American Journal of Physiology. Gastrointestinal and Liver Physiology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 12, 2023 Category: Physiology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 12, 2023 Category: Physiology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 12, 2023 Category: Physiology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 12, 2023 Category: Physiology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - December 5, 2023 Category: Physiology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Seladelpar combined with complementary therapies improves fibrosis, inflammation and liver injury in a mouse model of nonalcoholic steatohepatitis
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 28. doi: 10.1152/ajpgi.00158.2023. Online ahead of print.ABSTRACTSeladelpar, a selective PPARδ agonist, improves markers of hepatic injury in human liver diseases, but histological improvement of nonalcoholic steatohepatitis (NASH) and liver fibrosis has been challenging with any single agent. To discover how complimentary agents could work with seladelpar to achieve optimal outcomes, this study evaluated a variety of therapeutics (alone and in combination) in a mouse model of NASH. Mice on a high fat Amylin Liver NASH (AMLN) diet were treated for 12 weeks with seladelpar,...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 28, 2023 Category: Physiology Authors: Yun-Jung Choi Jeffrey D Johnson Jin-Ju Lee Jiangao Song Marcy Matthews Marc K Hellerstein Charles A McWherter Source Type: research
Repurposing dried blood spot (DBS) device technology to examine bile acid profiles in human dried fecal spot (DFS) samples
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 28. doi: 10.1152/ajpgi.00188.2023. Online ahead of print.ABSTRACTDried blood spot (DBS) analysis has existed for >50 years, but application of this technique to fecal analysis remains limited. To address whether dried fecal spots (DFS) could be used to measure fecal bile acids, we collected feces from five subjects for each of the following cohorts: i) healthy individuals, ii) individuals with diarrhea, and iii) Clostridioides difficile-infected patients. Homogenized fecal extracts were loaded onto quantitative DBS (qDBS) devices, dried overnight, and shipped to the bioa...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 28, 2023 Category: Physiology Authors: Melinda A Engevik Santosh Thapa Ian Lillie Mary Beth Yacyshyn Bruce Yacyshyn Andrew J Percy Donald Chace Thomas D Horvath Source Type: research
Seladelpar combined with complementary therapies improves fibrosis, inflammation and liver injury in a mouse model of nonalcoholic steatohepatitis
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 28. doi: 10.1152/ajpgi.00158.2023. Online ahead of print.ABSTRACTSeladelpar, a selective PPARδ agonist, improves markers of hepatic injury in human liver diseases, but histological improvement of nonalcoholic steatohepatitis (NASH) and liver fibrosis has been challenging with any single agent. To discover how complimentary agents could work with seladelpar to achieve optimal outcomes, this study evaluated a variety of therapeutics (alone and in combination) in a mouse model of NASH. Mice on a high fat Amylin Liver NASH (AMLN) diet were treated for 12 weeks with seladelpar,...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 28, 2023 Category: Physiology Authors: Yun-Jung Choi Jeffrey D Johnson Jin-Ju Lee Jiangao Song Marcy Matthews Marc K Hellerstein Charles A McWherter Source Type: research
Repurposing dried blood spot (DBS) device technology to examine bile acid profiles in human dried fecal spot (DFS) samples
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 28. doi: 10.1152/ajpgi.00188.2023. Online ahead of print.ABSTRACTDried blood spot (DBS) analysis has existed for >50 years, but application of this technique to fecal analysis remains limited. To address whether dried fecal spots (DFS) could be used to measure fecal bile acids, we collected feces from five subjects for each of the following cohorts: i) healthy individuals, ii) individuals with diarrhea, and iii) Clostridioides difficile-infected patients. Homogenized fecal extracts were loaded onto quantitative DBS (qDBS) devices, dried overnight, and shipped to the bioa...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 28, 2023 Category: Physiology Authors: Melinda A Engevik Santosh Thapa Ian Lillie Mary Beth Yacyshyn Bruce Yacyshyn Andrew J Percy Donald Chace Thomas D Horvath Source Type: research
Seladelpar combined with complementary therapies improves fibrosis, inflammation and liver injury in a mouse model of nonalcoholic steatohepatitis
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 28. doi: 10.1152/ajpgi.00158.2023. Online ahead of print.ABSTRACTSeladelpar, a selective PPARδ agonist, improves markers of hepatic injury in human liver diseases, but histological improvement of nonalcoholic steatohepatitis (NASH) and liver fibrosis has been challenging with any single agent. To discover how complimentary agents could work with seladelpar to achieve optimal outcomes, this study evaluated a variety of therapeutics (alone and in combination) in a mouse model of NASH. Mice on a high fat Amylin Liver NASH (AMLN) diet were treated for 12 weeks with seladelpar,...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - November 28, 2023 Category: Physiology Authors: Yun-Jung Choi Jeffrey D Johnson Jin-Ju Lee Jiangao Song Marcy Matthews Marc K Hellerstein Charles A McWherter Source Type: research
