Internal Carotid Artery Blood Flow Response to Anesthesia, Pneumoperitoneum, and Head-up Tilt during Laparoscopic Cholecystectomy
Editor ’s PerspectiveWhat We Already Know about This TopicCardiac output is an independent regulator of cerebral blood flow in healthy awake humansThe relationship between cardiac output and cerebral blood flow in anesthetized patients undergoing laparoscopy has not been previously characterizedWhat This Article Tells Us That Is NewAt steady-state depth of anesthesia, in patients undergoing laparoscopic cholecystectomy, creation of pneumoperitoneum decreased cardiac output and internal carotid artery blood flow while mean arterial pressure and end-tidal carbon dioxide levels remained unchangedBackground Little is kno...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Pectoralis-II Myofascial Block and Analgesia in Breast Cancer Surgery A Systematic Review and Meta-analysis
Editor ’s PerspectiveWhat We Already Know about This TopicPectoralis-II block is a potential alternative to paravertebral blocks to provide regional analgesia for breast cancer surgeryWhat This Article Tells Us That Is NewThis meta-analysis includes 14 randomized trials comparing pectoralis-II block with paravertebral blocks and found that there were no differences in pain scores or opioid consumption between the two groups in patients having surgery for breast cancerPectoralis-II blocks were noninferior to paravertebral blocks in reducing pain intensity and morphine consumption for the first 24 h after surgery and b...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Oxidants Regulated Diaphragm Proteolysis during Mechanical Ventilation in Rats
Conclusions Prolonged controlled mechanical ventilation activates the proteasome and autophagy pathways in the diaphragm through oxidative stress. Pathway activation is accomplished, in part, through inhibition of microRNAs that negatively regulate autophagy-related genes. (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Trends in Direct Hospital Payments to Anesthesia Groups A Retrospective Cohort Study of Nonacademic Hospitals in California
Conclusions Direct payments from hospitals are becoming a larger financial consideration for anesthesia groups in California serving nonacademic hospitals, and are larger for groups working at hospitals serving publicly insured patients. (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Superior Trunk Block A Phrenic-sparing Alternative to the Interscalene Block: A Randomized Controlled Trial
Editor ’s PerspectiveWhat We Already Know about This TopicInterscalene nerve block is commonly used for shoulder surgery for anesthesia and postoperative analgesiaUnfortunately, interscalene blocks commonly result in hemidiaphragmatic paralysisWhat This Article Tells Us That Is NewWhen interscalene block was compared with superior trunk block, less frequent hemidiaphragmatic paralysis was seen in the superior trunk block groupSuperior trunk block was noninferior to interscalene block in terms of worst pain scores in the recovery room, and superior trunk block patients were more satisfiedBackground Interscalene nerve ...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Cognitive Effects of Perioperative Pregabalin: Comment
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Cognitive Effects of Perioperative Pregabalin: Reply
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Resident Mental Health Time for Action
“Social media may be contributing to…elevated rates of [anesthesiology resident] distress.” (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living
Conclusions Postoperative delirium was associated with long-term detrimental outcomes, including greater decline in activities of daily living and a higher rate of postoperative mortality. (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Driving Pressure Is Associated with Outcome during Assisted Ventilation in Acute Respiratory Distress Syndrome
This study shows that in the majority of adult patients with acute respiratory distress syndrome, both driving pressure and respiratory system compliance can be reliably measured during pressure support (assisted) ventilation.Higher driving pressure measured during pressure support (assisted) ventilation significantly associates with increased intensive care unit mortality, whereas peak inspiratory pressure does not.Lower respiratory system compliance also significantly associates with increased intensive care unit mortality.Background Driving pressure, the difference between plateau pressure and positive end-expiratory pr...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Down Under the Deep
I drew in a deep breath (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Crystalloid/Colloid Renal and Disability Outcomes: Comment
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Crystalloid/Colloid Renal and Disability Outcomes: Reply
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice
Conclusions From these data we conclude that the loperamide –oxymorphindole combination synergistically reverses complete Freund’s adjuvant–induced inflammatory hyperalgesia. The authors also conclude that this interaction is mediated by opioid receptors located in the peripheral nervous system. (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster
Editor ’s PerspectiveWhat We Already Know about This TopicSyntaxin1A is a presynaptic molecule that plays a key role in vesicular neurotransmitter releaseMutations of syntaxin1A result in resistance to both volatile and intravenous anestheticsTruncated syntaxin1A isoforms confer drug resistance in cell culture and nematode models of anesthesiaWhat This Article Tells Us That Is NewResistance to isoflurane anesthesia can be produced by transiently expressing truncated syntaxin1A proteins in adult Drosophila fliesElectrophysiologic and behavioral studies in Drosophila show that mutations in syntaxin1A facilitate recover...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Anesthesiology
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

This Month in Anesthesiology
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Science, Medicine, and the Anesthesiologist
Key Papers from the Most Recent Literature Relevant to Anesthesiologists (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Full Strength, but Impaired Response: Neuromuscular Blockade and the Carotid Body
Complex Information for Anesthesiologists Presented Quickly and Clearly (Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Instructions for Obtaining A nesthesiology Continuing Medical Education (CME) Credit
(Source: Anesthesiology)
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Anesthetic Inductions from Hexobarbital to Pentothal: Counting Down from 6 to 5?
The search for ultra-short-acting intravenous induction agents focused initially on hexobarbital. That methylated oxybarbiturate was discovered in 1932 by German researchers H. Weese and W. Scharpf. Marketed by the Bayer Company in Europe as Evipan, hexobarbital was distributed by New York ’s Winthrop Chemical Company as “Evipal Soluble” (above). Hexobarbital has a six-carbon side-ring of cyclohexene. Contrast that with the thiobarbiturate that supplanted hexobarbital: sodium thiopental (branded Pentothal by Abbott Laboratories, USA), which has a five-carbon side chain of pentane. (Copyright © the Am...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Dr. Frank A. Shattuck ’s Unfolding “Specialty, the Administration of Nitrous Oxide Gas”
According to New York City directories, Dr. Frank Alton Shattuck ran his dental office at 297 West Twelfth Street from roughly 1883 through 1887. So, this four-page advertising folder (lower right) was apparently printed sometime in the mid-1880s. Trained under a dental preceptor, Dr. Shattuck advertised his practice as embracing “all branches of the profession.” On the inside of this elegant folder from the Wood Library-Museum’s Ben Z. Swanson Collection, Dr. Shattuck trumpets that his practice includes “as a specialty, the administration of Nitrous Oxide Gas” (upper left). (Copyright © ...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Antipodal Views on Branding Amylocaine as Stovaine: Modesty or Political Correctness?
After surgeons revealed in 1904 that researcher Ernest A. Fourneau (1872 to 1949) had synthesized an alternative local anesthetic to cocaine, his Parisian firm, Poulenc Fr ères, branded his amylocaine as “Stovaine” for their English-speaking consumers. Over the years, that branding has been viewed quite differently by anesthesia museum curators in the southern and northern hemispheres. In Australia, “Stovaine” was characterized by Drs. C. M. Ball and R. N. We sthorpe as “modestly named with an anglicized version of his own name (Fourneau meaning furnace or stove).” However, in the...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

The Appearance and Disappearance of Dr. Edwin J. Thompson, Lynn ’s Celebrated Administrator of Nitrous Oxide
In 1879, I. A. Collins glued a copy of his cabinet photograph (upper) of a dental office in Lynn, Massachusetts, to an advertising card for dentist Edwin J. Thompson (ca. 1842 to 1912). Above the firm of Alfred Cross& Co., Clothiers, the dentist placed signage in the second-floor bay windows reading, “Teeth Extracted with Nitrous Oxide Gas” (lower left) by “Dr. Thompson Dentist” (lower middle). Through the open flanking window (lower right), photographer Collins may have captured the fleeting appearances of Dr. Thompson himself and an assistant gazing through the glazing. In 1912, the citizens o...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Turning Trash Cans into Iron Lungs: Dr. Robert M. Coffey, the “Genius of Juneau”
Portland surgical pioneer Robert Calvin Coffey named his youngest son Robert Mayo Coffey (1906 to 1972,right). The latter earned his M.D. at the University of Michigan and returned with his wife to his native Oregon. By 1937 the couple and their two young daughters were living in Juneau, Alaska. When neighboring children were quarantined with infantile paralysis, the resourceful Dr. Coffey began converting trash cans into iron lungs (left), just in case any children developed breathing difficulties. Electrical valves on Coffey ’s “pressure and reserve tanks” alternated positive and negative pressures for ...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Practical Operating Theater Management: Measuring and Improving Performance and Patient Experience
Because most anesthesiologists work in the operating room setting, anesthesiologists are involved with the management of the operating room suite (or “theater”). Even if they are not responsible for the management, anesthesiologists still want to understand the decision-making process and metrics that affect their daily schedule and duties. In the United States, anesthesiologists can attend in-person conferences and seminars on leadership, pr actice management, and operating room management offered by national associations, online webinars and resources, and textbooks. Although these offerings will give anesthe...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Adjunctive Corticosteroid Treatment in Septic Shock
Interest in the role of the adrenal cortex in the recovery from an infection dates back nearly 100 yr. More than six decades of research on the role of corticosteroid supplementation as an adjunctive treatment for sepsis and septic shock failed to reveal conclusive results. Recently two large-scale randomized controlled trials have added substantial new data to inform opinion regarding the role of corticosteroids in the treatment of septic shock.1,2 In this article, we review the background, the current state of the evidence, and ongoing areas of uncertainty in this field and provide suggestions for clinical practice. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Failure to Rescue as a Surgical Quality Indicator Current Concepts and Future Directions for Improving Surgical Outcomes
Over the past decade, failure to rescue —defined as the death of a patient after one or more potentially treatable complications—has received increased attention as a surgical quality indicator. Failure to rescue is an appealing quality target because it implicitly accounts for the fact that postoperative complications may not always be preventable and is based on the premise that prompt recognition and treatment of complications is a critical, actionable point during a patient’s postoperative course. Although numerous patient and macrosystem factors have been associated with failure to rescue, there is a...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Propofol Sedation Alters Perceptual and Cognitive Functions in Healthy Volunteers as Revealed by Functional Magnetic Resonance Imaging
Editor ’s PerspectiveWhat We Already Know about This TopicLoss of consciousness during anesthesia is associated with a loss of anterior –posterior connectivityHowever, during anesthesia local sensory cortex function may be preservedWhat This Article Tells Us That Is NewDuring propofol sedation, activation on functional magnetic resonance imaging in higher cognitive areas, such as semantic and phonologic processing, is abolished with deep sedation and only partially suppressed with light sedationActivation related to lower sensory processing continues with deep and light sedationBackground Elucidating networks u...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Impact of the World Health Organization Surgical Safety Checklist on Patient Safety
The incidence of surgical complications has remained largely unchanged over the past two decades. Inherent complexity in surgery, new technology possibilities, increasing age and comorbidity in patients may contribute to this. Surgical safety checklists may be used as some of the tools to prevent such complications. Use of checklists may reduce critical workload by eliminating issues that are already controlled for. The global introduction of the World Health Organization Surgical Safety Checklist aimed to improve safety in both anesthesia and surgery and to reduce complications and mortality by better teamwork, communicat...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Central Venous Catheter in the Internal Mammary Vein
(Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Giant T-wave Inversions in Apical Hypertrophic Cardiomyopathy
(Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Femoral Vein Thrombus Diagnosed during Ultrasound-guided Femoral Nerve Catheter Placement
(Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Short-term Physiologic Consequences of Regional Pulmonary Vascular Occlusion in Pigs
Editor ’s PerspectiveWhat We Already Know about This TopicAfter pulmonary artery occlusion (mimicking a pulmonary embolism), perfusion is redistributed to the rest of the lung tissue, but the distribution of ventilation is uncertain.What This Article Tells Us That Is NewData from anesthetized pigs (uninjured lungs) indicate that the perfusion is redistributed as suspected. Similarly, ventilation is redistributed from nonperfused to perfused lung tissue. This limits the increase in dead space and is accompanied by less density in the occluded lung.Background Acute unilateral pulmonary arterial occlusion causes ventila...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Clerihews for Chloroform
A Clerihew is a four-line comic poem with a rigid rhyming scheme, aabb, but no metric requirements. This poetic form was invented by E. C. (Edmund Clerihew) Bentley (1875 –1956), British humorist and author. Bentley’s Clerihews always began with the name of a famous person or character to create a rhyming challenge. The remaining three lines “roasted” the figure, sometimes in a historical context. If Bentley hoped he was inventing a poetic form to replace the limerick, he was unsuccessful, since most anesthesiologists have never heard of a Clerihew. I became aware of them when I was loaned a delight...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia
Conclusions This study shows that low-dose (30-mg) dextromethorphan is antihyperalgesic in humans on the areas of primary and secondary hyperalgesia and reverses peripheral and central neuronal sensitization. Because dextromethorphan had no intrinsic antinociceptive effect in acute pain on healthy skin,N-methyl-d-aspartate receptor may need to be sensitized by pain for dextromethorphan to be effective. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Foramen Magnum Stenosis and Spinal Cord Compression in Achondroplasia
(Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Measuring Childbirth Outcomes Using Administrative and Birth Certificate Data
Conclusions Maternal and newborn outcomes should be jointly reported because hospital rates of maternal morbidity and newborn morbidity are poorly correlated. This can be done using a childbirth composite measure alongside separate measures of maternal and newborn outcomes. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Measuring What Matters to Moms Most
“[C]urrently, the field of obstetric anesthesiology is bereft of useful quality measures.” (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model
Editor ’s PerspectiveWhat We Already Know about This TopicFor most bacterial pneumonia, the lung interstitium is considered to be the site of infection, and adequate antibiotic concentrations are important for drug effectDespite systemic antibiotic therapy, therapeutic failure is common, perhaps due to poor lung penetration, and resulting low interstitial space fluid antibiotic concentrationsIncreasing systemic antibiotic doses in order to increase interstitial space fluid antibiotic concentrations could lead to toxicities such as nephrotoxicityWhat This Article Tells Us That Is NewIn a mechanically ventilated health...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

The Unappreciated Role of Carbon Dioxide in Ventilation/Perfusion Matching
“Much of the emphasis in…gas exchange physiology is oxycentric, and carbon dioxide is often neglected and…may be more important than oxygen in regulation.” (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty A Time Series Analysis
Conclusions A system-wide initiative combining guideline dissemination with audit and feedback was effective in significantly decreasing opioid prescriptions in populations undergoing total knee arthroplasty, while minimally impacting pain scores. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Imaging the Injured Lung: Mechanisms of Action and Clinical Use: Erratum
In the Online First article published on January 17, 2019, “Imaging the Injured Lung: Mechanisms of Action and Clinical Use” (Cereda M, Xin Y, Goffi A, Herrmann J, Kaczka DW, Kavanagh BP, Perchiazzi G, Yoshida T, Rizi RR: Anesthesiology 2019; doi: 10.1097/ALN.0000000000002583. [Epub ahead of print]), the Research Support section does not acknowledge one of the grants that supported the work of Dr. Cereda (grant No. R01HL137389), and grant No. RO1HL139066 was awarded to Dr. Rizi, Dr. Cereda, and Mr. Xin (not Dr. Xin). The Research Support section should read as follows: “This work was supported in part by ...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid
Conclusions High dose ABP-700 infusions produce involuntary muscle movements and seizures in Beagle dogsvia distinct mechanisms. CPM-acid inhibits both GABAA and glycine receptors at the high (~100 × clinical) plasma concentrations achieved during the dog studies, providing a plausible mechanism for the seizures. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Point of Care Ultrasound to Identify Diaphragmatic Dysfunction after Thoracic Surgery
Conclusions Point of care ultrasound can be used to evaluate postoperative diaphragmatic function. On the first postoperative day, diaphragmatic dysfunction was less common after video-assisted than after the thoracotomic surgery and is associated with postoperative pulmonary complications. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

If You Thought That Night Float Solved Everything, Keep Dreaming
“[N]ight float can have negative effects on [resident] sleep and thus is less of a magic bullet than some may have thought.” (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Anesthesiology Resident Night Float Duty Alters Sleep Patterns An Observational Study
Editor ’s PerspectiveWhat We Already Know about This TopicNight float is one mechanism for fulfilling resident call responsibilities while avoiding prolonged clinical care that violates duty hoursWhat This Article Tells Us That Is NewIn anesthesiology residents conducting six consecutive nights of clinical care, three nights of recovery did not appear to restore normal sleep architecture, raising questions about this practiceBackground Residency programs utilize night float systems to adhere to duty hour restrictions; however, the influence of night float on resident sleep has not been described. The study aim was to...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Hepatitis C Contamination of Medication Vials Accessed with Sterile Needles and Syringes
Conclusions Hepatitis C virus can be transferred into commonly used medications when using sterile single-use needles and syringes where it remains viable for several days. Furthermore, cleaning the vial diaphragm with 70% isopropyl alcohol is not sufficient to eliminate the risk of hepatitis C virus infectivity. This highlights the potential risks associated with sharing medications between patients. (Source: Anesthesiology)
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Cross-talk between Human Spinal Cord μ-opioid Receptor 1Y Isoform and Gastrin-releasing Peptide Receptor Mediates Opioid-induced Scratching Behavior
Editor ’s PerspectiveWhat We Already Know about This TopicThe spinal administration of opioids can cause intense pruritisInteractions between specific μ-opioid receptor isoforms and the gastrin releasing peptide receptor in spinal tissues likely mediate morphine-induced pruritusWhat This Article Tells Us That Is NewHuman spinal cord tissue expresses the 1Y isoform of the μ-opioid receptor, and that isoform functionally interacts with the gastrin releasing peptide receptor to cause cellular calcium influxBlocking interactions between the 1Y isoform and the gastrin releasing peptide receptor does not reduce opioi...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research