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The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway
Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effective... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 17, 2022 Category: Allergy & Immunology Authors: Xueying Li, Zhaoqing Han, Feng Wang and Jianou Qiao Tags: Research Source Type: research

Allergic rhinitis, allergic contact dermatitis and disease comorbidity belong to separate entities with distinct composition of T-cell subsets, cytokines, immunoglobulins and autoantibodies
Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent allergic diseases and have significant impacts on patients ’ daily life. Despite many studies on AR or ACD have been conducted separate... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 11, 2022 Category: Allergy & Immunology Authors: Wenjia Chai, Xuyi Zhang, Meixiong Lin, Zhuo Chen, Xiaolin Wang, Changqing Wang, Aoyan Chen, Caisheng Wang, Hongwu Wang, Honghong Yue and Jingang Gui Tags: Research Source Type: research

The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopi... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 3, 2022 Category: Allergy & Immunology Authors: Nabeel H. Akhtar, Touraj Khosravi-Hafshejani, Daud Akhtar, Gurbir Dhadwal and Amin Kanani Tags: Case report Source Type: research

Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population
Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 31, 2022 Category: Allergy & Immunology Authors: Han-Ki Park, Seok-Ju Yoo, Taek Soo Kim, Byung-Keun Kim, Sekyung Jang, Sung Yeon Kim and Kwan Lee Tags: Research Source Type: research

Lessons learned in allergy and immunology training: a survey analysis
This study aims to id... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 31, 2022 Category: Allergy & Immunology Authors: Chloe Cyr, Michael Cyr, Jaclyn Quirt and Lori Connors Tags: Research Source Type: research

Modified oral food challenge protocol approach in the diagnosis of Food Protein-Induced Enterocolitis Syndrome
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE mediated food allergy most commonly presenting in infants. The most common food triggers include soy, cow ’s milk and grains. Symptoms may includ... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 31, 2022 Category: Allergy & Immunology Authors: Jessica Sultafa, Lundy McKibbon, Hannah Roberts, Jumana Sarraj and Harold Kim Tags: Short report Source Type: research

The frequencies of peripheral blood CD5+CD19+ B cells, CD3 −CD16+CD56+ NK, and CD3+CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder
Multiple sclerosis (MS) and neuromyelitis optica syndrome disease (NMOSD) are inflammatory diseases of the central nervous system. The pathogenesis and treatments for these two conditions are very different. N... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 14, 2022 Category: Allergy & Immunology Authors: Leila Khani, Mir Hadi Jazayeri, Reza Nedaeinia, Mahmood Bozorgmehr, Seyed Masood Nabavi and Gordon A. Ferns Tags: Research Source Type: research

Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series
Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuat... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 13, 2022 Category: Allergy & Immunology Authors: Marcus Maurer, Markus Magerl, Emel Ayg ören-Pürsün, Konrad Bork, Henriette Farkas, Hilary Longhurst, Sorena Kiani‑Alikhan, Laurence Bouillet, Isabelle Boccon-Gibod, Mauro Cancian, Andrea Zanichelli and David Launay Tags: Case report Source Type: research

Role of airway smooth muscle cell phenotypes in airway tone and obstruction in guinea pig asthma model
Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile agonists as histamine, or by indirect provoc... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 11, 2022 Category: Allergy & Immunology Authors: Mayra D. Álvarez-Santos, Marisol Álvarez-González, Elizabeth Eslava-De-Jesus, Angel González-López, Ivonne Pacheco-Alba, Yazmín Pérez-Del-Valle, Rodrigo Rojas-Madrid and Blanca Bazán-Perkins Tags: Research Source Type: research

Fatal liver mass rupture in a common-variable-immunodeficiency patient with probable nodular regenerating hyperplasia
Nodular regenerating hyperplasia (NRH) is the most common liver involvement in common variable immunodeficiency (CVID). Most patients are asymptomatic with gradually increasing alkaline phosphatase (ALP) and mild... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 7, 2022 Category: Allergy & Immunology Authors: Mongkhon Sompornrattanaphan, Ranista Tongdee, Chamard Wongsa, Anupop Jitmuang and Torpong Thongngarm Tags: Case report Source Type: research

What is the impact of birth weight corrected for gestational age on later onset asthma: a meta-analysis
Asthma is a common multifactorial disease affecting millions worldwide. The Barker hypothesis postulates an association between later onset disease risk and energy exposure in utero. Birth weight corrected for... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - January 4, 2022 Category: Allergy & Immunology Authors: Jingjing Wang, Zeyi Zhang and Ou Chen Tags: Review Source Type: research

Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in Spain
The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our g... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - December 29, 2021 Category: Allergy & Immunology Authors: Mar Guilarte, Anna Sala-Cunill, Mar ía Luisa Baeza, Rosario Cabañas, María Dolores Hernández, Ethel Ibañez, Carlos Hernando de Larramendi, Ramon Lleonart, Teófilo Lobera, Luis Marqués, Blanca Sáenz de San Pedro, Jaco Botha, Irmgard Andresen and Te Tags: Research Source Type: research

Failure of a single day metronidazole desensitization protocol, and success of a modified two-day protocol in an outpatient setting
True allergy to metronidazole, a common anti-infective in clinical practice, is rarely reported in the literature. In the case of Trichomonas, there are few alternatives to the nitrimidazole class of drugs, and t... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - December 28, 2021 Category: Allergy & Immunology Authors: Julia A. Cahill, Preena Simritpreet Sahota and Manstein Kan Tags: Case report Source Type: research

The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005 –2006
The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, sever... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - December 25, 2021 Category: Allergy & Immunology Authors: Song Li, Chu-Jin Zhao, Hong-Li Hua, Yu-Qin Deng and Ze-Zhang Tao Tags: Research Source Type: research

Malignancy and immune disorders in patients with hereditary angioedema
Hereditary angioedema (HAE) is an inherited condition manifesting as recurrent angioedema episodes which is caused by deficiency or dysfunction of C1 inhibitor. Although complement dysregulation has historical... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - December 19, 2021 Category: Allergy & Immunology Authors: Peter Stepaniuk and Amin Kanani Tags: Case Report Source Type: research