The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Annu Rev Biochem. 2024 Feb 12. doi: 10.1146/annurev-biochem-030122-033116. Online ahead of print.ABSTRACTThe nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flex...
Source: Annual Review of Biochemistry - February 12, 2024 Category: Biochemistry Authors: Marco Cecchini Pierre-Jean Corringer Jean-Pierre Changeux Source Type: research
Signaling from RAS to RAF: The Molecules and Their Mechanisms
Annu Rev Biochem. 2024 Feb 5. doi: 10.1146/annurev-biochem-052521-040754. Online ahead of print.ABSTRACTRAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the signaling cascade that controls cellular proliferation, differentiation, and survival in response to engagement of growth factor receptors on the cell surface. Over the past few years, structural and biochemical studies have provided new understanding of RAF autoregulation, RAF activation by RAS and the SHOC2 phosphatase complex, and RAF engagement with HSP90-CDC37 chaperone complexes. These studies have important implications for pharmacolo...
Source: Annual Review of Biochemistry - February 5, 2024 Category: Biochemistry Authors: Hyesung Jeon Emre Tkacik Michael J Eck Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
A Life of Translocations
Annu Rev Biochem. 2023 Nov 29. doi: 10.1146/annurev-biochem-030122-040444. Online ahead of print.ABSTRACTWriting a career retrospective for this prestigious series is a huge challenge. Is my story really of that much interest? One thing that is different about my life in science is the heavy influence of the turmoil of the past century. Born in the US, raised in East Germany, and returning to the US relatively late in life, I experienced research under both suboptimal and privileged conditions. My scientific story, like the political winds that blew me from one continent to the next, involved shifts into different fields. ...
Source: Annual Review of Biochemistry - November 29, 2023 Category: Biochemistry Authors: Tom A Rapoport Source Type: research
