February Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2024 Feb;70(2):iii. doi: 10.1165/rcmb.70i2RedAlert.NO ABSTRACTPMID:38299795 | DOI:10.1165/rcmb.70i2RedAlert (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Source Type: research
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking
Am J Respir Cell Mol Biol. 2024 Feb;70(2):140-143. doi: 10.1165/rcmb.2023-0335LE.NO ABSTRACTPMID:38299796 | DOI:10.1165/rcmb.2023-0335LE (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Reem El Kabbout Nabil Azhar Sandra Breuils-Bonnet Sandra Martineau Vinod Krishna Shanker Kalyana-Sundaram Olivier Boucherat Steeve Provencher S ébastien Bonnet Fran çois Potus Source Type: research
Pulmonary Veno-Occlusive Disease and Pulmonary Fibrosis in a Family with < em > EIF2AK4 < /em > Pathogenic Variants
Am J Respir Cell Mol Biol. 2024 Feb;70(2):143-145. doi: 10.1165/rcmb.2023-0166LE.NO ABSTRACTPMID:38299797 | DOI:10.1165/rcmb.2023-0166LE (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Kelly Vetel M élanie Eyries Laurent Savale Caroline Kanengiesser Raphael Borie Marc Humbert David Montani Source Type: research
Farnesoid X Receptor Protects Murine Lung Against IL-6-promoted Ferroptosis Induced by Poly(I:C)
In this study, a intratracheal instillation of poly(I:C) with or without IL-6 neutralizing antibody model combined with metabonomics, transcriptomics and so on to explore the underlying molecular mechanisms of IL-6-exacerbated lung injury. We found that poly(I:C) increased IL-6 level, and the up-regulated IL-6 further induced lung ferroptosis, especially in AT2 cells. Meanwhile, the lung regeneration was impaired. Mechanistically, metabolomics analysis showed that poly(I:C) significantly decreased glycolytic metabolites and increased bile acid intermediate metabolites that inhibited the bile acid nuclear receptor farnesoid...
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Dongmin Yang Hongbiao Liang Xiangrui Zhu Bochuan Li Chun Li Guizimeng Hu Xing Du Guohui Dang Yuwei Song Xiaolong Ma Peng Zhang Tianqi Chen Bo Liu Li Yan Chunshui Pan Kai Sun Xinmei Huo Yingmei Feng Xian Wang Ding Ai Jingyan Han Juan Feng Source Type: research
Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:38301257 | DOI:10.1165/rcmb.2023-0429OC (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Faraaz A Shah Harinath Bahudhanapati Mao Jiang Mohammadreza Tabary Rick van der Geest Nathanial J Tolman Megan Kochin Zeyu Xiong Nameer Al-Yousif Khaled Sayed Panayiotis V Benos Kristen Raffensperger John Evankovich Matthew D Neal Mark E Snyder Oliver Eic Source Type: research
Unraveling a Key Molecular Player Governing Pulmonary Alveolar Development
Am J Respir Cell Mol Biol. 2024 Feb 1. doi: 10.1165/rcmb.2024-0025ED. Online ahead of print.NO ABSTRACTPMID:38301261 | DOI:10.1165/rcmb.2024-0025ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Shihang Ding Shinji Deguchi Taeyoon Kim Source Type: research
Unveiling an Important New Cell Type in the Lung: Microfold Cells
Am J Respir Cell Mol Biol. 2024 Feb 1. doi: 10.1165/rcmb.2024-0002ED. Online ahead of print.NO ABSTRACTPMID:38301262 | DOI:10.1165/rcmb.2024-0002ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: SeungHye Han Source Type: research
Ddx5 Targeted Epigenetic Modification of Pericytes in Pulmonary Hypertension Following Intrauterine Growth Restriction
Am J Respir Cell Mol Biol. 2024 Feb 1. doi: 10.1165/rcmb.2023-0244OC. Online ahead of print.ABSTRACTNewborns with intrauterine growth restriction (IUGR) have a higher likelihood of developing pulmonary arterial hypertension (PAH) in adulthood. While there is increasing evidence suggesting that pericytes play a role in regulating myofibroblast transdifferentiation and angiogenesis in malignant and cardiovascular diseases, their involvement in the pathogenesis of IUGR-related PH and the underlying mechanisms remain incompletely understood. To address this issue, a study was conducted utilizing a Sprague-Dawley (SD) rat model...
Source: Am J Respir Cell Mol... - February 1, 2024 Category: Respiratory Medicine Authors: Chengcheng Hang Lu Zu Xiaofei Luo Yu Wang Lingling Yan Ziming Zhang Kaixing Le Yajie Huang Lixia Ye Yuhan Ying Kewei Chen Xuefeng Xu Qiannan Lv Lizhong Du Source Type: research
Alveolar Epithelial Cell Dysfunction in IPF Linked to Lipid Alterations: Therapeutic Implications
Am J Respir Cell Mol Biol. 2024 Jan 25. doi: 10.1165/rcmb.2023-0432ED. Online ahead of print.NO ABSTRACTPMID:38271680 | DOI:10.1165/rcmb.2023-0432ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - January 25, 2024 Category: Respiratory Medicine Authors: Francesca Polverino Ana Mora Source Type: research
FTO Deficiency Alleviate LPS-induced ALI by TXNIP/NLPR3-mediated Alveolar Epithelial Cell Pyroptosis
This study aimed to examine the role and mechanism of the m6A demethylase FTO in lipopolysaccharide (LPS)-induced ALI. Lung epithelial FTO knockout mice and FTO knockdown/overexpression A549 cell lines were constructed to evaluate the effects of FTO on ALI. Bioinformatics analysis and a series of in vivo and in vitro assays were used to examine the mechanism of FTO regulation. Rescue assays were conducted to examine whether the impact of FTO on ALI depended on the TXNIP/NLRP3 pathway. In LPS-induced ALI, RNA m6A modification levels were upregulated, and FTO expression was downregulated. In vivo, lung epithelial FTO knockou...
Source: Am J Respir Cell Mol... - January 25, 2024 Category: Respiratory Medicine Authors: Wei-Ming Xie Wei Su Xin-Yu Liu Junhao Zhou Min Wang Yuchang Wang Wei Wang Xiangjun Bai Zhanfei Li Tianyu Li Source Type: research
Drebrin Is Required for Myosin-facilitated Actin Cytoskeletal Remodeling During Pulmonary Alveolar Development
Am J Respir Cell Mol Biol. 2024 Jan 25. doi: 10.1165/rcmb.2023-0229OC. Online ahead of print.ABSTRACTAlveolar septation increases gas-exchange surface area and requires coordinated cytoskeletal rearrangement in lung fibroblasts (LF), to balance the demands of contraction and cell migration. We hypothesized that drebrin (DBN), a modulator of the actin cytoskeleton in neuronal dendrites, regulates the remodeling of the LF-cytoskeleton. Using mice bearing a transgelin-Cre (TGCre) targeted deletion of Dbn in pulmonary fibroblasts and pericytes, we examined alterations in alveolar septal outgrowth, LF spreading and migration, a...
Source: Am J Respir Cell Mol... - January 25, 2024 Category: Respiratory Medicine Authors: Stephen E McGowan Nikolas Gilfanov Mohanish K Chandurka Jonathan A Stiber Sangyoon J Han Source Type: research
Getting the Timing Right: Controlling BCL-2 Inhibition as an Anti-Fibrotic Therapy
Am J Respir Cell Mol Biol. 2024 Jan 23. doi: 10.1165/rcmb.2023-0436ED. Online ahead of print.NO ABSTRACTPMID:38259233 | DOI:10.1165/rcmb.2023-0436ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - January 23, 2024 Category: Respiratory Medicine Authors: Joseph C Cooley Elizabeth F Redente Source Type: research
S1PR2: A Fulcrum in the Balance of Type 1 and Type 2 Responses During Sepsis-induced Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Jan 16. doi: 10.1165/rcmb.2023-0433ED. Online ahead of print.NO ABSTRACTPMID:38226863 | DOI:10.1165/rcmb.2023-0433ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - January 16, 2024 Category: Respiratory Medicine Authors: Philip A Verhoef Source Type: research
Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0157OC. Online ahead of print.ABSTRACTBronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations of airways and the distal lung. Although clinical studies have shown striking associations between antenatal stress and BPD, little is known about underlying pathogenetic mechanisms. Whether dysanapsis, the concept of discordant growth of airways and parenchyma, contributes to late respiratory disease due to antenatal stress is unknown. We hypothe...
Source: Am J Respir Cell Mol... - January 11, 2024 Category: Respiratory Medicine Authors: Elizabeth A McGinn Elisa Bye Tania Gonzalez Alexander Sosa Jill Bilodeaux Gregory Seedorf Bradford J Smith Steven H Abman Erica W Mandell Source Type: research
Characterization of Commercially Available Human Primary Alveolar Epithelial Cells
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0320MA. Online ahead of print.ABSTRACTIn vitro lung research requires appropriate cell culture models that adequately mimic in vivo structure and function. Previously, researchers have extensively utilized commercially available and easily expandable A549 and NCI-H441 cells which replicate some yet not all features of alveolar epithelial cells. Specifically, these cells are often restricted by terminally altered expression while lacking important alveolar epithelial characteristics. Of late, human primary alveolar epithelial cells (hPAEpC) have become commercia...
Source: Am J Respir Cell Mol... - January 11, 2024 Category: Respiratory Medicine Authors: Christopher J Herbst Elena Lopez-Rodriguez Vladimir Gluhovic Sabrina Schulz Raphael Brandt Sara Timm Jubilant Abledu Juliana Falivene Peter Pennitz Holger Kirsten Geraldine Nouailles Martin Witzenrath Matthias Ochs Wolfgang M Kuebler Source Type: research
