Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management
This article reviews the outcomes and shortcomings of recent U.S. opioid policies and strategies that focus primarily or exclusively on reducing or eliminating opioid prescribing. It introduces concepts of a prescription opioid ecosystem and opioid pool, and it discusses how the pool can be influenced by supply-side, demand-side, and opioid returns factors. It illuminates pressing policy needs for an opioid ecosystem that enables proper opioid stewardship, identifies associated responsibilities, and emphasizes the necessity of making opioid returns as easy and common as opioid prescribing, in order to minimize the size of ...
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Acute Kidney Injury and Intraoperative Hypotension in Children: More Questions than Answers
“Kiddie kidneys are not little adult kidneys.” (Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Can We Finally Take the “V E ” Out of THRIVE?
“[There are] limited data on carbon dioxide clearance during high-flow apneic oxygenation.” (Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Fibrinolysis and Trauma Outcomes
Supplemental Digital Content is available in the text. (Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

A Beautiful Friendship —and a Lesson about Friends and Colleagues: A Classic Partnership Revisited
David Warner, M.D., and Michael Todd, M.D., first met in 1985. They began working together at the University of Iowa (Iowa City, Iowa) a year later with a shared interest in both laboratory and clinical neuroscience —and in the operative care of neurosurgical patients. That collaboration has now lasted for 35 yr, resulting in more than 70 joint publications. More importantly, they have had the privilege of working together with close to 1,000 colleagues from around the world, in a dozen medical specialties. T heir careers are an example of what can be accomplished by friendship, mutual commitment, persistence, and a will...
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Anesthesiology
(Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

No Humbug Here —Celebrating Ether Day in the Spirit of J. C. Warren
For the fiftieth anniversary of Ether Day, J. Collins Warren addressed the American Surgical Association in 1897 about the “Influence of Anaesthesia on the Surgery of the Nineteenth Century.” At first glance, it may appear that the attending surgeon from October 16, 1846, John Collins Warren, M.D. (bottom right), was posthumously presenting a spirited speech four decades after his death. Upon closer inspection, the reader learns that J. Collins Warren, M.D. (bottom left), the grandson of the elder Dr. Warren, is reflecting on his family legacy and reminding fellow surgeons that surgical advancement should “excite our...
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Science, Medicine, and the Anesthesiologist
Key Papers from the Most Recent Literature Relevant to Anesthesiologists (Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Gauging the Herrick-Pender Thermistor: Marvelous Monitoring, from Open Fridge to Open Heart
After completing his World War II Navy assignment, John William Pender, M.D. (1912 to 2002,lower right), returned in 1946 to anesthesiology training at Mayo Clinic. While trialing hypothermia protocols in cardiac surgery, Pender and his team used thermistors from electric refrigerators ( “fridges”)—modern marvels of the mid-twentieth-century kitchen. By encapsulating metallic oxide beads in epoxy, these “thermal resistors” were more responsive and less toxic than mercury-based thermometers. Unfortunately, these “resistors” lacked a proper temperature gauge. Pender reac hed out to Julia F. Herrick, Ph.D. (uppe...
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Somnoforme Quickens the Pulse, then Slumbers into Oblivion
In search of the ideal inhalational anesthetic, a French dental professor, Georges Rolland of Bordeaux, developed Somnoforme in 1901. Chemist Alfred Rousseau, also of Bordeaux, then produced it in luminous green bottles labeled with mystical raised letters (center). In the 1860s, the popular A.C.E. mixture had combined the best anesthetic properties of alcohol, chloroform, and ether. Similarly, Somnoforme blended ethyl chloride (60%), methyl chloride (35%), and ethyl bromide (5%) to play up the three agents ’ respective strengths—anesthetic maintenance, rapid induction, and postoperative analgesia. When Rolland self-in...
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Instructions for Obtaining A nesthesiology Continuing Medical Education (CME) Credit
(Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Fibrinolysis Transitions: Adverse Outcomes in Trauma
Complex Information for Anesthesiologists Presented Quickly and Clearly (Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Anesthesiology
(Source: Anesthesiology)
Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

This Month in Anesthesiology
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Source: Anesthesiology - December 15, 2021 Category: Anesthesiology Source Type: research

Burnout in Anesthesiologists: Reply
(Source: Anesthesiology)
Source: Anesthesiology - November 10, 2021 Category: Anesthesiology Source Type: research