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Hypereosinophilic syndrome presenting as coagulopathy
Hypereosinophilic syndrome (HES) is an extremely uncommon group of disorders. It rarely presents with coagulopathy without cardiac involvement. (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 22, 2022 Category: Allergy & Immunology Authors: Kestutis Aukstuolis, Jocelyn J. Cooper, Katherine Altman, Anna Lang and Andrew G. Ayars Tags: Case report Source Type: research

Outcome of a de-labelling algorithm compared with results of penicillin ( β-lactam) allergy testing
Penicillin allergy labels frequently impede guideline-directed treatment with a penicillin or other β-lactam antibiotics. Despite presumed allergy, targeted questioning may indicate a low probability of sensit... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 22, 2022 Category: Allergy & Immunology Authors: Philipp Schr üfer, Johanna Stoevesandt and Axel Trautmann Tags: Research Source Type: research

Allergy-related outcomes and sleep-related disorders in adults: a cross-sectional study based on NHANES 2005 –2006
Epidemiological evidence between the sleep disorders and allergy-related outcomes is limited. (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 22, 2022 Category: Allergy & Immunology Authors: Yang Xi, Yu-Qin Deng, Shi-Ming Chen, Yong-Gang Kong, Yu Xu, Fen Li, Wo-Er Jiao, Gan Lu and Ze-Zhang Tao Tags: Research Source Type: research

Comparison of circulating fibrocytes from non-asthmatic patients with seasonal allergic rhinitis between in and out of pollen season samples
Allergic rhinitis is a risk factor for asthma development. In asthma, fibroblast progenitors, fibrocytes, are increased in the blood and bronchial mucosa following allergen exposure. These cells may play a rol... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 16, 2022 Category: Allergy & Immunology Authors: Marie- Ève Côté, Marie-Ève Boulay, Sophie Plante, Andréanne Côté, Jamila Chakir and Louis-Philippe Boulet Tags: Research Source Type: research

Intravenous immunoglobulins improve live birth rate among women with underlying immune conditions and recurrent pregnancy loss: a systematic review and meta-analysis
Intravenous immunoglobulin (IVIG) is increasingly used as a treatment for recurrent pregnancy loss (RPL) despite lack of clear evidence on efficacy. Recent data suggest IVIG might be more effective in a subgro... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 11, 2022 Category: Allergy & Immunology Authors: Denise H. J. Habets, Kim Pelzner, Lotte Wieten, Marc E. A. Spaanderman, Eduardo Villamor and Salwan Al-Nasiry Tags: Review Source Type: research

AstraZeneca ChAdOx1-S COVID-19 vaccine can be safely administered in patients with EDTA allergy
Immediate hypersensitivity reactions to COVID-19 vaccines have been postulated to be linked to their excipients, such as polyethylene glycol (PEG) in Pfizer Comirnaty, or polysorbate 80 and ethylenediaminetetr... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 10, 2022 Category: Allergy & Immunology Authors: Syed B. Ali, Griffith Perkins, Dongjae Ryoo, Maverick Lee, Matthew Tunbridge, Chino Yuson, William Smith, Pravin Hissaria and Thanh-Thao Le Tags: Case report Source Type: research

Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review
Non-infectious complications have become a major cause of morbidity and mortality in patients with Common Variable Immunodeficiency (CVID). The monitoring of patients with CVID prior to the development of non-... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 9, 2022 Category: Allergy & Immunology Authors: Erika Yue Lee, Stephen Betschel and Eyal Grunebaum Tags: Letter to the Editor Source Type: research

Growth in diagnosis and treatment of primary immunodeficiency within the global Jeffrey Modell Centers Network
Primary immunodeficiencies (PI), which include more than 450 single-gene inborn errors of immunity and may affect up to 1% of the population, are genetic disorders that impair the immune system. If not properly i... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 4, 2022 Category: Allergy & Immunology Authors: Jessica Quinn, Vicki Modell, Jordan S. Orange and Fred Modell Tags: Research Source Type: research

Identification of gene biomarkers with expression profiles in patients with allergic rhinitis
Allergic rhinitis (AR) is an upper respiratory tract inflammation disease caused by IgE-mediated reactions against inhaled allergens. The incidence of AR is significantly increasing throughout the world. Hence... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - March 4, 2022 Category: Allergy & Immunology Authors: Yun Hao, Boqian Wang, Jinming Zhao, Ping Wang, Yali Zhao, Xiangdong Wang, Yan Zhao and Luo Zhang Tags: Research Source Type: research

Rituximab and dupilumab improve eosinophilic granulomatosis with polyangiitis with multiple pulmonary thrombi
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by a necrotizing vasculitis with tissue and peripheral blood eosinophilia affecting small and medium-sized arteries, capillaries, and veins... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 26, 2022 Category: Allergy & Immunology Authors: Sei Adachi, Chiyako Oshikata, Takeshi Kaneko and Naomi Tsurikisawa Tags: Case Report Source Type: research

Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins
Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 23, 2022 Category: Allergy & Immunology Authors: Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu and Beata Derfalvi Tags: Case report Source Type: research

Activated phosphoinositide 3-kinase δ syndrome associated with nephromegaly, growth hormone deficiency, bronchiectasis: a case report
Activated phosphoinositide 3-kinase (PI3K) δ syndrome (APDS) is a rare form of primary immunodeficiency with 243 known cases reported in the literature. Known findings associated with the condition include rec... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 21, 2022 Category: Allergy & Immunology Authors: Megan Craig, Bob Geng, Kristen Wigby, Susan A. Phillips, Christine Bakhoum, John Naheedy and Mateja Cernelc-Kohan Tags: Case report Source Type: research

Telemedicine in allergy/immunology in the era of COVID-19: a Canadian perspective
In the era of COVID-19, utilization of telemedicine has dramatically increased. In addition to reduced travel times, patient expenses, and work or school days missed, telemedicine allows clinicians to provide ... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 21, 2022 Category: Allergy & Immunology Authors: Sarah Edgerley, Rongbo Zhu, Ariba Quidwai, Harold Kim and Samira Jeimy Tags: Research Source Type: research

Stellate ganglion block as an intervention in refractory eosinophilic granulomatosis with polyangiitis: a case report
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis. Although glucocorticoid therapy with or without immunosuppressants leads to remission in the majority of cases, most EGPA patients rem... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 19, 2022 Category: Allergy & Immunology Authors: Danxu Ma, Yuting Xue, Rong Shi, Yinan Yang, Huili Li, Xuhua Shi, Li Wang and Yun Wang Tags: Case report Source Type: research

Improvement of peripheral neuropathy in a patient with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis by additional mepolizumab
Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by abnormally high eosinophils and frequent peripheral neuropathy. Mepolizumab is an approved therapy for EGPA, but its effica... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - February 19, 2022 Category: Allergy & Immunology Authors: Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Kentaro Suzuki, Hiroya Ohara, Naohiko Iguchi, Takehito Kasamatsu, Kenji Uno, Nobuhiro Fujioka, Yukio Fujita and Shigeo Muro Tags: Case report Source Type: research