Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: Am J Respir Cell Mol... - November 17, 2023 Category: Respiratory Medicine Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
InfluenZing Lung Fibrosis: Reinforcing Endothelial Surface Expression of S1PR1 to Attenuate Post-ARDS Lung Remodeling
Am J Respir Cell Mol Biol. 2023 Nov 15. doi: 10.1165/rcmb.2023-0372ED. Online ahead of print.NO ABSTRACTPMID:37967249 | DOI:10.1165/rcmb.2023-0372ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - November 15, 2023 Category: Respiratory Medicine Authors: Georgios Kiliaris Elie El Agha Source Type: research
InfluenZing Lung Fibrosis: Reinforcing Endothelial Surface Expression of S1PR1 to Attenuate Post-ARDS Lung Remodeling
Am J Respir Cell Mol Biol. 2023 Nov 15. doi: 10.1165/rcmb.2023-0372ED. Online ahead of print.NO ABSTRACTPMID:37967249 | DOI:10.1165/rcmb.2023-0372ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - November 15, 2023 Category: Respiratory Medicine Authors: Georgios Kiliaris Elie El Agha Source Type: research
Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: Am J Respir Cell Mol... - November 7, 2023 Category: Respiratory Medicine Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research
Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: Am J Respir Cell Mol... - November 7, 2023 Category: Respiratory Medicine Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research
Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: Am J Respir Cell Mol... - November 7, 2023 Category: Respiratory Medicine Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research
Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: Am J Respir Cell Mol... - November 7, 2023 Category: Respiratory Medicine Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research
Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: Am J Respir Cell Mol... - November 7, 2023 Category: Respiratory Medicine Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research
