American Journal of Physiology. Gastrointestinal and Liver Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Effects of Corticotropin-Releasing Hormone on Gastric Electrical Activity and Sensorimotor Function in Healthy Volunteers: A Double-blinded Crossover Study
Am J Physiol Gastrointest Liver Physiol. 2024 Feb 20. doi: 10.1152/ajpgi.00298.2023. Online ahead of print.ABSTRACTBiopsychosocial factors are associated with disorders of gut brain interaction and exacerbate gastrointestinal symptoms. The mechanisms underlying pathophysiological alterations of stress remain unclear. Corticotropin-releasing hormone (CRH) is a central regulator of the hormonal stress response and has diverse impact on different organ systems. The aim of the present study was to investigate the effects of peripheral CRH infusion on meal-related gastrointestinal symptoms, gastric electrical activity and gastr...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 20, 2024 Category: Physiology Authors: I-Hsuan Huang Jolien Schol Stefan Calder Armen A Gharibans Karen Van den Houte Annelies Verheyden Bert Broeders Florencia Carbone Gregory O'Grady Jan Tack Source Type: research

Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine non-alcoholic steatohepatitis
Am J Physiol Gastrointest Liver Physiol. 2024 Feb 20. doi: 10.1152/ajpgi.00264.2023. Online ahead of print.ABSTRACTRecently, the development of non-alcoholic steatohepatitis (NASH) in common strains of pigs has been achieved using a diet high in saturated fat, fructose, cholesterol and cholate and deficient in choline and methionine. The aim of the present work was to characterize the hepatic and plasma lipidomic changes that accompany the progression of NASH and its reversal by switching pigs back to a chow diet. One month of this extreme steatotic diet was sufficient to induce porcine NASH. The lipidomic platform using l...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 20, 2024 Category: Physiology Authors: Luis V Herrera-Marcos Roberto Mart ínez-Beamonte Carmen Arnal Cristina Barranquero Juan J Puente-Lanzarote Jos é M Lou-Bonafonte Gonzalo Gonzalo-Romeo Gabriele Mocciaro Benjamin Jenkins Joaquin C Surra Mar ía J Rodríguez-Yoldi V íctor Alastrué-Vera Source Type: research

Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
Am J Physiol Gastrointest Liver Physiol. 2024 Feb 13. doi: 10.1152/ajpgi.00126.2023. Online ahead of print.ABSTRACTGenotoxic agents like doxorubicin (DXR) can cause damage to the intestines that can be ameliorated by fasting. How fasting is protective and the optimal timing of fasting and refeeding remain unclear. Here, our analysis of fasting/refeeding-induced global intestinal transcriptional changes revealed metabolic shifts and implicated the cellular energetic hub mTORC1 in protecting from DXR-induced DNA damage. Our analysis of specific transcripts and proteins in intestinal tissue and tissue extracts showed that fas...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 13, 2024 Category: Physiology Authors: Kali Deans-Fielder Timothy Wu Thanh Nguyen Sarah To Yang-Zhe Huang Steven J Bark Jason C Mills Noah F Shroyer Source Type: research

A Mathematical Model of ENaC and Slc26a6 Regulation by CFTR in Salivary Gland Ducts
Am J Physiol Gastrointest Liver Physiol. 2024 Feb 13. doi: 10.1152/ajpgi.00168.2023. Online ahead of print.ABSTRACTCystic Fibrosis (CF) is a genetic disease caused by the mutations of CFTR, the cystic fibrosis transmembrane conductance regulator gene. Cftr is a critical ion channel expressed in the apical membrane of mouse salivary gland striated duct cells. Although Cftr is primarily a Cl- channel, its knockout leads to higher salivary Cl- and Na+concentrations and lower pH. Mouse experiments show that the activation of Cftr up-regulates ENaC (Epithelial Na+Channel) protein expression level and Slc26a6 (a 1Cl- : 2HCO3- ex...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 13, 2024 Category: Physiology Authors: Shan Su Amanda Wahl John Rugis Vinod Suresh David Yule James Sneyd Source Type: research

Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells
CONCLUSION: Our study discovered that anthocyanins could improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7, thereby affecting HSC ferroptosis levels.PMID:38290991 | DOI:10.1152/ajpgi.00227.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 30, 2024 Category: Physiology Authors: Likun Liu Jinhui Du Haiqing Fan Yue Yu Yilin Luo Fang Gu Hui Yu Xin Liao Source Type: research

Role of mechanoregulation in mast cell-mediated immune inflammation of the smooth muscle in pathophysiology of esophageal motility disorders
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 30. doi: 10.1152/ajpgi.00258.2023. Online ahead of print.ABSTRACTMajor esophageal disorders involve obstructive transport of bolus to the stomach, causing symptoms of dysphagia and impaired clearing of the refluxed gastric contents. These may occur due to mechanical constriction of the esophageal lumen or loss of relaxation associated with deglutitive inhibition, as in achalasia-like disorders. Recently, immune inflammation has been identified as an important cause of esophageal strictures and the loss of inhibitory neurotransmission. These disorders are also associated wit...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 30, 2024 Category: Physiology Authors: Raj K Goyal Satish Rattan Source Type: research

NADPH oxidase 1 promotes hepatic steatosis in obese mice and is abrogated by augmented skeletal muscle mass
Conclusion: Taken together, these data suggest hypermuscularity attenuates Srebp1 expression in db/db mice through a NOX1-dependent mechanism.PMID:38258487 | DOI:10.1152/ajpgi.00153.2023 (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 23, 2024 Category: Physiology Authors: Sebastian Larion Caleb A Padgett James D Mintz Jennifer A Thompson Joshua T Butcher Eric J Belin de Chantem èle Stephen Haigh Sandeep Khurana David J Fulton David W Stepp Source Type: research

Gastrointestinal dysmotility in rodent models of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 23. doi: 10.1152/ajpgi.00225.2023. Online ahead of print.ABSTRACTMultiple studies describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop Parkinson's disease (PD). These prodromal dysfunctions comprise a wide array of autonomic issues, including severe gastrointestinal (GI) motility disorders such as dysphagia, delayed gastric emptying and chronic constipation. Indeed, strong evidence from studies in humans and in animal models suggests that the GI tract and its neural, mainly vagal, connection to the central nervous s...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 23, 2024 Category: Physiology Authors: Carolina Pellegrini R Alberto Travagli Source Type: research

Inhibition of visceral adipose tissue-derived pathogenic signals by activation of adenosine A < sub > 2A < /sub > R improves hepatic and cardiac dysfunction of NASH mice
This study explores the effects of four-weeks A2AR agonist PSB0777 treatment on the VAT-driven pathogenic signals in hepatic and cardiac dysfunction of non-alcoholic steatohepatitis (NASH) obese mice. Among NASH mice with cardiac dysfunction, simultaneous decrease in the A2AR、AC、cAMP and PKA levels were observed in VAT, liver, and heart. PSB0777 treatment significantly restores AC、cAMP, PKA, HSL levels, decreased SREBP-1/FASN, MCP-1 and CD68 levels, reduces infiltrated CD11b+F4/80+ cells and adipogenesis in VAT of NASH+PSB0777 mice. The changes in VAT were accompanied by the suppression of hepatic and cardiac lipogen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 22, 2024 Category: Physiology Authors: Chia-Chang Huang Hsiao-Yun Yeh Roger Lin Tsai-Ling Liao Hsiao-Chin Shen Ying-Ying Yang Han-Chieh Lin Source Type: research