA-dependent enzymes that catalyze the thiolytic cleavage of 3-ketoacyl-CoA, as well as its reverse reaction, which is the thioester-dependent Claisen condensation reaction. Thiolases are dimers or tetramers (dimers of dimers). All thiolases have two reactive cysteines: (a) a nucleophilic cysteine, which forms a covalent intermediate, and (b) an acid/base cysteine. The best characterized thiolase is the Zoogloea ramigera thiolase, which is a bacterial biosynthetic thiolase belonging to the CT-thiolase sub...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Rajesh K Harijan Subhadra Dalwani Tiila-Riikka Kiema Rajaram Venkatesan Rik K Wierenga Source Type: research
The Proteins of mRNA Modification: Writers, Readers, and Erasers
Annu Rev Biochem. 2023 Apr 17. doi: 10.1146/annurev-biochem-052521-035330. Online ahead of print.ABSTRACTOver the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification, N 6-methyladenosine (m6A). We first...
Source: Annual Review of Biochemistry - April 17, 2023 Category: Biochemistry Authors: Mathieu N Flamand Matthew Tegowski Kate D Meyer Source Type: research
